The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

HK-2     1,2-diethyl-3-hydroxy- pyridin-4-one

Synonyms: CHEMBL72457, CP94, SureCN868431, CCRIS 9395, AG-D-37091, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of 115900-75-9


High impact information on 115900-75-9


Biological context of 115900-75-9


Associations of HK-2 with other chemical compounds

  • The uptake of D-lactate and butyrate by HK-2 cells was inhibited by MCT analogues and the classical MCT inhibitors alpha-cyano-4-hydroxycinnamate, pCMB, and phloretin [8].

Analytical, diagnostic and therapeutic context of 115900-75-9


  1. Cellular uptake and release of two contrasting iron chelators. Cable, H., Lloyd, J.B. J. Pharm. Pharmacol. (1999) [Pubmed]
  2. Modulation of GABA-mediated synaptic transmission by endogenous zinc in the immature rat hippocampus in vitro. Xie, X., Hider, R.C., Smart, T.G. J. Physiol. (Lond.) (1994) [Pubmed]
  3. Urinary metabolic profiles in human and rat of 1,2-dimethyl- and 1,2-diethyl-substituted 3-hydroxypyridin-4-ones. Singh, S., Epemolu, R.O., Dobbin, P.S., Tilbrook, G.S., Ellis, B.L., Damani, L.A., Hider, R.C. Drug Metab. Dispos. (1992) [Pubmed]
  4. The pharmacokinetics of 1,2-diethyl-3-hydroxypyridin-4-one (CP94) in rats. Epemolu, O.R., Singh, S., Hider, R.C., Damani, L.A. Drug Metab. Dispos. (1992) [Pubmed]
  5. A hydroxypyridinone (CP94) enhances protoporphyrin IX formation in 5-aminolaevulinic acid treated cells. Bech, O., Phillips, D., Moan, J., MacRobert, A.J. J. Photochem. Photobiol. B, Biol. (1997) [Pubmed]
  6. Contrasting interspecies efficacy and toxicology of 1,2-diethyl-3-hydroxypyridin-4-one, CP94, relates to differing metabolism of the iron chelating site. Porter, J.B., Abeysinghe, R.D., Hoyes, K.P., Barra, C., Huehns, E.R., Brooks, P.N., Blackwell, M.P., Araneta, M., Brittenham, G., Singh, S. Br. J. Haematol. (1993) [Pubmed]
  7. The efficacy of an iron chelator (CP94) in increasing cellular protoporphyrin IX following intravesical 5-aminolaevulinic acid administration: an in vivo study. Chang, S.C., MacRobert, A.J., Porter, J.B., Bown, S.G. J. Photochem. Photobiol. B, Biol. (1997) [Pubmed]
  8. Characterization of monocarboxylate transport in human kidney HK-2 cells. Wang, Q., Lu, Y., Yuan, M., Darling, I.M., Repasky, E.A., Morris, M.E. Mol. Pharm. (2006) [Pubmed]
  9. Pharmacokinetics of representative 3-hydroxypyridin-4-ones in rabbits: CP20 and CP94. Fredenburg, A.M., Wedlund, P.J., Skinner, T.L., Damani, L.A., Hider, R.C., Yokel, R.A. Drug Metab. Dispos. (1993) [Pubmed]
  10. High-performance liquid chromatographic determination of 1,2-diethyl-3-hydroxypyridin-4-one and its 2-(1-hydroxyethyl) metabolite in rat blood. Epemolu, R.O., Singh, S., Hider, R.C., Damani, L.A. J. Chromatogr. (1992) [Pubmed]
WikiGenes - Universities