Gene Review:
Ptgs2 - prostaglandin-endoperoxide synthase 2
Rattus norvegicus
Synonyms:
COX-2, Cox-2, Cox2, Cyclooxygenase-2, PGH synthase 2, ...
Kaiming Xu,
Chad M. Kitchen,
Hui-Kuo G. Shu,
Thomas J. Murphy,
Goppelt-Struebe,
Carrizo,
Gutkind,
Rappold,
Bosetti,
Ermert,
Daschner,
Lynd-Balta,
Neufeld,
Jin,
Oliveros,
Allen,
Merkle,
Weerasinghe,
O'Banion,
Guo,
Duncker,
Townsend,
Zhang,
Ermert,
Padowski,
Joseph,
Seltzer,
Cheng,
Grimminger,
Rosenberger,
Vallés,
Manucha,
Rapoport,
Seeger,
Hellmich,
- Selective inhibition of cyclooxygenase (COX)-2 reverses inflammation and expression of COX-2 and interleukin 6 in rat adjuvant arthritis. Anderson, G.D., Hauser, S.D., McGarity, K.L., Bremer, M.E., Isakson, P.C., Gregory, S.A. J. Clin. Invest. (1996)
- Selective inhibition of cyclooxygenase 2 spares renal function and prostaglandin synthesis in cirrhotic rats with ascites. Bosch-Marcè, M., Clària, J., Titos, E., Masferrer, J.L., Altuna, R., Poo, J.L., Jiménez, W., Arroyo, V., Rivera, F., Rodés, J. Gastroenterology (1999)
- Duodenal reflux induces cyclooxygenase-2 in the esophageal mucosa of rats: evidence for involvement of bile acids. Zhang, F., Altorki, N.K., Wu, Y.C., Soslow, R.A., Subbaramaiah, K., Dannenberg, A.J. Gastroenterology (2001)
- Enhanced cyclooxygenase-2 gene expression in alcoholic liver disease in the rat. Nanji, A.A., Miao, L., Thomas, P., Rahemtulla, A., Khwaja, S., Zhao, S., Peters, D., Tahan, S.R., Dannenberg, A.J. Gastroenterology (1997)
- Induction of cyclooxygenase-2 and peroxisome proliferator-activated receptor-gamma during nitric oxide-induced apoptotic PC12 cell death. Lim, S.Y., Jang, J.H., Surh, Y.J. Ann. N. Y. Acad. Sci. (2003)
- Intrathecal administration of a cylcooxygenase-1, but not a cyclooxygenase-2 inhibitor, reverses the effects of laparotomy on exploratory activity in rats. Martin, T.J., Buechler, N.L., Eisenach, J.C. Anesth. Analg. (2006)
- Valproic acid down-regulates the conversion of arachidonic acid to eicosanoids via cyclooxygenase-1 and -2 in rat brain. Bosetti, F., Weerasinghe, G.R., Rosenberger, T.A., Rapoport, S.I. J. Neurochem. (2003)
- Enhancement of slow-wave sleep by tumor necrosis factor-alpha is mediated by cyclooxygenase-2 in rats. Terao, A., Matsumura, H., Yoneda, H., Saito, M. Neuroreport (1998)
- COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex. Kaufmann, W.E., Worley, P.F., Pegg, J., Bremer, M., Isakson, P. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Tsujii, M., DuBois, R.N. Cell (1995)
- Inducible cyclooxygenase may have anti-inflammatory properties. Gilroy, D.W., Colville-Nash, P.R., Willis, D., Chivers, J., Paul-Clark, M.J., Willoughby, D.A. Nat. Med. (1999)
- Inhibition of cyclooxygenase-2 potentiates retrograde endocannabinoid effects in hippocampus. Kim, J., Alger, B.E. Nat. Neurosci. (2004)
- Rat pulmonary cyclooxygenase-2 expression in response to endotoxin challenge: differential regulation in the various types of cells in the lung. Ermert, L., Ermert, M., Merkle, M., Goppelt-Struebe, M., Duncker, H.R., Grimminger, F., Seeger, W. Am. J. Pathol. (2000)
- Losartan modulation on NOS isoforms and COX-2 expression in early renal fibrogenesis in unilateral obstruction. Manucha, W., Oliveros, L., Carrizo, L., Seltzer, A., Vallés, P. Kidney Int. (2004)
- Effect of flosulide, a selective cyclooxygenase 2 inhibitor, on passive heymann nephritis in the rat. Blume, C., Heise, G., Mühlfeld, A., Bach, D., Schrör, K., Gerhardz, C.D., Grabensee, B., Heering, P. Kidney Int. (1999)
- Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastro-intestinal ulcer models in rats. Schmassmann, A., Peskar, B.M., Stettler, C., Netzer, P., Stroff, T., Flogerzi, B., Halter, F. Br. J. Pharmacol. (1998)
- Enhanced cyclooxygenase-2 expression in olfactory-limbic forebrain following kainate-induced seizures. Joseph, S.A., Lynd-Balta, E., O'Banion, M.K., Rappold, P.M., Daschner, J., Allen, A., Padowski, J. Neuroscience (2006)
- Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction. Harris, R.C., McKanna, J.A., Akai, Y., Jacobson, H.R., Dubois, R.N., Breyer, M.D. J. Clin. Invest. (1994)
