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Chemical Compound Review:

Dioctyl phthalate dioctyl benzene-1,2-dicarboxylate

Synonyms: DNOP, Vinicizer 85, Polycizer 162, Dinopol NOP, SureCN23053, ...

Oishi, S., Reddy, B.S. et al., Sanborn, J.R. et al., Guo, B.Y. et al.

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Disease relevance of Dioctyl phthalate

The correlation between the concentrations of PEs and different severity of endometriosis was strong and statistically significant at P < 0.05 for all four compounds (DnBP: r=+0.73, P < 0.0001; BBP: r=+0.78, P < 0.0001; DnOP: r=+0.57, P < 0.0001 and DEHP: r=+0.44, P < 0.0014) [1].

High impact information on Dioctyl phthalate

The limits of detection for DMP, DEP, DBP, DEHP, and DnOP were found to be 0.050, 0.051, 0.052, 0.054, and 0.063 mg/kg, respectively [2].
On the other hand, MEHP and mono-n-octyl phthalate (MOP), a metabolite of DOP, inhibited the state 3 oxygen consumption down to a concentration of 0.065 mumole/ml [3].
Plasticizers in the environment: the fate of di-N-octyl phthalate (DOP) in two model ecosystems and uptake and metabolism of DOP by aquatic organisms [4].

Associations of Dioctyl phthalate with other chemical compounds

DEHP and di-n-octyl phthalate (DOP), a DEHP isomer which causes less severe testicular injury, did not inhibit the state 3 oxygen consumption up to 0.65 mumole/ml in vitro [3].

References

Association of phthalate esters with endometriosis in Indian women. Reddy, B.S., Rozati, R., Reddy, B.V., Raman, N.V. BJOG : an international journal of obstetrics and gynaecology. (2006) [Pubmed]
Separation and determination of phthalates by micellar electrokinetic chromatography. Guo, B.Y., Wen, B., Shan, X.Q., Zhang, S.Z., Lin, J.M. Journal of chromatography. A. (2005) [Pubmed]
Effects of phthalic acid esters on testicular mitochondrial functions in the rat. Oishi, S. Arch. Toxicol. (1990) [Pubmed]
Plasticizers in the environment: the fate of di-N-octyl phthalate (DOP) in two model ecosystems and uptake and metabolism of DOP by aquatic organisms. Sanborn, J.R., Metcalf, R.L., Yu, C.C., Lu, P.Y. Arch. Environ. Contam. Toxicol. (1975) [Pubmed]

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