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Chemical Compound Review:

Cogentin (1R,5R)-3-benzhydryloxy-8- methyl-8...

Synonyms: Lopac-B-8262, AC1MMXWK, Cogentin (TN), CHEMBL85236, AG-K-26865, ...

This record was replaced with 6832.

Gatley, S.J., Duvoisin, R.C., al Jeshi, A. et al., Tourtellotte, W.W. et al.

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Disease relevance of Benzatropine

Parkinson's disease: Cogentin with Sinemet, a better response [1].
A patient with Meige syndrome associated with spasmodic torticollis was treated with benztropine mesylate (Cogentin) at doses of 12-16 mg daily [2].

High impact information on Benzatropine

Calculations for 11C L-deprenyl, cogentin, cocaine, N-methylspiperone, putrescine and 2-deoxy-D-glucose, assuming transfer limited to a single organ, gave the kidneys rather than the thyroid as critical organ in each case [3].
Intravenous benzotropine mesylate challenge in acute neuroleptic-induced dystonia [4].

References

Parkinson's disease: Cogentin with Sinemet, a better response. Tourtellotte, W.W., Potvin, A.R., Syndulko, K., Hirsch, S.B., Gilden, E.R., Potvin, J.H., Hansch, E.C. Prog. Neuropsychopharmacol. Biol. Psychiatry (1982) [Pubmed]
Meige syndrome: relief on high-dose anticholinergic therapy. Duvoisin, R.C. Clinical neuropharmacology. (1983) [Pubmed]
Estimation of upper limits on human radiation absorbed doses from carbon-11-labeled compounds. Gatley, S.J. J. Nucl. Med. (1993) [Pubmed]
Intravenous benzotropine mesylate challenge in acute neuroleptic-induced dystonia. al Jeshi, A., al Kaisi, H.H. Canadian journal of psychiatry. Revue canadienne de psychiatrie. (1998) [Pubmed]

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