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Chemical Compound Review

AC1L9732     (2R,3S,4R,5R,6S)-5-amino-6- [(2R,4R,5R,6R)...

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Disease relevance of Chitosan


Psychiatry related information on Chitosan

  • By controlling the reaction time and by monitoring the reaction products with gel filtration high-performance liquid chromatography, chitosan oligosaccharides with a desired oligosaccharide content and composition were obtained [5].
  • It highlights the applications of chitosan as an antimicrobial agent against fungi, bacteria, and viruses and as an elicitor of plant defense mechanisms [6].
  • It is proposed that a combination therapy with liposomes and micelles of paclitaxel for systemic delivery along with implantation of chitosan film for local delivery, may serve not only to improve patient compliance by obliterating the need to administer Cremophor EL, but also increase patient survival [7].

High impact information on Chitosan


Chemical compound and disease context of Chitosan


Biological context of Chitosan


Anatomical context of Chitosan


Associations of Chitosan with other chemical compounds


Gene context of Chitosan


Analytical, diagnostic and therapeutic context of Chitosan


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  2. X-ray structure of an anti-fungal chitosanase from streptomyces N174. Marcotte, E.M., Monzingo, A.F., Ernst, S.R., Brzezinski, R., Robertus, J.D. Nat. Struct. Biol. (1996) [Pubmed]
  3. Intravenous delivery of anti-RhoA small interfering RNA loaded in nanoparticles of chitosan in mice: safety and efficacy in xenografted aggressive breast cancer. Pill??, J.Y., Li, H., Blot, E., Bertrand, J.R., Pritchard, L.L., Opolon, P., Maksimenko, A., Lu, H., Vannier, J.P., Soria, J., Malvy, C., Soria, C. Hum. Gene Ther. (2006) [Pubmed]
  4. Effect of chitosan on plasma lipoprotein concentrations in type 2 diabetic subjects with hypercholesterolemia. Tai, T.S., Sheu, W.H., Lee, W.J., Yao, H.T., Chiang, M.T. Diabetes Care (2000) [Pubmed]
  5. Purification and characterization of chitosanase from Bacillus sp. strain KCTC 0377BP and its application for the production of chitosan oligosaccharides. Choi, Y.J., Kim, E.J., Piao, Z., Yun, Y.C., Shin, Y.C. Appl. Environ. Microbiol. (2004) [Pubmed]
  6. Chitosan as antimicrobial agent: applications and mode of action. Rabea, E.I., Badawy, M.E., Stevens, C.V., Smagghe, G., Steurbaut, W. Biomacromolecules (2003) [Pubmed]
  7. In vivo pharmacokinetic and tissue distribution studies in mice of alternative formulations for local and systemic delivery of Paclitaxel: gel, film, prodrug, liposomes and micelles. Dhanikula, A.B., Singh, D.R., Panchagnula, R. Current drug delivery. (2005) [Pubmed]
  8. Oral gene delivery with chitosan--DNA nanoparticles generates immunologic protection in a murine model of peanut allergy. Roy, K., Mao, H.Q., Huang, S.K., Leong, K.W. Nat. Med. (1999) [Pubmed]
  9. Chs7p, a new protein involved in the control of protein export from the endoplasmic reticulum that is specifically engaged in the regulation of chitin synthesis in Saccharomyces cerevisiae. Trilla, J.A., Durán, A., Roncero, C. J. Cell Biol. (1999) [Pubmed]
  10. The function of chitin synthases 2 and 3 in the Saccharomyces cerevisiae cell cycle. Shaw, J.A., Mol, P.C., Bowers, B., Silverman, S.J., Valdivieso, M.H., Durán, A., Cabib, E. J. Cell Biol. (1991) [Pubmed]
