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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

glutarate     pentanedioic acid

Synonyms: Glutarsaeure, Pentandioate, GLUTARIC ACID, PubChem18989, G3407_ALDRICH, ...
 
 
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Psychiatry related information on pentanedioic acid

  • METHODS: We tested whether acute exposure to the NAALADase inhibitor 2-[[hydroxy[2,3,4,5,6-pentafluorophenyl)methyl]phosphinyl]methyl] pentanedioic acid (GPI-5232), administered 30 min prior to a social interaction test, would inhibit aggressive behavior in SJL mice that had been individually housed long term [1].
 

High impact information on pentanedioic acid

  • RESULTS: hOAT3-mediated efflux of glutarate (GA), can be significantly trans-stimulated by a variety of ions with high cis-inhibitory potency, including GA (282%), alpha-ketoglutarate (476%), p-aminohippurate (179%), and, most notably, urate (167%) [2].
  • The solution properties and conformational features of 2-substituted propanoic acid (I) and 2-substituted pentanedioic acid (II) derivatives of chitosan were investigated over a wide range of pH by potentiometric, optical and chiroptical measurements, and by theoretical conformational analysis [3].

References

  1. Reduced isolation-induced aggressiveness in mice following NAALADase inhibition. Lumley, L.A., Robison, C.L., Slusher, B.S., Wozniak, K., Dawood, M., Meyerhoff, J.L. Psychopharmacology (Berl.) (2004) [Pubmed]
  2. Human organic anion transporter 3 (hOAT3) can operate as an exchanger and mediate secretory urate flux. Bakhiya, A., Bahn, A., Burckhardt, G., Wolff, N. Cell. Physiol. Biochem. (2003) [Pubmed]
  3. Branched-chain analogues of linear polysaccharides: a spectroscopic and conformational investigation of chitosan derivatives. Paradossi, G., Chiessi, E., Venanzi, M., Pispisa, B., Palleschi, A. Int. J. Biol. Macromol. (1992) [Pubmed]
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