Disease relevance of MALEIC ANHYDRIDE

• In contrast, alkalinization did not inhibit the ability of polyinosinic:polycytidylic acid and poly-L-lysine stabilized in carboxymethyl cellulose, maleic anhydride divinyl ether, or Propionibacterium acnes to augment liver-associated natural killer activity [1].
• Chemical inactivation of Escherichia coli 30 S ribosomes with maleic anhydride: identification of the proteins involved in polyuridylic acid binding [2].
• To understand the role that these basic amino acid residues play in toxicity, STII was chemically modified with ethoxyformic anhydride, maleic anhydride, and phenylglyoxal, which alter the side chains of basic amino acid residues in proteins [3].
• It was found that the affinity of a monoclonal antibody directed against a recombinantly expressed HIV-1 capsid protein p24 (rp24) strongly increased after chemical modification of the Iysine residues of rp24 with different amounts of maleic anhydride [4].
• Various N-arylmaleimidobenzoic acids (MBA) were elaborated onto Rink and SASRIN resins by reaction of the aniline precursors with maleic anhydride followed by facile cyclative dehydration of the resulting maleimic acids [5].

High impact information on MALEIC ANHYDRIDE

• Bovine 6S procarboxypeptidase A can be dissociated into its three subunits by acylation with dimethyl maleic anhydride [6].
• Antitumor activity of tumor necrosis factor alpha conjugated with divinyl ether and maleic anhydride copolymer on solid tumors in mice [7].
• Carbetimer, an intermediate molecular-weight-derivatized copolymer of maleic anhydride and ethylene, has been shown to possess significant antineoplastic activity in the stem cell assay [8].
• With divinylether maleic anhydride copolymer macrophages, TPA enhanced cytotoxicity in a dose-dependent manner in the concentration range of 1.7 to 170 nM at macrophage: tumor cell ratios of 10:1 and 1:1 [9].
• TPA in the range of 10(-9) to 10(-7) M produced a dose- and time-related increase in chemotaxis in resident, thioglycollate-elicited, and divinyl ether maleic anhydride copolymer-activated macrophages [10].

Chemical compound and disease context of MALEIC ANHYDRIDE

• Chronic toxicity of styrene maleic anhydride, a male contraceptive, in rhesus monkeys (Macaca mulatta) [11].
• Some years ago it was found that the binding of sarcolysin to the copolymer of vinylpyrrolidone and maleic anhydride results in changes of some its pharmacological properties including toxicity, antitumor activity and immune suppression [12].

Biological context of MALEIC ANHYDRIDE

• Modification of all the lysines on adrenodoxin with maleic anhydride had no effect on the interaction with either adrenodoxin reductase or cytochrome P-450scc, suggesting that the lysines are not located at the binding site for either protein [13].
• The rigid polyampholyte blocks were formed by hydrolysis of alternating copolymers of N,N,N',N'-tetraethyl-4,4'-diaminostilbene with maleic anhydride, and the flexible coil block consists of poly(oligo(ethylene glycol)methacrylate) [14].
• The kinetics of the stereoselective semi-hydrogenation of 4-octyne in THF by the highly active catalyst [Pd{(m,m'-(CF(3))(2)C(6)H(3))-bian}(ma)] (2) (bian = bis(imino)acenaphthene; ma = maleic anhydride) has been investigated [15].
• Our new method allows airborne maleic anhydride to be determined with a limit of quantification of 1 microg/m3 per 12 1 of air, i.e., the concentration of about 0.01 times the occupational exposure standard (0.4 mg/m3) [16].
• To address this problem, we suggest a novel maleic anhydride copolymer precoating technique which allows for the covalent attachment of cellulose thin films through esterification [17].

