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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

chlorphenesin     3-(4-chlorophenoxy)propane- 1,2-diol

Synonyms: Gecophen, Adermykon, Demykon, Gechophen, Mycil, ...
 
 
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Disease relevance of chlorphenesin

 

High impact information on chlorphenesin

  • Chlorphenesin, a stimulator of cellular immunity, was found to inhibit tumorigenesis in initiation-promotion skin carcinogenesis when injected during promotion [4].
  • Suppressive effects of chlorphenesin on lymphocyte function in mice and humans [5].
  • These studies suggest that chlorphenesin may have a broad spectrum of suppressive effects both on T and B cells and that the predominant inhibition of proliferative responses in these cells may reduce the expansion of clones of immunocompetent cells in vivo [5].
  • Chlorphenesin, at doses of 20-50 micrograms/ml, inhibited mitogenic responses of both mouse and human B and T cells [5].
  • Two cases of facial dermatitis due to chlorphenesin in cosmetics [6].

References

  1. Fixed drug eruption from chlorphenesin carbamate. Coskey, R.J. JAMA (1982) [Pubmed]
  2. Dermatitis from chlorphenesin in a facial cosmetic. Wakelin, S.H., White, I.R. Contact Derm. (1997) [Pubmed]
  3. Allergic contact sensitivity to chlorphenesin. Burns, D.A. Contact Derm. (1986) [Pubmed]
  4. Initiation-promotion skin carcinogenesis and immunological competence. Curtis, G.L., Stenbäck, F., Ryan, W.L. Proc. Soc. Exp. Biol. Med. (1975) [Pubmed]
  5. Suppressive effects of chlorphenesin on lymphocyte function in mice and humans. Stites, D.P., Brecher, G., Schmidt, L., Berger, F.M. Immunopharmacology (1979) [Pubmed]
  6. Two cases of facial dermatitis due to chlorphenesin in cosmetics. Brown, V.L., Orton, D.I. Contact Derm. (2005) [Pubmed]
 
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