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Gene Review

Nt5e  -  5' nucleotidase, ecto

Rattus norvegicus

Synonyms: 5'-NT, 5'-nucleotidase, CD73, Ecto-5'-nucleotidase, Nt5, ...
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Disease relevance of Nt5e


Psychiatry related information on Nt5e


High impact information on Nt5e


Chemical compound and disease context of Nt5e


Biological context of Nt5e


Anatomical context of Nt5e


Associations of Nt5e with chemical compounds

  • Using PCR we identified the mRNA of all members of the ecto-nucleoside triphosphate diphosphohydrolase family investigated (NTPDase1 to NTPDase3, NTPDase5/6), of ecto-nucleotide pyrophosphatase/phosphodiesterase3 (NPP3), tissue-non-specific alkaline phosphatase and ecto-5'-nucleotidase [22].
  • When ecto-5'-nucleotidase activity increased, adenosine release was augmented in methoxamine- and PMA-treated cardiomyocytes (1299 +/- 252% and 1372 +/- 149%, respectively) compared with the untreated group (578 +/- 26%) [9].
  • These increases in ecto-5'-nucleotidase activity were inhibited by GF109203X, an inhibitor of protein kinase C, and mimicked by phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C. The increase in ecto-5'-nucleotidase was not prevented by cycloheximide [9].
  • The conversion of cAMP to adenosine and inosine was inhibited by blockade of phosphodiesterase with IBMX, of ecto-phosphodiesterase with DPSPX, and of ecto-5'-nucleotidase with AMP-CP [17].
  • S-(p-nitrobenzyl)-6-thioinosine (NBTI) and dipyridamole were used as pharmacological tools to inhibit adenosine equilibrative transporters (ENT) and alpha,beta-methylene ADP (AOPCP) to inhibit ecto-5'-nucleotidase [10].

