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Chemical Compound Review:

PubChem15371 pyridine-2,6-diamine

Synonyms: SureCN64599, CHEMBL339234, NSC-1921, CCRIS 6682, D24404_ALDRICH, ...

Moghimi, A. et al., Rauckman, B.S. et al., Mibu, N. et al., Bikhazi, A.B. et al.

Moghimi, Alizadeh, Shokrollahi, Aghabozorg, Shamsipur, Shockravi,

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Disease relevance of 1/C5H7N3/c6-4-2-1-3-5(7)8-4/h1-3H,(H4,6,7,8

N-Monoacyl-2,6-diaminopyridines (2a-c) and N,N'-diacyl-2,6-diaminopyridines (3a-c) were synthesized from 2,6-diaminopyridine by acylation with the corresponding acyl halide or by dehydration with the corresponding carboxylic acid using 1,3-dicyclohexylcarbodiimide (DCC) [1].

High impact information on 1/C5H7N3/c6-4-2-1-3-5(7)8-4/h1-3H,(H4,6,7,8

2,6-Diaminopyridine is very readily dibenzylated at the 3,5 positions as well as on an amino group, by a phenolic Mannich base; use of a fourfold excess of the pyridine provided a 3-benzylated 2,6-diaminopyridine in 50% yield; this was inactive as an inhibitor of dihydrofolate reductase at 10(-4) M [2].
The new 1,10-phenanthroline containing 1:1 proton-transfer compound LH(2), [pyda.H(2)](2+)[phendc](2-), was synthesized from the reaction of 2,6-pyridinediamine, pyda, and 1,10-phenanthroline-2,9-dicarboxylic acid, phendc.H(2), and characterized by elemental analysis, ES-Ms, IR, (1)H, (13)C NMR, and UV/vis spectroscopies [3].

Analytical, diagnostic and therapeutic context of 1/C5H7N3/c6-4-2-1-3-5(7)8-4/h1-3H,(H4,6,7,8

A Sprague-Dawley rat kidney perfusion technique was used in situ to study the effects of cis-dichloro-diamine platinum, PdCl2 (2,6-diaminopyridine), and RhCl3 (2,6-diaminopyridine) on sodium and calcium retention in the whole kidney [4].

References

N-Long-chain Monoacylated Derivatives of 2,6-Diaminopyridine with Antiviral Activity. Mibu, N., Yokomizo, K., Kashige, N., Miake, F., Miyata, T., Uyeda, M., Sumoto, K. Chem. Pharm. Bull. (2007) [Pubmed]
2,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. 3. C-Benzylation of aminopyridines with phenolic Mannich bases. Synthesis of 1- and 3-deaza analogues of trimethoprim. Rauckman, B.S., Roth, B. J. Med. Chem. (1980) [Pubmed]
First anionic 1,10-phenanthroline-2,9-dicarboxylate containing metal complex obtained from a novel 1:1 proton-transfer compound: synthesis, characterization, crystal structure, and solution studies. Moghimi, A., Alizadeh, R., Shokrollahi, A., Aghabozorg, H., Shamsipur, M., Shockravi, A. Inorganic chemistry. (2003) [Pubmed]
Comparative nephrotoxic effects of cis-platinum (II), cis-palladium (II), and cis-rhodium (III) metal coordination compounds in rat kidneys. Bikhazi, A.B., Salameh, A., el-Kasti, M.M., Awar, R.A. Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. (1995) [Pubmed]

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