Disease relevance of chlorphenesin

• Fixed drug eruption from chlorphenesin carbamate [1].
• Dermatitis from chlorphenesin in a facial cosmetic [2].
• Allergic contact sensitivity to chlorphenesin [3].

High impact information on chlorphenesin

• Chlorphenesin, a stimulator of cellular immunity, was found to inhibit tumorigenesis in initiation-promotion skin carcinogenesis when injected during promotion [4].
• Suppressive effects of chlorphenesin on lymphocyte function in mice and humans [5].
• These studies suggest that chlorphenesin may have a broad spectrum of suppressive effects both on T and B cells and that the predominant inhibition of proliferative responses in these cells may reduce the expansion of clones of immunocompetent cells in vivo [5].
• Chlorphenesin, at doses of 20-50 micrograms/ml, inhibited mitogenic responses of both mouse and human B and T cells [5].
• Two cases of facial dermatitis due to chlorphenesin in cosmetics [6].

References