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Chemical Compound Review:

SureCN75814 isochroman-1-one

Synonyms: AG-F-60476, ACMC-209wpy, CHEBI:23745, ANW-46676, AK-84484, ...

Yamamoto, H. et al., Grosse, Y. et al., Jiang, X. et al., Li, Y.H. et al., Creppy, E.E. et al., et al.

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Disease relevance of isochroman-1-one

Evaluation of antiproliferative activity reveals that the dihydroisocoumarin fragment is important for psymberin toxicity and the cyclic pederate fragment is important for pederin/mycalamide toxicity [1].

High impact information on isochroman-1-one

Derailment product in NADPH-dependent synthesis of a dihydroisocoumarin 6-hydroxymellein by elicitor-treated carrot cell extracts [2].
Some metabolites of ochratoxin A, including the chlorinated dihydroisocoumarin moiety of OTA (OT alpha), 4-[S]-hydroxy-OTA and 4-[R]-hydroxy-OTA were detected by HPLC in the mixture of cell homogenate after a 24 h incubation with 10 and 25 microM of OTA [3].
OT alpha, (0.5-1.0 mM), the dihydroisocoumarin moiety of OTA, does not inhibit phenylalanine hydroxylase activity under these conditions [4].
Effect of a suitable combination of 1-naphthaleneacetic acid (NAA) and cytokinin N-(2-chloro-4-pyridyl)-N'-phenylurea (4PU30) concentrations, regarding organ differentiation and dihydroisocoumarin production, was examined in Hydrangea macrophylla var. thunbergii callus cultures [5].

Analytical, diagnostic and therapeutic context of isochroman-1-one

A new dihydroisocoumarin, 6-methoxyhydrangenol (1) as well as eleven known compounds were isolated from a traditional Chinese medicine, the rhizomes of Notopterygium forbesii Boiss [6].

References

Synthesis of psymberin analogues: probing a functional correlation with the pederin/mycalamide family of natural products. Jiang, X., Williams, N., Brabander, J.K. Org. Lett. (2007) [Pubmed]
Derailment product in NADPH-dependent synthesis of a dihydroisocoumarin 6-hydroxymellein by elicitor-treated carrot cell extracts. Kurosaki, F., Kizawa, Y., Nishi, A. Eur. J. Biochem. (1989) [Pubmed]
Formation of ochratoxin A metabolites and DNA-adducts in monkey kidney cells. Grosse, Y., Baudrimont, I., Castegnaro, M., Betbeder, A.M., Creppy, E.E., Dirheimer, G., Pfohl-Leszkowicz, A. Chem. Biol. Interact. (1995) [Pubmed]
The myocotoxin ochratoxin A is a substrate for phenylalanine hydroxylase in isolated rat hepatocytes and in vivo. Creppy, E.E., Chakor, K., Fisher, M.J., Dirheimer, G. Arch. Toxicol. (1990) [Pubmed]
Effect of cytokinin 4PU30 on organ differentiation and dihydroisocoumarin production in amacha callus cultures. Yamamoto, H., Yamamoto, M., Yamamoto, K., Chatani, N., Yoshikawa, M. Biol. Pharm. Bull. (1998) [Pubmed]
A new dihydroisocoumarin from the rhizomes of Notopterygium forbesii. Li, Y.H., Luo, F., Peng, S.L., Liang, J., Ding, L.S. Nat. Prod. Res. (2006) [Pubmed]

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