  11. Suramin inhibits initiation of defense signaling by systemin, chitosan, and a beta-glucan elicitor in suspension-cultured Lycopersicon peruvianum cells. Stratmann, J., Scheer, J., Ryan, C.A. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  12. Hydrogen peroxide is generated systemically in plant leaves by wounding and systemin via the octadecanoid pathway. Orozco-Cardenas, M., Ryan, C.A. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  13. Exo-{beta}-D-glucosaminidase from Amycolatopsis orientalis: catalytic residues, sugar recognition specificity, kinetics, and synergism. Fukamizo, T., Fleury, A., C??t??, N., Mitsutomi, M., Brzezinski, R. Glycobiology (2006) [Pubmed]
  14. Dietary chitosan inhibits hypercholesterolaemia and atherogenesis in the apolipoprotein E-deficient mouse model of atherosclerosis. Ormrod, D.J., Holmes, C.C., Miller, T.E. Atherosclerosis (1998) [Pubmed]
  15. Development of bacterial contamination during production of yeast extracts. Barrette, J., Champagne, C.P., Goulet, J. Appl. Environ. Microbiol. (1999) [Pubmed]
  16. Therapeutic angiogenesis induced by controlled release of fibroblast growth factor-2 from injectable chitosan/non-anticoagulant heparin hydrogel in a rat hindlimb ischemia model. Fujita, M., Ishihara, M., Shimizu, M., Obara, K., Nakamura, S., Kanatani, Y., Morimoto, Y., Takase, B., Matsui, T., Kikuchi, M., Maehara, T. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society (2007) [Pubmed]
  17. Glycol chitosan improves the efficacy of intranasally administrated replication defective human adenovirus type 5 expressing glycoprotein D of bovine herpesvirus 1. Gogev, S., de Fays, K., Versali, M.F., Gautier, S., Thiry, E. Vaccine (2004) [Pubmed]
  18. Crystal structure of chitosanase from Bacillus circulans MH-K1 at 1.6-A resolution and its substrate recognition mechanism. Saito, J., Kita, A., Higuchi, Y., Nagata, Y., Ando, A., Miki, K. J. Biol. Chem. (1999) [Pubmed]
  19. Nitric oxide modulates fracture healing. Diwan, A.D., Wang, M.X., Jang, D., Zhu, W., Murrell, G.A. J. Bone Miner. Res. (2000) [Pubmed]
  20. Chitin deacetylases: new, versatile tools in biotechnology. Tsigos, I., Martinou, A., Kafetzopoulos, D., Bouriotis, V. Trends Biotechnol. (2000) [Pubmed]
  21. Transgene expression in the brain stem effected by intramuscular injection of polyethylenimine/DNA complexes. Wang, S., Ma, N., Gao, S.J., Yu, H., Leong, K.W. Mol. Ther. (2001) [Pubmed]
  22. Comparative effects of chitosan and cholestyramine on lymphatic absorption of lipids in the rat. Vahouny, G.V., Satchithanandam, S., Cassidy, M.M., Lightfoot, F.B., Furda, I. Am. J. Clin. Nutr. (1983) [Pubmed]
  23. RNA Interference in Vitro and in Vivo Using a Novel Chitosan/siRNA Nanoparticle System. Howard, K.A., Rahbek, U.L., Liu, X., Damgaard, C.K., Glud, S.Z., Andersen, M.Ø., Hovgaard, M.B., Schmitz, A., Nyengaard, J.R., Besenbacher, F., Kjems, J. Mol. Ther. (2006) [Pubmed]
  24. Kinetics and mode of peptide delivery via the respiratory mucosa determine the outcome of activation versus TH2 immunity in allergic inflammation of the airways. Hall, G., Lund, L., Lamb, J.R., Jarman, E.R. J. Allergy Clin. Immunol. (2002) [Pubmed]
  25. Identification of neurite outgrowth promoting sites on the laminin alpha 3 chain G domain. Kato, K., Utani, A., Suzuki, N., Mochizuki, M., Yamada, M., Nishi, N., Matsuura, H., Shinkai, H., Nomizu, M. Biochemistry (2002) [Pubmed]
  26. Local and systemic activity of the polysaccharide chitosan at lymphoid tissues after oral administration. Porporatto, C., Bianco, I.D., Correa, S.G. J. Leukoc. Biol. (2005) [Pubmed]
