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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

AGN-PC-00Q6E3     4,5,6,7-tetrahydroxy-2-oxo-8- phosphonooxy...

Synonyms: AC1L1A3B
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Disease relevance of KDO-8P


High impact information on KDO-8P


Analytical, diagnostic and therapeutic context of KDO-8P


  1. A single point mutation in 3-deoxy-D-manno-octulosonate-8-phosphate synthase is responsible for temperature sensitivity in a mutant strain of Salmonella typhimurium. Taylor, W.P., Sheflyan, G.Y., Woodard, R.W. J. Biol. Chem. (2000) [Pubmed]
  2. Substrate and metal complexes of 3-deoxy-D-manno-octulosonate-8-phosphate synthase from Aquifex aeolicus at 1.9-A resolution. Implications for the condensation mechanism. Duewel, H.S., Radaev, S., Wang, J., Woodard, R.W., Gatti, D.L. J. Biol. Chem. (2001) [Pubmed]
  3. Probing the role of metal ions in the catalysis of Helicobacter pylori 3-deoxy-D-manno-octulosonate-8-phosphate synthase using a transient kinetic analysis. Sau, A.K., Li, Z., Anderson, K.S. J. Biol. Chem. (2004) [Pubmed]
  4. Effect of altered lipid A synthesis on the synthesis of the OmpA protein in Salmonella typhimurium. Rick, P.D., Neumeyer, B.A., Young, D.A. J. Biol. Chem. (1983) [Pubmed]
  5. Crystal structure of the reaction complex of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Thermotoga maritima refines the catalytic mechanism and indicates a new mechanism of allosteric regulation. Shumilin, I.A., Bauerle, R., Wu, J., Woodard, R.W., Kretsinger, R.H. J. Mol. Biol. (2004) [Pubmed]
  6. Mechanistic insight into 3-deoxy-D-manno-octulosonate-8-phosphate synthase and 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase utilizing phosphorylated monosaccharide analogues. Howe, D.L., Sundaram, A.K., Wu, J., Gatti, D.L., Woodard, R.W. Biochemistry (2003) [Pubmed]
  7. Relationship between cell death and altered lipid A synthesis in a temperature-sensitive lethal mutant of Salmonella typhimurium that is conditionally defective in 3-deoxy-D-manno-octulosonate-8-phosphate synthesis. Rick, P.D., Young, D.A. J. Bacteriol. (1982) [Pubmed]
  8. 3-Deoxy-D-manno-octulosonate-8-phosphate (KDO-8-P) phosphatase. Ray, P.H., Benedict, C.D. Meth. Enzymol. (1982) [Pubmed]
  9. Crystallization and preliminary crystallographic studies of 3-deoxy-D-manno-octulosonate-8-phosphate synthase from Escherichia coli. Tolbert, W.D., Moll, J.R., Bauerle, R., Kretsinger, R.H. Proteins (1996) [Pubmed]
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