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Chemical Compound Review

CTK8H0959     [5-(6-aminopurin-9-yl)-4- hydroxy-2...

Synonyms: AR-1L3791, AC1L1A2K, AC1Q68Z7
 
 
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Disease relevance of isobutyryl-coenzyme A

  • Cloning, sequencing, expression, and insertional inactivation of the gene for the large subunit of the coenzyme B12-dependent isobutyryl-CoA mutase from Streptomyces cinnamonensis [1].
 

High impact information on isobutyryl-coenzyme A

  • IBD has a shorter and wider substrate-binding cavity relative to short-chain acyl-CoA dehydrogenase, permitting the optimal binding of the isobutyryl-CoA substrate [2].
  • Isobutyryl-CoA mutase (ICM) catalyzes the reversible, coenzyme B(12)-dependent rearrangement of isobutyryl-CoA to n-butyryl-CoA, which is similar to, but distinct from, that catalyzed by methylmalonyl-CoA mutase [3].
  • The first, via branched-chain alpha-ketoacid dehydrogenase to isobutyryl-CoA is not required for the synthesis of isobutyl alcohol because abolition of branched-chain alpha-ketoacid dehydrogenase activity in an lpd1 disruption mutant did not prevent the formation of isobutyl alcohol [4].
  • However, the oxidation rate of isobutyryl coenzyme A in the presence of l(-)-carnitine is very low and can be negligible in both rat and beef liver mitochondria [5].
  • Solvent polarity effects and limited acid catalysis in rearrangements of model radicals for the methylmalonyl-CoA mutase- and isobutyryl-CoA mutase-catalyzed isomerization reactions [6].
 

Gene context of isobutyryl-coenzyme A

References

  1. Cloning, sequencing, expression, and insertional inactivation of the gene for the large subunit of the coenzyme B12-dependent isobutyryl-CoA mutase from Streptomyces cinnamonensis. Zerbe-Burkhardt, K., Ratnatilleke, A., Philippon, N., Birch, A., Leiser, A., Vrijbloed, J.W., Hess, D., Hunziker, P., Robinson, J.A. J. Biol. Chem. (1998) [Pubmed]
  2. Structures of isobutyryl-CoA dehydrogenase and enzyme-product complex: comparison with isovaleryl- and short-chain acyl-CoA dehydrogenases. Battaile, K.P., Nguyen, T.V., Vockley, J., Kim, J.J. J. Biol. Chem. (2004) [Pubmed]
  3. Cloning and sequencing of the coenzyme B(12)-binding domain of isobutyryl-CoA mutase from Streptomyces cinnamonensis, reconstitution of mutase activity, and characterization of the recombinant enzyme produced in Escherichia coli. Ratnatilleke, A., Vrijbloed, J.W., Robinson, J.A. J. Biol. Chem. (1999) [Pubmed]
  4. An investigation of the metabolism of valine to isobutyl alcohol in Saccharomyces cerevisiae. Dickinson, J.R., Harrison, S.J., Hewlins, M.J. J. Biol. Chem. (1998) [Pubmed]
  5. Studies on the oxidation of isobutyrylcarnitine by beef and rat liver mitochondria. Choi, Y.R., Clarke, P.R., Bieber, L.L. J. Biol. Chem. (1979) [Pubmed]
  6. Solvent polarity effects and limited acid catalysis in rearrangements of model radicals for the methylmalonyl-CoA mutase- and isobutyryl-CoA mutase-catalyzed isomerization reactions. Daublain, P., Horner, J.H., Kuznetsov, A., Newcomb, M. J. Am. Chem. Soc. (2004) [Pubmed]
  7. Substrate stereochemistry of 2-methyl-branched-chain acyl-CoA dehydrogenase: elimination of one hydrogen each from (pro-2S)-methyl and alpha-methine of isobutyryl-CoA. Tanaka, K., O'Shea, J.J., Finocchiaro, G., Ikeda, Y., Aberhart, D.J., Ghoshal, P.K. Biochim. Biophys. Acta (1986) [Pubmed]
 
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