Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Niagathal 4,5,6,7- tetrachloroisobenzofuran-1,3- dione

Synonyms: Tetrathal, PubChem20567, NSC-1484, ACMC-1BQJK, CCRIS 6202, ...

Gerhardsson, L. et al., Venables, K.M. et al., Venables, K.M. et al.

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High impact information on CP 626

Four patients with asthma caused by occupational exposure to tetrachlorophthalic anhydride (TCPA) had dust-challenge tests that used eight different levels of TCPA exposure [1].
In 1981 four patients had inhalation tests with TCPA, and specific IgE rose afterward and then fell again [2].
Levels of IgG against TM-HSA and HSA-conjugates of other acid anhydrides, phthalic anhydride (PA), maleic anhydride (MA), hexahydrophthalic anhydride (HHPA) and tetrachlorophthalic anhydride (TCPA) were estimated by enzyme-linked immunosorbent assay index [3].

Analytical, diagnostic and therapeutic context of CP 626

Specific IgE antibody to TCPA conjugated with human serum albumin was measured by a radioallergosorbent test and detected in all patients [2].

References

Exposure-response relationships in asthma caused by tetrachlorophthalic anhydride. Venables, K.M., Newman Taylor, A.J. J. Allergy Clin. Immunol. (1990) [Pubmed]
Immunologic and functional consequences of chemical (tetrachlorophthalic anhydride)-induced asthma after four years of avoidance of exposure. Venables, K.M., Topping, M.D., Nunn, A.J., Howe, W., Newman Taylor, A.J. J. Allergy Clin. Immunol. (1987) [Pubmed]
Immunologic specificity of IgG against trimellityl-human serum albumin in serum samples of workers exposed to trimellitic anhydride. Gerhardsson, L., Grammer, L.C., Shaughnessy, M.A., Patterson, R. J. Lab. Clin. Med. (1993) [Pubmed]

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