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Chemical Compound Review:

Hpmpdap [(2S)-1-(2,6-diaminopurin-9- yl)-3-hydroxy...

Synonyms: CHEMBL261240, SureCN172847, KST-1A0735, AC1L2HPV, CTK8E0051, ...

Potmesil, P. et al., Dal Pozzo, F. et al., Lin, J.C. et al.

Potmesil, Krecmerová, Kmonícková, Holý, Zídek,

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Disease relevance of Hpmpdap

HPMPC, HPMPDAP, and HPMPO-DAPy were evaluated for their activities against orf virus replication in organotypic epithelial raft cultures from differentiated PLK cells [1].

High impact information on Hpmpdap

HPMPC, (S)-9-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6- diaminopurine (HPMPDAP), and (R)-9-[3-hydroxy-2-(phosphonomethoxy)propoxy]-2,4-diaminopyrimidine (HPMPO-DAPy) were three of the most active compounds that were subsequently tested in a virus yield assay with PLK and HEL cells by virus titration and DNA quantification [1].
The relative efficacies based on the in vitro therapeutic index was (S)-HPMPC (5,000) greater than PMEDAP (1,000) = (S)-HPMPA (1,000) greater than (S)-cHPMPA (136) greater than (S)-HPMPDAP (78) [2].
Both HPMPA and HPMPDAP augmented the interferon-gamma-triggered production of NO as well as expression of inducible nitric oxide synthase (iNOS) mRNA in macrophages [3].
Newly developed acyclic nucleoside phosphonates, derivatives of adenine and 2,6-diaminopurine bearing the 2-hydroxy-3-(phosphonomethoxy)propyl (HPMP) moiety at the N9-side chain (i.e., HPMPA and HPMPDAP, respectively) were screened for in vitro immunobiological activity, using mouse resident peritoneal macrophages and splenocytes [3].

References

Activities of acyclic nucleoside phosphonates against Orf virus in human and ovine cell monolayers and organotypic ovine raft cultures. Dal Pozzo, F., Andrei, G., Holy, A., Van Den Oord, J., Scagliarini, A., De Clercq, E., Snoeck, R. Antimicrob. Agents Chemother. (2005) [Pubmed]
Inhibitory effects of acyclic nucleoside phosphonate analogs, including (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, on Epstein-Barr virus replication. Lin, J.C., De Clercq, E., Pagano, J.S. Antimicrob. Agents Chemother. (1991) [Pubmed]
Nucleotide analogues with immunobiological properties: 9-[2-Hydroxy-3-(phosphonomethoxy)propyl]-adenine (HPMPA), -2,6-diaminopurine (HPMPDAP), and their N6-substituted derivatives. Potmesil, P., Krecmerová, M., Kmonícková, E., Holý, A., Zídek, Z. Eur. J. Pharmacol. (2006) [Pubmed]

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