Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

TPGS [2,5,7,8-tetramethyl-2- (4,8,12...

Synonyms: Tocofersolan, Tocofersolano, Tocophersolan, Tocofersolanum, Liqui-E, ...

Yu, L. et al., Rümelin, A. et al., Mu, L. et al., Dintaman, J.M. et al.

Yu, Bridgers, Polli, Vickers, Long, Roy, Winnike, Coffin, Rümelin, Humbert, Fauth, Mu, Seow,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Tocofersolan

Vitamin E-TPGS increases absorption flux of an HIV protease inhibitor by enhancing its solubility and permeability [1].

High impact information on Tocofersolan

Inhibition of P-glycoprotein by D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) [2].
Overall, vitamin E-TPGS enhanced the absorption flux of amprenavir by increasing its solubility and permeability [1].
Directional transport through Caco-2 cell monolayers was determined in the presence and absence of vitamin E-TPGS and P-glycoprotein inhibitors [1].
Paclitaxel loaded polymeric nanoparticles with TPGS as surfactant stabiliser were fabricated and characterised in terms of their drug incorporation capability and release kinetics [3].
In order to study the clinical effects of the antioxidant alpha-tocopherol (tocofersolan, CAS 30999-06-5) a simple, robust, sensitive and reliable high performance liquid chromatography (HPLC) method using fluorescence detection for the daily measurement of alpha-tocopherol concentration in plasma is described [4].

References

Vitamin E-TPGS increases absorption flux of an HIV protease inhibitor by enhancing its solubility and permeability. Yu, L., Bridgers, A., Polli, J., Vickers, A., Long, S., Roy, A., Winnike, R., Coffin, M. Pharm. Res. (1999) [Pubmed]
Inhibition of P-glycoprotein by D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS). Dintaman, J.M., Silverman, J.A. Pharm. Res. (1999) [Pubmed]
Application of TPGS in polymeric nanoparticulate drug delivery system. Mu, L., Seow, P.H. Colloids and surfaces. B, Biointerfaces. (2006) [Pubmed]
Determination of alpha-tocopherol in plasma by high performance liquid chromatography with fluorescence detection and stability of alpha-tocopherol under different conditions. Rümelin, A., Humbert, T., Fauth, U. Arzneimittel-Forschung. (2004) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share