Disease relevance of C acid

• The hppA gene of Helicobacter pylori encodes the class C acid phosphatase precursor [1].
• In fibroblasts from patients with Niemann-Pick diseases types A, B and C, acid phosphodiesterase activity was deficient whereas neutral activity was normal [2].
• Cloning, purification and crystallization of Bacillus anthracis class C acid phosphatase [3].
• Using Ogawa's medium at 37 degrees C, acid-fast bacteria were isolated from the biopsied specimen and identified by the DNA-DNA hybridization method as Mycobacterium avium [4].
• The molecular class C acid phosphatase of Chryseobacterium meningosepticum (OlpA) is a broad-spectrum nucleotidase with preferential activity on 5'-nucleotides [5].

High impact information on C acid

• Enzymes included: neutral alpha-glucosidase and lysosomal beta-galactosidase, N-acetyl-beta-glucosaminidase, cathepsin C, acid alpha-glucosidase, and acid cholesteryl esterase [6].
• Enzymes included: neutral alpha-glucosidase, and lysosomal N-acetyl-beta-glucosaminidase, beta-galactosidase, cathepsin C, acid alpha-glucosidase, and acid cholesteryl esterase [7].
• The class C acid phosphatase of Helicobacter pylori is a 5' nucleotidase [8].
• The bis 3-amino-1,5-naphthalenedisulfonic acid derivative was the most active compound, but less active than the bis 4-amino-5-hydroxynaphthalenedisulfonic acid analog in the assays that measure RT and syncytia inhibition [9].

Analytical, diagnostic and therapeutic context of C acid

• This is the first report of the crystallization of a class C acid phosphatase [10].

References