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Chemical Compound Review

pentanedioate     pentanedioate

Synonyms: CHEBI:30921, AC1N9XSM, ZINC00388706, AKOS015833759, A802271, ...
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Disease relevance of pentanedioic acid


High impact information on pentanedioic acid


Chemical compound and disease context of pentanedioic acid


Biological context of pentanedioic acid


Anatomical context of pentanedioic acid


Associations of pentanedioic acid with other chemical compounds


Gene context of pentanedioic acid

  • [3H]E1S uptake via S2 OAT4 was significantly trans-stimulated by preloaded GA (P<0.001) and its [14C]GA efflux was significantly trans-stimulated by unlabeled E1S in the medium (P<0.05) [26].
  • The Na(+)/dicarboxylate cotransporters (NaDC1) from mouse (m) and rabbit (rb) differ in their ability to handle glutarate [27].
  • Crystal structures of branched-chain amino acid aminotransferase complexed with glutamate and glutarate: true reaction intermediate and double substrate recognition of the enzyme [28].
  • Initial binding of TGF-beta2 to difunctional succinimidyl glutarate (D-SG-PEG) or succinimidyl propionate polyethylene glycol (D-SE-PEG) linkers was completed after reacting for 8 or 10 min as monitored by reverse-phase high-performance liquid chromatography [29].
  • Barbiturate and 3,3'-tetramethylene glutarate potently inhibited AR-H, and quercitrin significantly decreased the activity of CR-K1, CR-K2, and AR-L [30].

