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Chemical Compound Review:

Acetonanil 2,2,4-trimethyl-1H-quinoline

Synonyms: Acetonanyl, DHTMQ, Antioxidant HS, Flectol A, Flectol H, ...

Sitarek, K. et al., Irwin, R.D. et al., Sitarek, K. et al., Ioannou, Y.M. et al.

Sitarek, Sapota,

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Disease relevance of Polnoks R

Evaluation of oral exposure to Polnoks R for female rats in developmental toxicity studies [1].
Maternal weight gain was reduced in the group receiving Polnoks R at the 670 mg/ kg dose [1].
Pregnant female rats were exposed to Polnoks R by gavage every day on days 6-15 of gestation at doses of 170, 340, and 670 mg/kg body weight (b,w) (6%, 13%, and 25% LD50) [1].

High impact information on Polnoks R

1,2-Dihydro-2,2,4-trimethylquinoline (TMQ), an antioxidant used in the rubber industry, was readily absorbed from the gastrointestinal tract of the male Fischer 344/N rat and rapidly distributed throughout the body tissues [2].
CONCLUSIONS: This study has demonstrated that transplacental exposure to Polnoks R monomer is teratogenic in rats [3].
The aim of the study was to evaluate prenatal development and tissue distribution in rats exposed to 2,2,4-trimethyl-1,2-dihydroquinoline (TMDHQ), a monomer of Polnoks R [3].

Analytical, diagnostic and therapeutic context of Polnoks R

1,2-Dihydro-2,2,4-trimethylquinoline (TMQ) was evaluated in a 2-year study in which groups of 60 male or female F344 rats received 0, 36 or 60 mg kg(-1) (0, 0.022, or 0.037 mg cm(-2)) and groups of 60 male or female B6C3F1 mice received 0, 3.6 or 10 mg kg(-1) (0, 0.00136, 0.00435 mg cm(-2)) in acetone by topical administration [4].

References

Evaluation of oral exposure to Polnoks R for female rats in developmental toxicity studies. Sitarek, K., Berlińska, B., Barański, B. Teratog., Carcinog. Mutagen. (1996) [Pubmed]
Absorption, distribution, metabolism, and excretion of 1,2-dihydro-2,2,4-trimethylquinoline in the male F344 rat. Ioannou, Y.M., Burka, L.T., Sanders, J.M., Moorman, M.P., Matthews, H.B. Drug Metab. Dispos. (1987) [Pubmed]
Maternal-fetal distribution and prenatal toxicity of 2,2,4-trimethyl-1,2-dihydroquinoline in the rat. Sitarek, K., Sapota, A. Birth Defects Res. B Dev. Reprod. Toxicol. (2003) [Pubmed]
Carcinogenicity of dermally administered 1,2-dihydro-2,2,4-trimethylquinoline monomer in F344 rats and B6C3F1 mice. Irwin, R.D., French, J.E., Elwell, M., Haseman, J., Braun, A.G., Voelker, F.A. Journal of applied toxicology : JAT. (1999) [Pubmed]

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