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Chemical Compound Review

PubChem8906     2-phenylaniline

Synonyms: CCRIS 753, SureCN25981, CHEMBL296021, NSC-7661, NCI-C50282, ...
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High impact information on o-Biphenylamine


Associations of o-Biphenylamine with other chemical compounds


Gene context of o-Biphenylamine

  • EGF did not induce Ca2+ mobilization, and 2-aminobiphenyl borate did not inhibit EGF-dependent COX-2 expression [1].

Analytical, diagnostic and therapeutic context of o-Biphenylamine

  • HPLC and TLC analytical techniques were used for separation and detection of [14C] 2-aminobiphenyl and its metabolites [7].


  1. Angiotensin II and epidermal growth factor induce cyclooxygenase-2 expression in intestinal epithelial cells through small GTPases using distinct signaling pathways. Slice, L.W., Chiu, T., Rozengurt, E. J. Biol. Chem. (2005) [Pubmed]
  2. 2- and 4-Aminobiphenyls induce oxidative DNA damage in human hepatoma (Hep G2) cells via different mechanisms. Wang, S.C., Chung, J.G., Chen, C.H., Chen, S.C. Mutat. Res. (2006) [Pubmed]
  3. Mouse-specific carcinogens: an assessment of hazard and significance for validation of short-term carcinogenicity bioassays in transgenic mice. Battershill, J.M., Fielder, R.J. Human & experimental toxicology. (1998) [Pubmed]
  4. The modulation by arylamines of the in vitro formation of superoxide anion radicals and hydrogen peroxide by rat liver microsomes. Manno, M., Ioannides, C., Gibson, G.G. Toxicol. Lett. (1985) [Pubmed]
  5. The appearance of mutagens in urine of rats after the administration of benzidine and some other aromatic amines. Bos, R.P., Brouns, R.M., van Doorn, R., Theuws, J.L., Henderson, P.T. Toxicology (1980) [Pubmed]
  6. Carcinogenesis bioassay in rats and mice fed diets containing 2-biphenylamine hydrochloride. Abdo, K.M., Murthy, A.S., Haseman, J.K., Dieter, M.P., Hildebrandt, P., Huff, J.E. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1982) [Pubmed]
  7. Metabolism of [14C]2-aminobiphenyl in vivo by different species. Kajbaf, M., Gorrod, J.W. European journal of drug metabolism and pharmacokinetics. (1987) [Pubmed]
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