Regulatory relationships of Nt5e


Other interactions of Nt5e


Analytical, diagnostic and therapeutic context of Nt5e


  1. Thyroid hormone stimulates 5'-ecto-nucleotidase of neonatal rat ventricular myocytes. Carneiro-Ramos, M.S., da Silva, V.B., Coutinho, M.B., Battastini, A.M., Sarkis, J.J., Barreto-Chaves, M.L. Mol. Cell. Biochem. (2004) [Pubmed]
  2. Acidosis during ischemia promotes adenosine triphosphate resynthesis in postischemic rat heart. In vivo regulation of 5'-nucleotidase. Bak, M.I., Ingwall, J.S. J. Clin. Invest. (1994) [Pubmed]
  3. Ecto-5'-nucleotidase plays a role in the cardioprotective effects of heat shock protein 72 in ischemia-reperfusion injury in rat hearts. Sakaguchi, T., Sawa, Y., Kitakaze, M., Suzuki, K., Nishimura, M., Kaneda, Y., Matsuda, H. Cardiovasc. Res. (2000) [Pubmed]
  4. Modulation of seizures and synaptic plasticity by adenosinergic receptors in an experimental model of temporal lobe epilepsy induced by pilocarpine in rats. Vianna, E.P., Ferreira, A.T., Doná, F., Cavalheiro, E.A., da Silva Fernandes, M.J. Epilepsia (2005) [Pubmed]
  5. Manipulation of endogenous adenosine in the rat prepiriform cortex modulates seizure susceptibility. Zhang, G., Franklin, P.H., Murray, T.F. J. Pharmacol. Exp. Ther. (1993) [Pubmed]
  6. Adenosine kinase and 5'-nucleotidase activity after prolonged wakefulness in the cortex and the basal forebrain of rat. Alanko, L., Heiskanen, S., Stenberg, D., Porkka-Heiskanen, T. Neurochem. Int. (2003) [Pubmed]
  7. Mechanisms whereby extracellular adenosine 3',5'-monophosphate inhibits phosphate transport in cultured opossum kidney cells and in rat kidney. Physiological implication. Friedlander, G., Couette, S., Coureau, C., Amiel, C. J. Clin. Invest. (1992) [Pubmed]
  8. Role of activation of protein kinase C in the infarct size-limiting effect of ischemic preconditioning through activation of ecto-5'-nucleotidase. Kitakaze, M., Node, K., Minamino, T., Komamura, K., Funaya, H., Shinozaki, Y., Chujo, M., Mori, H., Inoue, M., Hori, M., Kamada, T. Circulation (1996) [Pubmed]
  9. Alpha 1-adrenoceptor activation increases ecto-5'-nucleotidase activity and adenosine release in rat cardiomyocytes by activating protein kinase C. Kitakaze, M., Hori, M., Morioka, T., Minamino, T., Takashima, S., Okazaki, Y., Node, K., Komamura, K., Iwakura, K., Itoh, T. Circulation (1995) [Pubmed]
  10. Hypoxia induces adenosine release from the rat carotid body. Conde, S.V., Monteiro, E.C. J. Neurochem. (2004) [Pubmed]
  11. Adenosine release in nucleus tractus solitarii does not appear to mediate hypoxia-induced respiratory depression in rats. Gourine, A.V., Llaudet, E., Thomas, T., Dale, N., Spyer, K.M. J. Physiol. (Lond.) (2002) [Pubmed]
  12. Stimulation of rat C6 glioma ecto-5'-nucleotidase by chronic ethanol treatment. Syapin, P.J., Stefanovic, V., Mandel, P., Noble, E.P. Biochem. Pharmacol. (1980) [Pubmed]
  13. Activation of ecto-5'-nucleotidase by protein kinase C attenuates irreversible cellular injury due to hypoxia and reoxygenation in rat cardiomyocytes. Kitakaze, M., Minamino, T., Node, K., Komamura, K., Inoue, M., Hori, M., Kamada, T. J. Mol. Cell. Cardiol. (1996) [Pubmed]
  14. Increased 5'-nucleotidase activity induced by dibutyryl cyclic AMP treatment of cultured glial cells. Amano, S., Hazama, F., Kawai, J., Sasahara, M. Brain Res. (1990) [Pubmed]
  15. Kinetic characterization of ATP diphosphohydrolase and 5'-nucleotidase activities in cells cultured from submandibular salivary glands of rats. Henz, S.L., Ribeiro, C.G., Rosa, A., Chiarelli, R.A., Casali, E.A., Sarkis, J.J. Cell Biol. Int. (2006) [Pubmed]
  16. Up-regulation of ectonucleotidase activity after cortical stab injury in rats. Nedeljkovic, N., Bjelobaba, I., Subasic, S., Lavrnja, I., Pekovic, S., Stojkov, D., Vjestica, A., Rakic, L., Stojiljkovic, M. Cell Biol. Int. (2006) [Pubmed]
  17. Cyclic AMP-adenosine pathway inhibits vascular smooth muscle cell growth. Dubey, R.K., Mi, Z., Gillespie, D.G., Jackson, E.K. Hypertension (1996) [Pubmed]
  18. Evaluation of rat liver apoptotic and necrotic cell death after cold storage using UW, HTK, and Celsior. Straatsburg, I.H., Abrahamse, S.L., Song, S.W., Hartman, R.J., Van Gulik, T.M. Transplantation (2002) [Pubmed]
  19. Identification of histidyl and cysteinyl residues essential for catalysis by 5'-nucleotidase. Worku, Y., Luzio, J.P., Newby, A.C. FEBS Lett. (1984) [Pubmed]
  20. Ecto-5'-nucleotidase does not catalyze vectorial production of adenosine in the perfused rat liver. Sasaki, T., Abe, A., Sakagami, T. J. Biol. Chem. (1983) [Pubmed]
  21. Inhibition of ecto-5'-nucleotidase by nitric oxide donors. Implications in renal epithelial cells. Siegfried, G., Amiel, C., Friedlander, G. J. Biol. Chem. (1996) [Pubmed]
  22. Multiple ecto-nucleotidases in PC12 cells: identification and cellular distribution after heterologous expression. Vollmayer, P., Koch, M., Braun, N., Heine, P., Servos, J., Israr, E., Kegel, B., Zimmermann, H. J. Neurochem. (2001) [Pubmed]
  23. Induction of ecto-5'-nucleotidase of rat cultured mesangial cells by interleukin-1 beta and tumour necrosis factor-alpha. Savic, V., Stefanovic, V., Ardaillou, N., Ardaillou, R. Immunology (1990) [Pubmed]
  24. Beta,gamma-methylene ATP-induced cAMP formation in C6Bu-1 cells: involvement of local metabolism and subsequent stimulation of adenosine A2B receptor. Ohkubo, S., Kumazawa, K., Sagawa, K., Kimura, J., Matsuoka, I. J. Neurochem. (2001) [Pubmed]
  25. Contribution of endothelium and cardiomyocytes to hypoxia-induced adenosine release. Raatikainen, M.J., Peuhkurinen, K.J., Hassinen, I.E. J. Mol. Cell. Cardiol. (1994) [Pubmed]
  26. Stimulation of alpha 1-adrenoceptors and protein kinase C-mediated activation of ecto-5'-nucleotidase in rat hearts in vivo. Sato, T., Obata, T., Yamanaka, Y., Arita, M. J. Physiol. (Lond.) (1997) [Pubmed]
  27. The soluble 'low-Km' 5'-nucleotidase of rat kidney represents solubilized ecto-5'-nucleotidase. Piec, G., Le Hir, M. Biochem. J. (1991) [Pubmed]
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