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MeSH Review

Pasteurellosis, Pneumonic

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Disease relevance of Pasteurellosis, Pneumonic


High impact information on Pasteurellosis, Pneumonic

  • We have determined the 1.35- and 1.45-A structures, respectively, of closed and open iron-loaded forms of Mannheimia haemolytica ferric ion-binding protein A. M. haemolytica is the causative agent in the economically important and fatal disease of cattle termed shipping fever [4].
  • Leukotoxin produced by Mannheimia (Pasteurella) haemolytica is an important virulence factor in shipping fever pneumonia in feedlot cattle and is a critical protective antigen [5].
  • To determine the density of mast cells (MCs) and the extent of substance P (SP) immunoreactivity during initiation and progression of pneumonic pasteurellosis (PP), 18 lambs were inoculated intrabronchially with Mannheimia (Pasteurella) haemolytica or saline, and lung tissue was collected at 1, 15 and 45 days post-inoculation (n=3, each group) [6].
  • CONCLUSIONS AND CLINICAL RELEVANCE: When used to treat pneumonic pasteurellosis in calves, danofloxacin and enrofloxacin can be expected to deliver concentration-dependent bactericidal activity against M. haemolytica, the bacteria most commonly associated with bovine respiratory tract disease [7].
  • Neutrophil-mediated endothelial injury and neutrophil degranulation were, at least in part, mediated by IL8, whereas PAF promoted superoxide release by neutrophils in this in vitro system designed to mimic the in vivo events that occur during the early stages of bovine pneumonic pasteurellosis [8].

Chemical compound and disease context of Pasteurellosis, Pneumonic


Biological context of Pasteurellosis, Pneumonic


Anatomical context of Pasteurellosis, Pneumonic


Gene context of Pasteurellosis, Pneumonic


  1. Characterization of immunodominant and potentially protective epitopes of Mannheimia haemolytica serotype 1 outer membrane lipoprotein PlpE. Ayalew, S., Confer, A.W., Blackwood, E.R. Infect. Immun. (2004) [Pubmed]
  2. Serum antibodies to Pasteurella haemolytica lipopolysaccharide: relationship to experimental bovine pneumonic pasteurellosis. Confer, A.W., Panciera, R.J., Mosier, D.A. Am. J. Vet. Res. (1986) [Pubmed]
  3. Field trial of theophylline in cattle with respiratory tract disease. McKenna, D.J., Koritz, G.D., Neff-Davis, C.A., Langston, V.C., Berger, L.L. J. Am. Vet. Med. Assoc. (1989) [Pubmed]
  4. Structural basis for iron binding and release by a novel class of periplasmic iron-binding proteins found in gram-negative pathogens. Shouldice, S.R., Skene, R.J., Dougan, D.R., Snell, G., McRee, D.E., Schryvers, A.B., Tari, L.W. J. Bacteriol. (2004) [Pubmed]
  5. Bordetella bronchiseptica fimbrial protein-enhanced immunogenicity of a Mannheimia haemolytica leukotoxin fragment. Rajeev, S., Kania, S.A., Nair, R.V., McPherson, J.T., Moore, R.N., Bemis, D.A. Vaccine (2001) [Pubmed]
  6. Mast cell density and substance P-like immunoreactivity during the initiation and progression of lung lesions in ovine Mannheimia (Pasteurella) haemolytica pneumonia. Ramírez-Romero, R., Brogden, K.A., Gallup, J.M., Sonea, I.M., Ackermann, M.R. Microb. Pathog. (2001) [Pubmed]
  7. Comparison of pharmacokinetics of danofloxacin and enrofloxacin in calves challenged with Mannheimia haemolytica. TerHune, T.N., Skogerboe, T.L., Shostrom, V.K., Weigel, D.J. Am. J. Vet. Res. (2005) [Pubmed]
  8. In vitro evaluation of the role of platelet-activating factor and interleukin-8 in Mannheimia haemolytica-induced bovine pulmonary endothelial cell injury. McClenahan, D.J., Evanson, O.A., Weiss, D.J. Am. J. Vet. Res. (2002) [Pubmed]
  9. Effect of enrofloxacin therapy on shipping fever pneumonia in feedlot cattle. Lekeux, P., Art, T. Vet. Rec. (1988) [Pubmed]
  10. Use of long-acting oxytetracycline against pasteurellosis in lambs. Appleyard, W.T., Gilmour, N.J. Vet. Rec. (1990) [Pubmed]
  11. Economic, clinical and functional consequences of a treatment using metrenperone during an outbreak of shipping fever in cattle. Genicot, B., Mouligneau, F., Rollin, F., Lindsey, J.K., Close, R., Lekeux, P. Vet. Rec. (1993) [Pubmed]
  12. Serum and tissue concentrations of erythromycin in calves with induced pneumonic pasteurellosis. Burrows, G.E., Gentry, M., Ewing, P. Am. J. Vet. Res. (1989) [Pubmed]
  13. Hemodynamic effects of acute pneumonia experimentally induced in newborn calves inoculated with Pasteurella haemolytica. Alnoor, S.A., Slocombe, R.F., Derksen, F.J., Robinson, N.E. Am. J. Vet. Res. (1986) [Pubmed]
  14. Expression of the neutrophil chemoattractant interleukin-8 in the lesions of bovine pneumonic pasteurellosis. Caswell, J.L., Middleton, D.M., Sorden, S.D., Gordon, J.R. Vet. Pathol. (1998) [Pubmed]
  15. Pulmonary expression of tumor necrosis factor alpha, interleukin-1 beta, and interleukin-8 in the acute phase of bovine pneumonic pasteurellosis. Malazdrewich, C., Ames, T.R., Abrahamsen, M.S., Maheswaran, S.K. Vet. Pathol. (2001) [Pubmed]
  16. Absence of circulating TNF alpha in experimental bovine pneumonic pasteurellosis. Espinasse, J., Peel, J.E., Voirol, M.J., Schelcher, F., Valarcher, J.F. Vet. Rec. (1993) [Pubmed]
  17. Role of tissue factor in intra-alveolar fibrin deposition and coagulopathy associated with pneumonic pasteurellosis in cattle. Rashid, J., Weiss, D.J., Bach, R., Murtaugh, M. Am. J. Vet. Res. (1997) [Pubmed]
  18. Increased tumor necrosis factor-alpha and interleukin-1 beta expression in the lungs of calves with experimental pneumonic pasteurellosis. Yoo, H.S., Maheswaran, S.K., Srinand, S., Ames, T.R., Suresh, M. Vet. Immunol. Immunopathol. (1995) [Pubmed]
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