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Chemical Compound Review

Sinomedol     9-[2-[4-(4- fluorophenyl)carbonyl-1...

Synonyms: Metrenperona, Metrenperone, Metrenperonum, CHEMBL2104852, SureCN2109868, ...
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Disease relevance of Metrenperone

  • Economic, clinical and functional consequences of a treatment using metrenperone during an outbreak of shipping fever in cattle [1].
  • The effects of saline (control, group C) and metrenperone (treated, group M) on systemic and pulmonary hemodynamics were determined in conscious 7- to 15-day-old calves after they were intratracheally inoculated with Pasteurella haemolytica [2].
  • A specific 5-HT2 antagonist (metrenperone, 0.05 mg/kg of body weight) was administered IM 30 minutes before the cattle were given a 5-minute IV 5-HT infusion [3].

High impact information on Metrenperone


  1. Economic, clinical and functional consequences of a treatment using metrenperone during an outbreak of shipping fever in cattle. Genicot, B., Mouligneau, F., Rollin, F., Lindsey, J.K., Close, R., Lekeux, P. Vet. Rec. (1993) [Pubmed]
  2. Hemodynamic responses to Pasteurella haemolytica inoculation in calves given type 2 serotonergic antagonist. Desmecht, D., Linden, A., Amory, H., Lekeux, P. Can. J. Physiol. Pharmacol. (1996) [Pubmed]
  3. Pulmonary response to intravenous administration of 5-hydroxytryptamine after type-2 receptor blockade in healthy calves. Linden, A.S., Desmecht, D.J., Amory, H., Rollin, F.A., Michaux, C.L., Lekeux, P. Am. J. Vet. Res. (1993) [Pubmed]
  4. Effect of 5-hydroxytryptamine type-2 receptor blockade on pulmonary function in calves with experimentally induced Pasteurella haemolytica pneumonia. Hare, J.E., Tesarowski, D.B., Dawe, G.E., Vlaminck, K., Shewen, P.E., Viel, L. Am. J. Vet. Res. (1996) [Pubmed]
  5. Comparison of three metrenperone dosage regimens inhibiting the 5-hydroxytryptamine-induced pulmonary dysfunction in cattle. Linden, A.S., Desmecht, D.J., Amory, H., Rollin, F.A., Lekeux, P.M. Res. Vet. Sci. (1993) [Pubmed]
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