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Chemical Compound Review:

COMDP phosphonocarbonylphosphonic acid

Synonyms: AC1L2HQY, AC1Q6RKF, AR-1L0744, 17255-30-0, Carbonyldiphosphonate, ...

Ríman, J. et al., Ríman, J., Ríman, J. et al., Peng, Z.Y. et al., Eriksson, B. et al.

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High impact information on Carbonyldiphosphonate

Tetrasodium carbonyldiphosphonate did not show a significant effect against replication of T. gondii cells, probably because, as a charged molecule, it could not cross the cell membrane to reach the intracellular parasite [1].
Anatomy of the primase-alpha DNA polymerase reaction accomplished by nucleoprotein complexes harboring an extrachromosomal DNA identical with avian myeloblastosis virus core-bound DNA: influencing by carbonyldiphosphonate, mimosine and butylphenyl deoxyguanosine-5'-triphosphate [2].
Moreover, analyzing this natural model replication system, we found that the carbonyldiphosphonate (COMDP), a selective inhibitor of the PCNA-insensitive delta DNA pol, was a strong activator of Pr-As and/or Pr-alpha DNA pol As of NP complexes of POMS component C [3].
These were performed in the absence and presence of N2-(p-butylphenyl) deoxyguanosine 5'-triphosphate (BuPdGTP), aphidicolin (Aph) and carbonyldiphosphonate (COMDP), inhibitors allowing differentiation between two DNA polymerases (pols) involved in a lagging DNA strand synthesis (LSS) [4].
Phosphonoformate, phosphonoacetate, and to a lesser extent alpha-hydroxyphosphonoacetate, carbonyldiphosphonate and alpha-nonylphosphonoacetate also inhibited the focus formation by CMV in cell-culture [5].

References

Some phosphonic acid analogs as inhibitors of pyrophosphate-dependent phosphofructokinase, a novel target in Toxoplasma gondii. Peng, Z.Y., Mansour, J.M., Araujo, F., Ju, J.Y., McKenna, C.E., Mansour, T.E. Biochem. Pharmacol. (1995) [Pubmed]
Anatomy of the primase-alpha DNA polymerase reaction accomplished by nucleoprotein complexes harboring an extrachromosomal DNA identical with avian myeloblastosis virus core-bound DNA: influencing by carbonyldiphosphonate, mimosine and butylphenyl deoxyguanosine-5'-triphosphate. Ríman, J. Acta Virol. (2001) [Pubmed]
Activities of a lagging DNA strand synthesis of nucleoprotein complexes harboring an extrachromosomal DNA closely related to avian myeloblastosis virus core-bound DNA. Ríman, J., Sulová, A. Acta Virol. (1997) [Pubmed]
Products of a lagging DNA strand synthesis of nucleoprotein complexes harboring an extrachromosomal DNA closely related to avian myeloblastosis virus core-bound DNA. Ríman, J., Sulová, A. Acta Virol. (1997) [Pubmed]
Pyrophosphate analogues as inhibitors of DNA polymerases of cytomegalovirus, herpes simplex virus and cellular origin. Eriksson, B., Oberg, B., Wahren, B. Biochim. Biophys. Acta (1982) [Pubmed]

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