Anatomical context of MALEIC ANHYDRIDE

• Renca is moderately sensitive to lysis by natural killer cells from normal mice and is more efficiently lysed by natural killer cells from mice treated with the biological response modifier maleic anhydride divinyl ether, a pyran copolymer [18].
• Pyran Copolymer (NSC-46015), a divinyl-ether maleic anhydride leads to a significant shift in distribution of nucleated cells and CFUs in the bone marrow and spleen [19].
• 3-(4-Alkylbenzoyl)acrylic acids (ABAAs) were synthesized by acylation of alkylbenzenes with maleic anhydride and then screened in vitro for inhibition of phospholipase A2 (PLA2) from snake venom and from porcine pancreas [20].
• An alternate co-polymer of styrene and maleic anhydride was dissolved in dimethylsulphoxide and injected into the vas deferens of rats [21].
• Differential solubilization of human erythrocyte cell membrane proteins by maleic anhydride [22].

Associations of MALEIC ANHYDRIDE with other chemical compounds

• Chemical modification of L-asparaginase with comb-shaped copolymer of poly(ethylene glycol) derivative and maleic anhydride [23].
• Shell-crosslinked nanostructures having unusual rosette morphologies have been produced by a simple process from styrene and maleic anhydride [24].
• Treatment of Trypticase peptides with acetic anhydride, succinic anhydride, or maleic anhydride inhibited their breakdown to ammonia by rumen microorganisms by an average of 89% after 12 h of incubation in vitro [25].
• Coated reactive carriers based on copolymers of 1-vinyl-2-pyrrolidone and maleic anhydride for immobilization of enzymes [26].
• We evaluated Gelfoam and monoisopropyl ester of poly(vinyl methyl ether/maleic anhydride) (PVM/MA) as potential polymers for ocular inserts [27].

Gene context of MALEIC ANHYDRIDE

• TM was covalently immobilized through poly(ethylene glycol) (PEG) spacers onto thin films of poly(octadecene alt maleic anhydride) covering planar glass substrates [28].
• This letter describes how the irreversible attachment of bovine serum albumin (BSA) to films of plasma-polymerized maleic anhydride can be measured by an indirect antibody-binding assay and how this attachment appears to be strongly affected by the polymerization conditions [29].
• Fibronectin adsorption and exchange on two different maleic anhydride copolymer surfaces differing in hydrophobicity and surface charge density have been analyzed by quartz crystal microbalance and laser scanning microscopy with respect to adsorbed amounts, viscoelastic properties, and conformation [30].
• The last is one of three products from the reaction of Fe(CO)(4)(MA) (MA = maleic anhydride) with NPP, the other two being Fe(CO)(3)(NPP) (7; P, P coordinated) and the unusual cyclic ylid Ph2PC(2-C5H4N)PPh2C(CH2CO2H)C(=O)(5) [31].
• The monomer mixture was composed of UEDMA, HEMA or TEGDMA, and 0-40 mol% HEMAN (the adduct of HEMA and maleic anhydride) [32].

Analytical, diagnostic and therapeutic context of MALEIC ANHYDRIDE

• Synthesis of a poly(vinylpyrrolidone-co-dimethyl maleic anhydride) co-polymer and its application for renal drug targeting [33].
• Approximately 80% of the water-soluble polymer poly(vinylpyrrolidone-co-dimethyl maleic anhydride selectively accumulated in the kidney of mice 24 h after intravenous injection [34].
• However, although the native enzyme has a sedimentation coefficient of 5.8S, dissociation by S-carboxymethylation and maleic anhydride treatment results in subunits exhibiting a single schlieren boundary on analytical ultracentrifugation with a sedimentation coefficient of 2.18S [35].
• Feeding experiments using a deuterium labeled C16 maleic anhydride and whole cell culture of ATCC 74256 led to the isolation of phomoidride B with deuterium incorporation at C(7) and C(19) as determined by 2H NMR and electrospray mass spectrometry [36].
• The solid-state structure of CoRu(CO)4(mu-bma)(mu-PPh2) (3a), as determined by X-ray crystallography, reveals that the two PPh2 groups are bound to the ruthenium center while the maleic anhydride pi bond is coordinated to the cobalt atom [37].

References