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Chemical Compound Review

Floramon     2-naphthalen-1-ylethanoic acid

Synonyms: Hormofix, Nafusaku, Phyomone, Planofix, Primacol, ...
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Disease relevance of Agronaa


High impact information on Agronaa


Biological context of Agronaa

  • The plasmid profiles of the strains forming the majority of the population on the freshly slaughtered birds were rarely present in the strains isolated from the pluckers (except at the entry to the first plucker) and were present in only a small proportion of the strains isolated from carcasses after plucking [10].
  • Northern experiments revealed a developmental regulation of the calreticulin transcript with a maximum during the early stages of somatic embryogenesis and an auxin dependence during in-vitro cell culture. alpha-Naphthaleneacetic acid stimulated calreticulin expression whereas 2,4-dichlorophenoxyacetic acid reduced it [11].
  • The shoot and corm organogenesis occurred from the compact calli when they were transferred to a medium containing 0.54 microM NAA and 4.44 microM 6-BA [12].

Anatomical context of Agronaa

  • In the first test of the hypothesis that NAA is an immediate precursor in NAAG biosynthesis, [3H]-NAA was incorporated into NAAG by isolated spinal cords and by cell cultures of cortical astrocytes [13].
  • Naturally induced secretions from infective juveniles of the potato cyst nematode Globodera rostochiensis co-stimulate the proliferation of tobacco leaf protoplasts in the presence of the synthetic phytohormones alpha-naphthaleneacetic acid (NAA) and 6-benzylaminopurine (BAP) [14].
  • The results show that rat liver microsomes glucuronidate 1-naphthylacetic acid more efficiently than its regioisomer (higher Vmax/Km ratio because of a 6-fold lower Km value) [15].
  • The activity in cells cultured in TE-inductive medium that contained both NAA and BA increased very rapidly between the 48th and 60th hours of culture, when the number of TE increased rapidly [16].
  • The activity of antioxidant enzymes was also seriously affected by PGRs; SOD significantly decreased in the liver, heart, kidney, and brain of rats treated with both dosages of NAA, whereas the SOD activity in the erythrocytes, liver, and heart was either significantly decreased or not changed with two doses of 2,4-D and TIBA [17].

Associations of Agronaa with other chemical compounds


Gene context of Agronaa

  • The expressed ABP1 also appears to be active, since extracts of insect cells expressing ABP1 contain a saturable high-affinity 1-naphthylacetic acid-binding site, whereas no saturable auxin-binding activity is detected in extracts from control cells [23].
  • Addition of casein hydrolysate and coconut water to NAA supplemented medium showed better proliferation and production of callus [24].

