Disease relevance of Ethyl oleate

• Selective accumulation and tumoricidal effect of cisplatin suspended in viscous ethyl oleate on hepatic cancers in animals after intraarterial infusion [1].
• On days 9 and 10 of gestation, pregnant NMRI mice were given subcutaneous injections of ethyl oleate alone (0.1 ml) or zeranol or DES (150 micrograms/kg body weight) in ethyl oleate [2].

Psychiatry related information on Ethyl oleate

• Interaction of ethyl oleate with a signalling mechanism involving PKC may underlie the cognitive disturbances noted after alcohol consumption [3].
• By application of the method to hair samples of 21 fatalities with known heavy alcohol abuse 0.045-2.4ng/mg ethyl myristate, 0.35-13.5ng/mg ethyl palmitate, 0.25-7.7ng/mg ethyl oleate and 0.05-3.85ng/mg ethyl stearate were measured [4].

High impact information on Ethyl oleate

• 51Chromium EDTA clearance increased significantly during oleic acid and glycerol-1-mono-oleate perfusion, but did not increase during perfusion with ethyl oleate or saline [5].
• Control fetuses were administered ethyl oleate (EtOle) [6].
• This 52-kDa monomeric protein is present at 0.6-1.2 mg/g of pancreas, and it catalyzes the synthesis and hydrolysis of ethyl oleate at rates of 2400 nmol mg-1 h-1 and 30 nmol mg-1 h-1, respectively [7].
• CONCLUSIONS: Ethyl oleate concentration in meconium assayed by GC/MS/MS provides a highly sensitive and specific indicator of maternal alcohol use during pregnancy [8].
• Ethyl oleate was most strongly related to drinking in the second and third trimesters (Pearson r=.55 and.40, respectively) [8].

Chemical compound and disease context of Ethyl oleate

• Pregnant NMRI mice were injected subcutaneously with ethyl oleate (0.1 mL) alone (negative control) or with 150 micrograms/kg of body weight of zeranol or DES (positive control) on days 9 and 10 of gestation [9].

Biological context of Ethyl oleate

• Truncal vagotomy (TVX) and selective celiac-branch vagotomy (CVX) are equally effective in attenuating, but not eliminating, suppression of food intake by LA and EO [10].
• After mating, sows were allocated either to be treated with ethyl oleate (control group) or to receive progesterone (P4) therapy (progesterone group) as 2 mg of P4/kg(.75) i.m., every 12 h from 36 to 96 h after onset of standing estrus [11].

Anatomical context of Ethyl oleate

• Indeed, peripheral human leukocytes contain detectable fatty acid ethyl ester synthase activity: 1.2 X 10(6) leukocytes from 10 ml blood catalyze the synthesis of ethyl oleate at 1.4 nmol/4 hr [12].
• In vitro studies were conducted to investigate the binding of ethyl oleate (FAEE) to mitochondria and their capacity to hydrolyze these FAEE [13].
• Rat pancreatic lysosomes were incubated for 20 minutes at 20 degrees C with ethyl oleate (a representative fatty acid ethyl ester) [14].
• For infusion into the carotid artery in hamsters, neat ethyl oleate (EO, 4cP) or VEOs of various apparent viscosities (40, 80, 120 cP-VEOs) embolized the vascular system in the cheek pouch, although arrival time to the site where the embolization was observed and the embolization period differed depending on the type of oily drug carrier [15].

Associations of Ethyl oleate with other chemical compounds

• Hormone-sensitive lipase hydrolyzed emulsified ethyl oleate as efficiently as that of trioleoylglycerol, but in mixed ethyl oleate/trioleoyl glycerol particles the hydrolysis of ethyl oleate was slower, suggesting a decreased accessibility [16].
• Also, ethyl oleate was found to correlate with total systemic ethanol exposure for both guinea pigs and humans, correlation coefficients equalling 0.67 (P < 0.05) and 0.49 (P < 0.05), respectively [17].
• The optimized SMEDDS formulations containing Ethyl oleate (20%), Tween 80 (60%), and PEG 400 (20%) were tested for in vitro dissolution [18].

Gene context of Ethyl oleate

• In both the liver and pancreas, analysis of individual FAEE species demonstrated a selective increase in ethyl oleate [19].

Analytical, diagnostic and therapeutic context of Ethyl oleate

• In other experiments, mononuclear cells were incubated with 10, 25, and 50 microM ethyl oleate for 0.08 to 120 minutes, and then the concentration of cAMP was determined by a cAMP competitive enzyme immunoassay system [20].
• The requisite diaminodithiol (N2S2) ligand, 9,10-bis[N-(2'-methyl-2'-mercapto)propyl] aminooctadecanoic acid, was prepared in nine steps from ethyl oleate and characterized by fast atom bombardment mass spectrometry and elemental analysis of its nickell(II) complex [21].
• Lipids were extracted with acetone, and 14C-labeled ethyl oleate was isolated and quantified by thin layer chromatography (TLC) and scintillation spectrometry [22].
• The raisins were produced either by submersion for 3 min in an aqueous solution of 3% potassium carbonate and 1% ethyl oleate, and dried for 15 days under direct sunlight or were dried without chemical processing [23].
• Purification of injectable ethyl oleate containing high concentrations of peroxide [24].

References