Analytical, diagnostic and therapeutic context of pentanedioic acid


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  3. Activity in monomers of human cytomegalovirus protease. Holwerda, B. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  4. Fermentative degradation of glutarate via decarboxylation by newly isolated strictly anaerobic bacteria. Matthies, C., Schink, B. Arch. Microbiol. (1992) [Pubmed]
  5. Circulating half-life of PEGylated recombinant methioninase holoenzyme is highly dose dependent on cofactor pyridoxal-5'-phosphate. Yang, Z., Sun, X., Li, S., Tan, Y., Wang, X., Zhang, N., Yagi, S., Takakura, T., Kobayashi, Y., Takimoto, A., Yoshioka, T., Suginaka, A., Frenkel, E.P., Hoffman, R.M. Cancer Res. (2004) [Pubmed]
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  7. Mechanism of organic anion transport across the apical membrane of choroid plexus. Pritchard, J.B., Sweet, D.H., Miller, D.S., Walden, R. J. Biol. Chem. (1999) [Pubmed]
  8. Purification and characterization of 2-keto-3-deoxy-6-phosphogluconate aldolase from Azotobacter vinelandii: evidence that the enzyme is bifunctional towards 2-keto-4-hydroxy glutarate cleavage. Taha, T.S., Deits, T.L. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  9. Metabolism and toxicity of synthetic analogues of macrocyclic diester pyrrolizidine alkaloids. Mattocks, A.R., Driver, H.E., Barbour, R.H., Robins, D.J. Chem. Biol. Interact. (1986) [Pubmed]
  10. X-ray crystallographic study of pyridoxamine 5'-phosphate-type aspartate aminotransferases from Escherichia coli in three forms. Miyahara, I., Hirotsu, K., Hayashi, H., Kagamiyama, H. J. Biochem. (1994) [Pubmed]
  11. Genes and enzymes of lysine catabolism in Pseudomonas aeruginosa. Rahman, M., Clarke, P.H. J. Gen. Microbiol. (1980) [Pubmed]
  12. Resonance Raman studies on protocatechuate 3,4-dioxygenase-inhibitor complexes. Que, L., Epstein, R.M. Biochemistry (1981) [Pubmed]
  13. Tryptophan and glucose metabolism in rat liver cells. The effects of DL-6-chlorotryptophan, 4-chloro-3-hydroxyanthranilate and pyrazinamide. Cook, J.S., Pogson, C.I. Biochem. J. (1983) [Pubmed]
  14. alpha-Ketoglutarate transport in rat renal brush-border and basolateral membrane vesicles. Edwards, R.M., Stack, E., Trizna, W. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
  15. Mutation analysis of the GCDH gene in Italian and Portuguese patients with glutaric aciduria type I. Busquets, C., Soriano, M., de Almeida, I.T., Garavaglia, B., Rimoldi, M., Rivera, I., Uziel, G., Cabral, A., Coll, M.J., Ribes, A. Mol. Genet. Metab. (2000) [Pubmed]
  16. Basolateral transport of glutarate in proximal S2 segments of rabbit kidney: kinetics of the uptake process and effect of activators of protein kinase A and C. Röver, N., Krämer, C., Stärk, U., Gabriëls, G., Greven, J. Pflugers Arch. (1998) [Pubmed]
  17. Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes. Apiwattanakul, N., Sekine, T., Chairoungdua, A., Kanai, Y., Nakajima, N., Sophasan, S., Endou, H. Mol. Pharmacol. (1999) [Pubmed]
  18. Effects of organic acids on tubulin polymerization and associated guanosine 5'-triphosphate hydrolysis. Hamel, E., del Campo, A.A., Lowe, M.C., Waxman, P.G., Lin, C.M. Biochemistry (1982) [Pubmed]
  19. Glutaric aciduria type I: unusual biochemical presentation. Campistol, J., Ribes, A., Alvarez, L., Christensen, E., Millington, D.S. J. Pediatr. (1992) [Pubmed]
  20. Prenatal diagnosis and neonatal monitoring of a fetus with glutaric aciduria type II due to electron transfer flavoprotein (beta-subunit) deficiency. Yamaguchi, S., Shimizu, N., Orii, T., Fukao, T., Suzuki, Y., Maeda, K., Hashimoto, T., Previs, S.F., Rinaldo, P. Pediatr. Res. (1991) [Pubmed]
  21. NAD+ biosynthesis from tryptophan in the presence of nicotinic acid or vice versa by rat hepatocytes--effect of clofibrate-feeding. Shin, M., Nakakita, S., Hashimoto, C., Sano, K., Umezawa, C. International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition. (1998) [Pubmed]
  22. Negative co-operativity in glutamate dehydrogenase. Involvement of the 2-position in glutamate in the induction of conformational changes. Bell, E.T., LiMuti, C., Renz, C.L., Bell, J.E. Biochem. J. (1985) [Pubmed]
  23. Expression cloning and characterization of a renal organic anion transporter from winter flounder. Wolff, N.A., Werner, A., Burkhardt, S., Burckhardt, G. FEBS Lett. (1997) [Pubmed]
  24. Rat multispecific organic anion transporter 1 (rOAT1) transports zidovudine, acyclovir, and other antiviral nucleoside analogs. Wada, S., Tsuda, M., Sekine, T., Cha, S.H., Kimura, M., Kanai, Y., Endou, H. J. Pharmacol. Exp. Ther. (2000) [Pubmed]
  25. Functional characterization of the rat multispecific organic anion transporter OAT1 mediating basolateral uptake of anionic drugs in the kidney. Uwai, Y., Okuda, M., Takami, K., Hashimoto, Y., Inui, K. FEBS Lett. (1998) [Pubmed]
  26. Human organic anion transporter 4 is a renal apical organic anion/dicarboxylate exchanger in the proximal tubules. Ekaratanawong, S., Anzai, N., Jutabha, P., Miyazaki, H., Noshiro, R., Takeda, M., Kanai, Y., Sophasan, S., Endou, H. J. Pharmacol. Sci. (2004) [Pubmed]
  27. Transmembrane helices 3 and 4 are involved in substrate recognition by the Na+/dicarboxylate cotransporter, NaDC1. Oshiro, N., King, S.C., Pajor, A.M. Biochemistry (2006) [Pubmed]
  28. Crystal structures of branched-chain amino acid aminotransferase complexed with glutamate and glutarate: true reaction intermediate and double substrate recognition of the enzyme. Goto, M., Miyahara, I., Hayashi, H., Kagamiyama, H., Hirotsu, K. Biochemistry (2003) [Pubmed]
  29. Improved local delivery of TGF-beta2 by binding to injectable fibrillar collagen via difunctional polyethylene glycol. Bentz, H., Schroeder, J.A., Estridge, T.D. J. Biomed. Mater. Res. (1998) [Pubmed]
  30. Purification and properties of six aldo-keto reductases from rat adrenal gland. Inazu, N., Nagashima, Y., Satoh, T., Fujii, T. J. Biochem. (1994) [Pubmed]
  31. Studies into the thermodynamic origin of negative cooperativity in ion-pairing molecular recognition. Tobey, S.L., Anslyn, E.V. J. Am. Chem. Soc. (2003) [Pubmed]
  32. Matrix-assisted laser desorption/ionization mass spectrometry of discrete mass poly(butylene glutarate) oligomers. Williams, J.B., Chapman, T.M., Hercules, D.M. Anal. Chem. (2003) [Pubmed]
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