Disease relevance of Torticollis

• Dystonia, usually torticollis and/or writer's cramp, occurs in most but not all affected patients and may occasionally be the only symptom of the disease [1].
• Dystonia (e.g. torticollis and writer's cramp) were not encountered, a finding which strongly suggests that many previous studies of 'essential tremor' were contaminated by cases of idiopathic or hereditary torsion dystonia [2].
• We studied 300 patients, 61% women, with mean age 49.7 years and mean duration of dystonia 7.8 years, to determine the demographic and clinical characteristics of cervical dystonia (CD) and its relationships to other movement disorders [3].
• We studied the effects on heart rate (HR) and mean arterial blood pressure (MAP) of electrically stimulating the thalamus and basal ganglia in awake humans undergoing neurosurgery for movement disorders (n = 13 Parkinson's disease, n = 1 myoclonic dystonia, n = 1 spasmodic torticollis) [4].
• METHODS: Sixty-five sera samples from 42 adults treated with botulinum A toxin for essential blepharospasm, hemifacial spasm, or spasmodic torticollis were analyzed via a sphere-linked immunodiagnostic assay for antibody production [5].

Psychiatry related information on Torticollis

• The patients had a variety of hyperkinetic movement disorders including dystonia (generalized and focal: axial, Meige syndrome, torticollis, blepharospasm, bruxism), Huntington disease (HD) or other choreas, tardive dyskinesia (TD) or akathisia, and Tourette syndrome [6].

High impact information on Torticollis

• Chlorzoxazone-induced spasmotic torticollis [7].
• Cerebrospinal fluid gamma-aminobutyric acid in spasmodic torticollis [8].
• Effect of L-glutamine and isoniazid on torticollis and segmental dystonia [9].
• Two groups totaling 67 patients with idiopathic focal, segmental, and generalized dystonia, including torticollis, were compared with normal controls to determine whether there was a difference in the frequency of A, B, and C locus human leukocyte (HLA) antigens [10].
• Lithium for spasmodic torticollis [11].

Chemical compound and disease context of Torticollis

• PET studies of cerebral glucose metabolism in idiopathic torticollis [12].
• Treatment of spasmodic torticollis with amantadine: a double-blind study [13].
• Trihexyphenidyl and torticollis [14].
• Ten patients with spasmodic torticollis participated in a double-blind crossover trial of amantadine hydrochloride for a period of 2 months each [13].
• Treatment of spasmodic torticollis with ethyl chloride [15].

Biological context of Torticollis

• Genetic loci for an "intermediate dystonia" phenotype and for torticollis, named DYT6 and DYT7 respectively, have recently been mapped in single families [16].
• Epidemiology and outcome of cervical dystonia (spasmodic torticollis) in Rochester, Minnesota [17].
• Exteroceptive reflexes in dystonia: a study of the recovery cycle of the R2 component of the blink reflex and of the exteroceptive suppression of the contracting sternocleidomastoid muscle in blepharospasm and torticollis [18].
• Reciprocal inhibition between forearm extensor and flexor muscles was tested by means of an H-reflex technique in patients with spasmodic torticollis and normal controls [19].
• Stereotactic and Functional Neurosurgery Resident Award: deep brain stimulation for generalized dystonia and spasmodic torticollis: rate and extent of postoperative improvement [20].

Anatomical context of Torticollis

• Cervical dystonia (CD) is a form of dystonia that involves neck muscles [21].
• Unilateral microinjection of histamine itself into the rat red nucleus produced dystonic postures (torticollis) in a dose-dependent manner, demonstrating that a histamine dysfunction could contribute to the pathophysiology of dystonia [22].
• This study tested whether doxorubicin chemomyectomy, direct injection of doxorubicin into the SCM to permanently remove muscle fibers, has the potential to be a nonsurgical, permanent treatment for cervical dystonia [23].
• The second patient, a 30-year-old man, presented with a torsion dystonia, spasmodic torticollis, and involuntary movements of the upper limbs, which appeared after 4 years of neuroleptic treatment [24].
• The effectiveness was studied in 735 cases, including cerebral palsy (212), dystonia (129), torticollis (66), spinal cord injury (169), and degenerative diseases (159) [25].

Gene context of Torticollis

• Benign paroxysmal torticollis of infancy: four new cases and linkage to CACNA1A mutation [26].
• While the serum prolactin level decreased in response to bromocriptine, no difference was found between the effects of placebo and bromocriptine on the symptoms of spasmodic torticollis [27].
• Dopamine D2 receptor imaging with iodine-123-iodobenzamide SPECT in idiopathic rotational torticollis [28].
• OBJECTIVES: Congenital muscular torticollis is a common and controversial condition in infancy [29].
• C1/C2 rotary subluxation due to spasmodic torticollis [30].

Analytical, diagnostic and therapeutic context of Torticollis

• METHODS: Using a structured interview format and videotape assessments of severity of dystonia in a retrospective fashion, detailed follow up information was obtained on 16 patients who underwent open label selective denervation for severe, disabling torticollis, refractory to injections of botulinum toxin [31].
• We studied resting cerebral glucose metabolism in 10 spasmodic torticollis patients and 10 healthy controls by using positron-emission tomography and [18F]2-fluoro-2-deoxy-D-glucose [32].
• We describe three patients with a late presentation of congenital muscular torticollis to emphasize that this non-dystonic type of torticollis has to be considered in the differential diagnosis of cervical dystonia, even in adult patients [33].
• This investigation supports a recent suggestion that organic and psychogenic torticollis might be distinguished by electrofocusing of the CSF-protein [34].
• A randomized double-blind cross-over study was performed to compare the efficacy of Tizanidine to that of placebo in the treatment of spasmodic torticollis [35].

References