  27. Myelin basic protein kinase activity in tomato leaves is induced systemically by wounding and increases in response to systemin and oligosaccharide elicitors. Stratmann, J.W., Ryan, C.A. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  28. Loss of cell wall alpha(1-3) glucan affects Cryptococcus neoformans from ultrastructure to virulence. Reese, A.J., Yoneda, A., Breger, J.A., Beauvais, A., Liu, H., Griffith, C.L., Bose, I., Kim, M.J., Skau, C., Yang, S., Sefko, J.A., Osumi, M., Latge, J.P., Mylonakis, E., Doering, T.L. Mol. Microbiol. (2007) [Pubmed]
  29. A novel use of chitosan as a hypocholesterolemic agent in rats. Sugano, M., Fujikawa, T., Hiratsuji, Y., Nakashima, K., Fukuda, N., Hasegawa, Y. Am. J. Clin. Nutr. (1980) [Pubmed]
  30. Oligogalacturonic acid and chitosan reduce stomatal aperture by inducing the evolution of reactive oxygen species from guard cells of tomato and Commelina communis. Lee, S., Choi, H., Suh, S., Doo, I.S., Oh, K.Y., Choi, E.J., Schroeder Taylor, A.T., Low, P.S., Lee, Y. Plant Physiol. (1999) [Pubmed]
  31. Convergence of calcium signaling pathways of pathogenic elicitors and abscisic acid in Arabidopsis guard cells. Klüsener, B., Young, J.J., Murata, Y., Allen, G.J., Mori, I.C., Hugouvieux, V., Schroeder, J.I. Plant Physiol. (2002) [Pubmed]
  32. Activation of stress-responsive mitogen-activated protein kinase pathways in hybrid poplar (Populus trichocarpa x Populus deltoides). Hamel, L.P., Miles, G.P., Samuel, M.A., Ellis, B.E., Séguin, A., Beaudoin, N. Tree Physiol. (2005) [Pubmed]
  33. Involvement of protein kinase C in chitosan glutamate-mediated tight junction disruption. Smith, J.M., Dornish, M., Wood, E.J. Biomaterials (2005) [Pubmed]
  34. Chitosan inhibits prostaglandin E2 formation and cyclooxygenase-2 induction in lipopolysaccharide-treated RAW 264.7 macrophages. Chou, T.C., Fu, E., Shen, E.C. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  35. Controlled release of fibroblast growth factors and heparin from photocrosslinked chitosan hydrogels and subsequent effect on in vivo vascularization. Ishihara, M., Obara, K., Ishizuka, T., Fujita, M., Sato, M., Masuoka, K., Saito, Y., Yura, H., Matsui, T., Hattori, H., Kikuchi, M., Kurita, A. Journal of biomedical materials research. Part A. (2003) [Pubmed]
  36. Injectable bone using chitosan-alginate gel/mesenchymal stem cells/BMP-2 composites. Park, D.J., Choi, B.H., Zhu, S.J., Huh, J.Y., Kim, B.Y., Lee, S.H. Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery. (2005) [Pubmed]
  37. Effect of molecular weight on the exponential growth and morphology of hyaluronan/chitosan multilayers: a surface plasmon resonance spectroscopy and atomic force microscopy investigation. Kujawa, P., Moraille, P., Sanchez, J., Badia, A., Winnik, F.M. J. Am. Chem. Soc. (2005) [Pubmed]
  38. The novel lectin-like protein CHB1 is encoded by a chitin-inducible Streptomyces olivaceoviridis gene and binds specifically to crystalline alpha-chitin of fungi and other organisms. Schnellmann, J., Zeltins, A., Blaak, H., Schrempf, H. Mol. Microbiol. (1994) [Pubmed]
  39. Crystallization of a chitosanase from Streptomyces N174. Marcotte, E., Hart, P.J., Boucher, I., Brzezinski, R., Robertus, J.D. J. Mol. Biol. (1993) [Pubmed]
  40. Chitin-based embolic materials in the renal artery of rabbits: pathologic evaluation of an absorbable particulate agent. Kwak, B.K., Shim, H.J., Han, S.M., Park, E.S. Radiology. (2005) [Pubmed]
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