Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AMPCPP [[(2R,3S,4R,5R)-5-(6- aminopurin-9-yl)-3,4...

Synonyms: AOPCP, AMP-CP, CHEMBL583969, CHEBI:40730, M3763_SIGMA, ...

Sato, T. et al., Moyer, B.D. et al., Kather, H., Florio, C. et al., Ujházy, P. et al.

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High impact information on Adenosine 5'-methylenediphosphate

In addition, the cells possessed a nucleotide phosphomonoesterase that was resistant to the inhibitory actions of ATP and alpha,beta-methyleneadenosine 5'-diphosphate and showed preference for IMP over AMP [1].
An inhibitor of ecto-5'NT enzymatic activity, alpha,beta-methyleneadenosine 5'-diphosphate (AMP-CP), was used to determine if functionally active enzyme had a role in drug resistance [2].
Erythro-9-(2-hydroxy-3-nonyl)adenine (10 microM), an inhibitor of ADA, and alpha,beta-methyleneadenosine 5'-diphosphate (100 microM), an inhibitor of ecto-5'-nucleotidase, did not alter forskolin activity [3].
To identify the source(s) of extracellular adenosine, we examined the effects of dipyridamole, an inhibitor of nucleoside transport, and alpha,beta-methyleneadenosine 5'-diphosphate (AOPCP), an inhibitor of ecto-5'-nucleotidase, on AVP-stimulated IscCl [4].

Associations of Adenosine 5'-methylenediphosphate with other chemical compounds

Introduction of AMP (100 microM) through the probe increased the dialysate adenosine markedly to 9.79 +/- 0.43 microM (n = 12, P < 0.001 vs baseline), and this increase was inhibited by the ecto-5'-nucleotidase inhibitor, alpha,beta-methyleneadenosine 5'-diphosphate (100 microM), to 0.76 +/- 0.12 microM (n = 8) [5].

References

Pathways of purine metabolism in human adipocytes. Further evidence against a role of adenosine as an endogenous regulator of human fat cell function. Kather, H. J. Biol. Chem. (1990) [Pubmed]
Evidence for the involvement of ecto-5'-nucleotidase (CD73) in drug resistance. Ujházy, P., Berleth, E.S., Pietkiewicz, J.M., Kitano, H., Skaar, J.R., Ehrke, M.J., Mihich, E. Int. J. Cancer (1996) [Pubmed]
Involvement of P1 receptors in the effect of forskolin on cyclic AMP accumulation and export in PC12 cells. Florio, C., Frausin, F., Vertua, R., Gaion, R.M. Biochem. Pharmacol. (1999) [Pubmed]
Adenosine inhibits arginine vasopressin-stimulated chloride secretion in a mouse IMCD cell line (mIMCD-K2). Moyer, B.D., McCoy, D.E., Lee, B., Kizer, N., Stanton, B.A. Am. J. Physiol. (1995) [Pubmed]
The effect of glibenclamide on the production of interstitial adenosine by inhibiting ecto-5'-nucleotidase in rat hearts. Sato, T., Obata, T., Yamanaka, Y., Arita, M. Br. J. Pharmacol. (1997) [Pubmed]

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