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Chemical Compound Review

Amicarbalida     1,3-bis(3- carbamimidoylphenyl)urea

Synonyms: Amicarbalide, Amicarbalidum, CHEMBL177281, AG-J-63431, SureCN1818799, ...
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Disease relevance of NSC65378

  • Babesiosis in cattle is effectively treated by a large number of babesiacidal compounds, but in practice, diminazene aceturate (3 to 5 mg/kg, IM), amicarbalide (5 to 10 mg/kg, IM), and imidocarb (1 to 3 mg/kg, IM) are most often used [1].
  • When administered subcutaneously in 2 equal daily doses at a total dosage rate of 20 mg/kg, amicarbalide was found to be an effective agent for controlling acute infections of Anaplasma marginale and A. centrale in intact and splenectomized cattle [2].
  • The relapse interval, however, was shorter and more relapses occurred after treatment with amicarbalide than either of the other 2 drugs [3].

High impact information on NSC65378


Analytical, diagnostic and therapeutic context of NSC65378

  • These forms are non-infective, indistinguishable by light microscopy from those present after treatment with amicarbalide, a babesicidal drug, and persist in splenectomized mice [6].


  1. Pharmacotherapeutics of drugs used in treatment of anaplasmosis and babesiosis. Kuttler, K.L. J. Am. Vet. Med. Assoc. (1980) [Pubmed]
  2. Amicarbalide: a therapeutic agent for anaplasmosis. De Vos, A.J., Barrowman, P.R., Coetzer, J.A., Kellerman, T.S. Onderstepoort J. Vet. Res. (1978) [Pubmed]
  3. A comparison of the efficacy of isometamidium, amicarbalide and diminazene against Babesia canis in dogs and the effect on subsequent immunity. Stewart, C.G. Journal of the South African Veterinary Association. (1983) [Pubmed]
  4. A field strain of Babesia bovis apparently resistant to amicarbalide isethionate. Yeruham, I., Pipano, E., Davidson, M. Tropical animal health and production. (1985) [Pubmed]
  5. Curative effects of the antipiroplasms amicarbalide and imidocarb on Trypanosoma brucei infection in mice. Nathan, H.C., Soto, K.V., Moreira, R., Chunosoff, L., Hutner, S.H., Bacchi, C.J. J. Protozool. (1979) [Pubmed]
  6. Intra-erythrocytic death of the parasite in mice recovering from infection with Babesia microti. Clark, I.A., Richmond, J.E., Wills, E.J., Allison, A.C. Parasitology (1977) [Pubmed]
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