Disease relevance of NSC65378

• Babesiosis in cattle is effectively treated by a large number of babesiacidal compounds, but in practice, diminazene aceturate (3 to 5 mg/kg, IM), amicarbalide (5 to 10 mg/kg, IM), and imidocarb (1 to 3 mg/kg, IM) are most often used [1].
• When administered subcutaneously in 2 equal daily doses at a total dosage rate of 20 mg/kg, amicarbalide was found to be an effective agent for controlling acute infections of Anaplasma marginale and A. centrale in intact and splenectomized cattle [2].
• The relapse interval, however, was shorter and more relapses occurred after treatment with amicarbalide than either of the other 2 drugs [3].

High impact information on NSC65378

• A field strain of Babesia bovis apparently resistant to amicarbalide isethionate [4].
• The babesicides imidocarb and amicarbalide, which have structural similarities to the antitrypanosomatid diamidines, proved active against Trypanosoma brucei mouse infections: both cured infections when doses were administered daily for 3 days 24 h post-inoculation (curative dose imidocarb, 10 mg/kg; amicarbalide, 25 mg/kg) [5].

Analytical, diagnostic and therapeutic context of NSC65378

• These forms are non-infective, indistinguishable by light microscopy from those present after treatment with amicarbalide, a babesicidal drug, and persist in splenectomized mice [6].

References