Chemical Compound Review:
Diaminopurine 7H-purine-2,6-diamine
Synonyms:
PubChem9203, NSC-743, CCRIS 923, SureCN24052, SureCN24053, ...
- Amdoxovir versus placebo with enfuvirtide plus optimized background therapy for HIV-1-infected subjects failing current therapy (AACTG A5118). Gripshover, B.M., Ribaudo, H., Santana, J., Gerber, J.G., Campbell, T.B., Hogg, E., Jarocki, B., Hammer, S.M., Kuritzkes, D.R. Antivir. Ther. (Lond.) (2006)
- DNA containing the base analogue 2-aminoadenine: preparation, use as hybridization probes and cleavage by restriction endonucleases. Chollet, A., Kawashima, E. Nucleic Acids Res. (1988)
- Mechanism of action and in vitro activity of 1',3'-dioxolanylpurine nucleoside analogues against sensitive and drug-resistant human immunodeficiency virus type 1 variants. Gu, Z., Wainberg, M.A., Nguyen-Ba, N., L'Heureux, L., de Muys, J.M., Bowlin, T.L., Rando, R.F. Antimicrob. Agents Chemother. (1999)
- Synthesis and antiviral evaluation of carbocyclic analogues of ribofuranosides of 2-amino-6-substituted-purines and of 2-amino-6-substituted-8-azapurines. Shealy, Y.F., Clayton, J.D., Arnett, G., Shannon, W.M. J. Med. Chem. (1984)
- A facile, alternative synthesis of 4'-thioarabinonucleosides and their biological activities. Yoshimura, Y., Watanabe, M., Satoh, H., Ashida, N., Ijichi, K., Sakata, S., Machida, H., Matsuda, A. J. Med. Chem. (1997)
- Chromosome instability contributes to loss of heterozygosity in mice lacking p53. Shao, C., Deng, L., Henegariu, O., Liang, L., Stambrook, P.J., Tischfield, J.A. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Mitotic recombination produces the majority of recessive fibroblast variants in heterozygous mice. Shao, C., Deng, L., Henegariu, O., Liang, L., Raikwar, N., Sahota, A., Stambrook, P.J., Tischfield, J.A. Proc. Natl. Acad. Sci. U.S.A. (1999)
- In vitro anti-human immunodeficiency virus activities of Z- and E-methylenecyclopropane nucleoside analogues and their phosphoro-L-alaninate diesters. Uchida, H., Kodama, E.N., Yoshimura, K., Maeda, Y., Kosalaraksa, P., Maroun, V., Qiu, Y.L., Zemlicka, J., Mitsuya, H. Antimicrob. Agents Chemother. (1999)
- Intracellular metabolism of 2',3'-dideoxynucleosides in duck hepatocyte primary cultures. Kitos, T.E., Tyrrell, D.L. Biochem. Pharmacol. (1995)
- Investigations on the anti-HIV activity of 2',3'-dideoxyadenosine analogues with modifications in either the pentose or purine moiety. Potent and selective anti-HIV activity of 2,6-diaminopurine 2',3'-dideoxyriboside. Pauwels, R., Baba, M., Balzarini, J., Herdewijn, P., Desmyter, J., Robins, M.J., Zou, R.M., Madej, D., De Clercq, E. Biochem. Pharmacol. (1988)
- Anti-herpesvirus activity profile of 4'-thioarabinofuranosyl purine and uracil nucleosides and activity of 1-beta-D-2'-fluoro-4'-thioarabinofuranosyl guanine and 2,6-diaminopurine against clinical isolates of human cytomegalovirus. Machida, H., Ashida, N., Miura, S., Endo, M., Yamada, K., Kitano, K., Yoshimura, Y., Sakata, S., Ijichi, O., Eizuru, Y. Antiviral Res. (1998)
- Ribavirin and mycophenolic acid potentiate the activity of guanine- and diaminopurine-based nucleoside analogues against hepatitis B virus. Ying, C., De Clercq, E., Neyts, J. Antiviral Res. (2000)
- High frequency in vivo loss of heterozygosity is primarily a consequence of mitotic recombination. Gupta, P.K., Sahota, A., Boyadjiev, S.A., Bye, S., Shao, C., O'Neill, J.P., Hunter, T.C., Albertini, R.J., Stambrook, P.J., Tischfield, J.A. Cancer Res. (1997)
- 2,6-Diaminopurinedeoxyriboside as a prodrug of deoxyguanosine in L1210 cells. Weckbecker, G., Cory, J.G. Cancer Res. (1987)
- Thermodynamic studies of base pairing involving 2,6-diaminopurine. Cheong, C., Tinoco, I., Chollet, A. Nucleic Acids Res. (1988)
- Effects of base substitutions on the binding of a DNA-bending protein. Bailly, C., Waring, M.J., Travers, A.A. J. Mol. Biol. (1995)
