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Chemical Compound Review:

AGN-PC-00Q6E3 4,5,6,7-tetrahydroxy-2-oxo-8- phosphonooxy...

Synonyms: AC1L1A3B

Taylor, W.P. et al., Rick, P.D. et al., Duewel, H.S. et al., Shumilin, I.A. et al., Rick, P.D. et al., et al.

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Disease relevance of KDO-8P

A single point mutation in 3-deoxy-D-manno-octulosonate-8-phosphate synthase is responsible for temperature sensitivity in a mutant strain of Salmonella typhimurium [1].
3-Deoxy-D-manno-octulosonate-8-phosphate synthase (KDO8PS) from the hyperthermophilic bacterium Aquifex aeolicus differs from its Escherichia coli counterpart in the requirement of a divalent metal for activity (Duewel, H. S., and Woodard, R. W. (2000) J. Biol. Chem. 275, 22824-22831) [2].
Probing the role of metal ions in the catalysis of Helicobacter pylori 3-deoxy-D-manno-octulosonate-8-phosphate synthase using a transient kinetic analysis [3].
Salmonella typhimurium mutants conditionally deficient in 3-deoxy-d-manno-octulosonate-8-phosphate (KDO8P) synthase activity play a central role in our understanding of lipopolysaccharide function in enteric bacteria [1].

High impact information on KDO-8P

The defect is due to a mutation in the structural gene for 3-deoxy-D-manno-octulosonate-8-phosphate synthetase (designated kdsA), and expression of this lesion results in the accumulation of an incomplete precursor of lipid A (Rick, P.D., and Osborn, M.J. (1977) J. Biol. Chem. 252, 4895-4903) [4].
However, the secondary, tertiary, and quaternary structures of DAHPS(Tm) are more similar to the functionally related enzyme, 3-deoxy-d-manno-octulosonate-8-phosphate synthase (KDOPS) from E.coli and Aquiflex aeolicus, than to DAHPS(Ec) and DAHPS(Sc) [5].
Mechanistic insight into 3-deoxy-D-manno-octulosonate-8-phosphate synthase and 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase utilizing phosphorylated monosaccharide analogues [6].
Relationship between cell death and altered lipid A synthesis in a temperature-sensitive lethal mutant of Salmonella typhimurium that is conditionally defective in 3-deoxy-D-manno-octulosonate-8-phosphate synthesis [7].
3-Deoxy-D-manno-octulosonate-8-phosphate (KDO-8-P) phosphatase [8].

Analytical, diagnostic and therapeutic context of KDO-8P

Crystallization and preliminary crystallographic studies of 3-deoxy-D-manno-octulosonate-8-phosphate synthase from Escherichia coli [9].

References

A single point mutation in 3-deoxy-D-manno-octulosonate-8-phosphate synthase is responsible for temperature sensitivity in a mutant strain of Salmonella typhimurium. Taylor, W.P., Sheflyan, G.Y., Woodard, R.W. J. Biol. Chem. (2000) [Pubmed]
Substrate and metal complexes of 3-deoxy-D-manno-octulosonate-8-phosphate synthase from Aquifex aeolicus at 1.9-A resolution. Implications for the condensation mechanism. Duewel, H.S., Radaev, S., Wang, J., Woodard, R.W., Gatti, D.L. J. Biol. Chem. (2001) [Pubmed]
Probing the role of metal ions in the catalysis of Helicobacter pylori 3-deoxy-D-manno-octulosonate-8-phosphate synthase using a transient kinetic analysis. Sau, A.K., Li, Z., Anderson, K.S. J. Biol. Chem. (2004) [Pubmed]
Effect of altered lipid A synthesis on the synthesis of the OmpA protein in Salmonella typhimurium. Rick, P.D., Neumeyer, B.A., Young, D.A. J. Biol. Chem. (1983) [Pubmed]
Crystal structure of the reaction complex of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Thermotoga maritima refines the catalytic mechanism and indicates a new mechanism of allosteric regulation. Shumilin, I.A., Bauerle, R., Wu, J., Woodard, R.W., Kretsinger, R.H. J. Mol. Biol. (2004) [Pubmed]
Mechanistic insight into 3-deoxy-D-manno-octulosonate-8-phosphate synthase and 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase utilizing phosphorylated monosaccharide analogues. Howe, D.L., Sundaram, A.K., Wu, J., Gatti, D.L., Woodard, R.W. Biochemistry (2003) [Pubmed]
Relationship between cell death and altered lipid A synthesis in a temperature-sensitive lethal mutant of Salmonella typhimurium that is conditionally defective in 3-deoxy-D-manno-octulosonate-8-phosphate synthesis. Rick, P.D., Young, D.A. J. Bacteriol. (1982) [Pubmed]
3-Deoxy-D-manno-octulosonate-8-phosphate (KDO-8-P) phosphatase. Ray, P.H., Benedict, C.D. Meth. Enzymol. (1982) [Pubmed]
Crystallization and preliminary crystallographic studies of 3-deoxy-D-manno-octulosonate-8-phosphate synthase from Escherichia coli. Tolbert, W.D., Moll, J.R., Bauerle, R., Kretsinger, R.H. Proteins (1996) [Pubmed]

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