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Chemical Compound Review:

D01829 (2R,3S,14R,15R,16R,18R,20R,22S ,24S,26S...

Synonyms:

Shih, H.D. et al., Hidaka, K. et al., Li, Z. et al., Twentyman, P.R.

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Disease relevance of D01829

Fungichromin: a substance from Streptomyces padanus with inhibitory effects on Rhizoctonia solani [1].

High impact information on D01829

An amphotericin B-resistant cell (AMBR-1), which was isolated from aneuploid Chinese hamster cells (V79), was found to show much higher resistance than the parent V79 cells to other polyene antibiotics, such as pentamycin and filipin [2].
The effect of bleomycin and pentamycin in combination on the survival of EMT6 mouse tumour cells in vitro and in vivo [3].
Ethyl (Z)-16-phenylhexadec-9-enoate (3), an analog of ethyl oleate (2), was synthesized and added to cultures of Streptomyces cellulosae ATCC 12625 which normally produce fungichromin (1) as the principal polyene antibiotic [4].

Analytical, diagnostic and therapeutic context of D01829

Bioassay studies showed that fungichromin had a strong antifungal activity against R. solani AG-4, and its minimum inhibitory concentration (over 90% inhibition) was found to be 72 microg/mL [1].

References

Fungichromin: a substance from Streptomyces padanus with inhibitory effects on Rhizoctonia solani. Shih, H.D., Liu, Y.C., Hsu, F.L., Mulabagal, V., Dodda, R., Huang, J.W. J. Agric. Food Chem. (2003) [Pubmed]
Differential control of synergistic effect with polyene macrolide antibiotics upon Chinese hamster cells in vitro. Hidaka, K., Matsui, K., Endo, H., Akiyama, S.I., Kuwano, M. Cancer Res. (1978) [Pubmed]
The effect of bleomycin and pentamycin in combination on the survival of EMT6 mouse tumour cells in vitro and in vivo. Twentyman, P.R. Br. J. Cancer (1976) [Pubmed]
Production of new polyene antibiotics by Streptomyces cellulosae after addition of ethyl (Z)-16-phenylhexadec-9-enoate. Li, Z., Rawlings, B.J., Harrison, P.H., Vederas, J.C. J. Antibiot. (1989) [Pubmed]

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