Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AG-D-42903 trimethyl-[(5-methyl-2...

Synonyms: NSC-34095, AC1Q1TMK, NSC34095, LS-18664, CTK8C6902, ...

This record was replaced with 4141.

Yousif, F.B. et al., Fusek, J. et al., Newberry, N.R. et al.

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Disease relevance of NCGC00024668-01

Methylfurmethide failed to hyperpolarize the ganglion at concentrations which evoked maximal depolarizations [1].

High impact information on NCGC00024668-01

Comparison of pharmacologic data for inhibition of K+- and MF-induced responses by a common series of Ca2+ channel antagonists in bladder and ileum revealed excellent correlations [2].
Regardless of stimulant, K+ or methylfurmethide (MF), or component of response, the same rank order of antagonist activities is expressed, suggestive of a single structure-activity relationship and the existence of a single category of binding site which may, however, exist in several affinity states [2].
This effect of methylfurmetide on heart atria was significantly decreased in the presence of EDMM [3].

Associations of NCGC00024668-01 with other chemical compounds

1. The effects of acetylcholine and methylfurmetide on isolated guinea-pigs heart atria in the presence or absence of O-ethyl-S-(2-dimethylaminoethyl)-methylphosphonothioate (EDMM) were investigated [3].

References

Pharmacological differences between two muscarinic responses of the rat superior cervical ganglion in vitro. Newberry, N.R., Priestley, T. Br. J. Pharmacol. (1987) [Pubmed]
Ca2+ channel antagonist actions in bladder smooth muscle: comparative pharmacologic and [3H]nitrendipine binding studies. Yousif, F.B., Bolger, G.T., Ruzycky, A., Triggle, D.J. Can. J. Physiol. Pharmacol. (1985) [Pubmed]
Actions of O-ethyl-S-(2-dimethylaminoethyl)-methylphosphonothioate and some pyridine aldoximes on isolated guinea-pigs heart atria. Fusek, J., Patocka, J., Bajgar, J. Acta Biol. Med. Ger. (1978) [Pubmed]

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