- Acyclic analogues of 2'-deoxynucleosides related to 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine as potential antiviral agents. Martin, J.C., Jeffrey, G.A., McGee, D.P., Tippie, M.A., Smee, D.F., Matthews, T.R., Verheyden, J.P. J. Med. Chem. (1985)
- Selection of human cells having two different types of mutations in individual cells (genetic/artificial mutants). Application to the diagnosis of the heterozygous state for a type of adenine phosphoribosyltransferase deficiency. Kamatani, N., Kuroshima, S., Terai, C., Kawai, K., Mikanagi, K., Nishioka, K. Hum. Genet. (1987)
- Activity of the (R)-enantiomers of 9-(2-phosphonylmethoxypropyl)-adenine and 9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine against human immunodeficiency virus in different human cell systems. Balzarini, J., Aquaro, S., Perno, C.F., Witvrouw, M., Holý, A., De Clercq, E. Biochem. Biophys. Res. Commun. (1996)
- Nucleotide analogues with immunobiological properties: 9-[2-Hydroxy-3-(phosphonomethoxy)propyl]-adenine (HPMPA), -2,6-diaminopurine (HPMPDAP), and their N6-substituted derivatives. Potmesil, P., Krecmerová, M., Kmonícková, E., Holý, A., Zídek, Z. Eur. J. Pharmacol. (2006)
- Similarity of in vivo somatic mutations at an autosomal adenine phosphoribosyltransferase locus between T- and B-cells in human peripheral blood. Hakoda, M., Kamatani, N., Terai, C., Yamanaka, H., Taniguchi, A., Ueda, H., Kashiwazaki, S. Mutat. Res. (1996)
- Synthesis of cell-permeable peptide nucleic acids and characterization of their hybridization and uptake properties. Zhou, P., Dragulescu-Andrasi, A., Bhattacharya, B., O'Keefe, H., Vatta, P., Hyldig-Nielsen, J.J., Ly, D.H. Bioorg. Med. Chem. Lett. (2006)
- 5-Phosphoribosyl 1-pyrophosphate synthetase converts the acyclic nucleoside phosphonates 9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and 9-(2-phosphonylmethoxyethyl)adenine directly to their antivirally active diphosphate derivatives. Balzarini, J., De Clercq, E. J. Biol. Chem. (1991)
- Transcription of T7 DNA containing modified nucleotides by bacteriophage T7 specific RNA polymerase. Stahl, S.J., Chamberlin, M.J. J. Biol. Chem. (1978)
- Guanine modification during chemical DNA synthesis. Eadie, J.S., Davidson, D.S. Nucleic Acids Res. (1987)
- Enhanced high density oligonucleotide array-based sequence analysis using modified nucleoside triphosphates. Hacia, J.G., Woski, S.A., Fidanza, J., Edgemon, K., Hunt, N., McGall, G., Fodor, S.P., Collins, F.S. Nucleic Acids Res. (1998)
- Purine reutilization and synthesis de novo in long-term human lymphocyte cell lines deficient in adenine phosphoribosyltransferase activity. Spector, E.B., Hershfield, M.S., Seegmiller, J.E. Somatic Cell Genet. (1978)
- Substrate analogues for an RNA-editing adenosine deaminase: mechanistic investigation and inhibitor design. Véliz, E.A., Easterwood, L.M., Beal, P.A. J. Am. Chem. Soc. (2003)
- Evidence for three thymine DNA glycosylases in human cell extracts: substrate specificities of thymine DNA glycosylase activities. Lari, S.U., Xu, Y.Z., Day, R.S. Med. Sci. Monit. (2005)
- Crystal structure of calf spleen purine nucleoside phosphorylase in a complex with multisubstrate analogue inhibitor with 2,6-diaminopurine aglycone. Koellner, G., Stroh, A., Raszewski, G., Holý, A., Bzowska, A. Nucleosides Nucleotides Nucleic Acids (2003)
- Phosphonylmethoxyethyl purine derivatives, a new class of anti-human immunodeficiency virus agents. Pauwels, R., Balzarini, J., Schols, D., Baba, M., Desmyter, J., Rosenberg, I., Holy, A., De Clercq, E. Antimicrob. Agents Chemother. (1988)
- High affinity binding of MEF-2C correlates with DNA bending. Meierhans, D., Sieber, M., Allemann, R.K. Nucleic Acids Res. (1997)
- 2,6-diaminopurine in TNA: effect on duplex stabilities and on the efficiency of template-controlled ligations. Wu, X., Delgado, G., Krishnamurthy, R., Eschenmoser, A. Org. Lett. (2002)
- Heritable alterations at the adenine phosphoribosyltransferase (APRT) locus in human lymphoblastoid cell lines. Amundson, S.A., Fortunato, J.E., Liber, H.L. Mutat. Res. (1992)