- Immunohistochemical and functional correlations of renal cyclooxygenase-2 in experimental diabetes. Komers, R., Lindsley, J.N., Oyama, T.T., Schutzer, W.E., Reed, J.F., Mader, S.L., Anderson, S. J. Clin. Invest. (2001)
- Induction of cyclooxygenase 1 and 2 in the rat stomach during endotoxemia: role in resistance to damage. Ferraz, J.G., Sharkey, K.A., Reuter, B.K., Asfaha, S., Tigley, A.W., Brown, M.L., McKnight, W., Wallace, J.L. Gastroenterology (1997)
- Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis. Kawamori, T., Rao, C.V., Seibert, K., Reddy, B.S. Cancer Res. (1998)
- Dietary fat and colon cancer: modulation of cyclooxygenase-2 by types and amount of dietary fat during the postinitiation stage of colon carcinogenesis. Singh, J., Hamid, R., Reddy, B.S. Cancer Res. (1997)
- Posttranscriptional regulation of cyclooxygenase-2 in rat intestinal epithelial cells. Zhang, Z., Sheng, H., Shao, J., Beauchamp, R.D., DuBois, R.N. Neoplasia (2000)
- Effect of endotoxin treatment on the expression of cyclooxygenase-2 and prostaglandin synthases in spinal cord, dorsal root ganglia, and skin of rats. Schuligoi, R., Ulcar, R., Peskar, B.A., Amann, R. Neuroscience (2003)
- In-vitro and in-vivo anti-inflammatory effect of oxyresveratrol from Morus alba L. Chung, K.O., Kim, B.Y., Lee, M.H., Kim, Y.R., Chung, H.Y., Park, J.H., Moon, J.O. J. Pharm. Pharmacol. (2003)
- Design and synthesis of (Z)-1,2-diphenyl-1-(4-methanesulfonamidophenyl)alk-1-enes and (Z)-1-(4-azidophenyl)-1,2-diphenylalk-1-enes: novel inhibitors of cyclooxygenase-2 (COX-2) with anti-inflammatory and analgesic activity. Uddin, M.J., Praveen Rao, P.N., Knaus, E.E. Bioorg. Med. Chem. (2005)
- Endothelin stimulates prostaglandin endoperoxide synthase-2 mRNA expression and protein synthesis through a tyrosine kinase-signaling pathway in rat mesangial cells. Kester, M., Coroneos, E., Thomas, P.J., Dunn, M.J. J. Biol. Chem. (1994)
- Gastrin stimulates cyclooxygenase-2 expression in intestinal epithelial cells through multiple signaling pathways. Evidence for involvement of ERK5 kinase and transactivation of the epidermal growth factor receptor. Guo, Y.S., Cheng, J.Z., Jin, G.F., Gutkind, J.S., Hellmich, M.R., Townsend, C.M. J. Biol. Chem. (2002)
- Interleukin-13 enhances cyclooxygenase-2 expression in activated rat brain microglia: implications for death of activated microglia. Yang, M.S., Ji, K.A., Jeon, S.B., Jin, B.K., Kim, S.U., Jou, I., Joe, E. J. Immunol. (2006)
- Activation of the epidermal growth factor receptor in optic nerve astrocytes leads to early and transient induction of cyclooxygenase-2. Zhang, X., Neufeld, A.H. Invest. Ophthalmol. Vis. Sci. (2005)
- Up-regulation of cyclooxygenase-2 by inhibition of cyclooxygenase-1: a key to nonsteroidal anti-inflammatory drug-induced intestinal damage. Tanaka, A., Hase, S., Miyazawa, T., Takeuchi, K. J. Pharmacol. Exp. Ther. (2002)
- Platelet-derived growth factor-induced stabilization of cyclooxygenase 2 mRNA in rat smooth muscle cells requires the c-Src family of protein-tyrosine kinases. Xu, K., Kitchen, C.M., Shu, H.K., Murphy, T.J. J. Biol. Chem. (2007)
- Elevated levels of cyclooxygenase-2 in antigen-stimulated mast cells is associated with minimal activation of p38 mitogen-activated protein kinase. Hundley, T.R., Prasad, A.R., Beaven, M.A. J. Immunol. (2001)
- Cytosolic phospholipase A2 is required for cytokine-induced expression of type IIA secretory phospholipase A2 that mediates optimal cyclooxygenase-2-dependent delayed prostaglandin E2 generation in rat 3Y1 fibroblasts. Kuwata, H., Nakatani, Y., Murakami, M., Kudo, I. J. Biol. Chem. (1998)
- Regulation of the expression of cyclooxygenase-2 by nitric oxide in rat peritoneal macrophages. Habib, A., Bernard, C., Lebret, M., Creminon, C., Esposito, B., Tedgui, A., Maclouf, J. J. Immunol. (1997)
- Cyclooxygenase-2-mediated DNA damage. Lee, S.H., Williams, M.V., Dubois, R.N., Blair, I.A. J. Biol. Chem. (2005)
- Regulation of MDR-1 (P-glycoprotein) by cyclooxygenase-2. Patel, V.A., Dunn, M.J., Sorokin, A. J. Biol. Chem. (2002)