Analytical, diagnostic and therapeutic context of Agronaa


  1. Two functional soybean genes encoding p34cdc2 protein kinases are regulated by different plant developmental pathways. Miao, G.H., Hong, Z., Verma, D.P. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  2. Contact urticaria to naphthylacetic acid. Camarasa, J.G. Contact Derm. (1986) [Pubmed]
  3. Short-term toxicity of 1-naphthaleneacetic acid in rats. Verschuuren, H.G., Kroes, R., den Tonkelaar, E.M., van Esch, G.J., Helleman, P.W. Toxicology (1976) [Pubmed]
  4. Therapy of primary biliary cirrhosis with p-tolylmethylcarbinol nicotinic acid ester in combination with alpha-naphthylacetic acid. Kaserbacher, R., Propst, A., Vogel, W. Wien. Klin. Wochenschr. (1996) [Pubmed]
  5. Molecular cloning and structural analysis of a gene from Zea mays (L.) coding for a putative receptor for the plant hormone auxin. Hesse, T., Feldwisch, J., Balshüsemann, D., Bauw, G., Puype, M., Vandekerckhove, J., Löbler, M., Klämbt, D., Schell, J., Palme, K. EMBO J. (1989) [Pubmed]
  6. Characterization of an Arabidopsis enzyme family that conjugates amino acids to indole-3-acetic acid. Staswick, P.E., Serban, B., Rowe, M., Tiryaki, I., Maldonado, M.T., Maldonado, M.C., Suza, W. Plant Cell (2005) [Pubmed]
  7. AUX1 promotes lateral root formation by facilitating indole-3-acetic acid distribution between sink and source tissues in the Arabidopsis seedling. Marchant, A., Bhalerao, R., Casimiro, I., Eklöf, J., Casero, P.J., Bennett, M., Sandberg, G. Plant Cell (2002) [Pubmed]
  8. Molecular and biochemical evidence for the involvement of calcium/calmodulin in auxin action. Yang, T., Poovaiah, B.W. J. Biol. Chem. (2000) [Pubmed]
  9. Lignification in cell suspension cultures of Pinus taeda. In situ characterization of a gymnosperm lignin. Eberhardt, T.L., Bernards, M.A., He, L., Davin, L.B., Wooten, J.B., Lewis, N.G. J. Biol. Chem. (1993) [Pubmed]
  10. Plasmid profiles as indicators of the source of contamination of Staphylococcus aureus endemic within poultry processing plants. Dodd, C.E., Chaffey, B.J., Waites, W.M. Appl. Environ. Microbiol. (1988) [Pubmed]
  11. Calreticulin expression in plant cells: developmental regulation, tissue specificity and intracellular distribution. Borisjuk, N., Sitailo, L., Adler, K., Malysheva, L., Tewes, A., Borisjuk, L., Manteuffel, R. Planta (1998) [Pubmed]
  12. Histological observations of morphogenesis in petiole derived callus of Amorphophallus rivieri Durieu in vitro. Hu, J.B., Liu, J., Yan, H.B., Xie, C.H. Plant Cell Rep. (2005) [Pubmed]
  13. Biosynthesis of NAAG by an enzyme-mediated process in rat central nervous system neurons and glia. Gehl, L.M., Saab, O.H., Bzdega, T., Wroblewska, B., Neale, J.H. J. Neurochem. (2004) [Pubmed]
  14. Naturally induced secretions of the potato cyst nematode co-stimulate the proliferation of both tobacco leaf protoplasts and human peripheral blood mononuclear cells. Goverse, A., Rouppe van der Voort, J., Roppe van der Voort, C., Kavelaars, A., Smant, G., Schots, A., Bakker, J., Helder, J. Mol. Plant Microbe Interact. (1999) [Pubmed]
  15. Substrate specificity and enantioselectivity of arylcarboxylic acid glucuronidation. Fournel-Gigleux, S., Hamar-Hansen, C., Motassim, N., Antoine, B., Mothe, O., Decolin, D., Caldwell, J., Siest, G. Drug Metab. Dispos. (1988) [Pubmed]
  16. Transient and specific expression of a cysteine endopeptidase associated with autolysis during differentiation of Zinnia mesophyll cells into tracheary elements. Minami, A., Fukuda, H. Plant Cell Physiol. (1995) [Pubmed]
  17. Influence of subacute treatment of some plant growth regulators on serum marker enzymes and erythrocyte and tissue antioxidant defense and lipid peroxidation in rats. Celik, I., Tuluce, Y., Isik, I. J. Biochem. Mol. Toxicol. (2006) [Pubmed]
  18. Expression of AtPRP3, a proline-rich structural cell wall protein from Arabidopsis, is regulated by cell-type-specific developmental pathways involved in root hair formation. Bernhardt, C., Tierney, M.L. Plant Physiol. (2000) [Pubmed]
  19. Effects of exogenous materials on pollen tube growth in Lilium longiflorum pistils. Ascher, P.D. Environ. Health Perspect. (1981) [Pubmed]
  20. Mutants of Nicotiana plumbaginifolia with specific resistance to auxin. Blonstein, A.D., Stirnberg, P., King, P.J. Mol. Gen. Genet. (1991) [Pubmed]
  21. Sugarcane white leaf phytoplasma in tissue culture: long-term maintenance, transmission, and oxytetracycline remission. Wongkaew, P., Fletcher, J. Plant Cell Rep. (2004) [Pubmed]
  22. Levels and immunolocalization of endogenous cytokinins in thidiazuron-induced shoot organogenesis in carnation. Casanova, E., Valdés, A.E., Fernández, B., Moysset, L., Trillas, M.I. J. Plant Physiol. (2004) [Pubmed]
  23. Authentic processing and targeting of active maize auxin-binding protein in the baculovirus expression system. Macdonald, H., Henderson, J., Napier, R.M., Venis, M.A., Hawes, C., Lazarus, C.M. Plant Physiol. (1994) [Pubmed]
  24. Proliferation potential of 18-month-old callus of Ananas comosus L. cv. Moris. De Silva, A.E., Kadir, M.A., Aziz, M.A., Kadzimin, S. ScientificWorldJournal (2006) [Pubmed]
  25. Determination of naphthaleneacetic acid residue in apples by high-performance liquid chromatography. Maiti, B., Desai, S.R., Krishnamoorthy, T.S. The Analyst. (1988) [Pubmed]
  26. Agrobacterium-mediated transformation of niger [ Guizotia abyssinica (L. f.) Cass.] using seedling explants. Murthy, H.N., Jeong, J.H., Choi, Y.E., Paek, K.Y. Plant Cell Rep. (2003) [Pubmed]
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