The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

PubChem7679     5,7-diazabicyclo[4.3.0]nona- 2,4,8,10-tetraene

Synonyms: zlchem 221, SureCN17837, CHEMBL389685, ACMC-1CKM0, A95502_ALDRICH, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of NSC 67063

 

High impact information on NSC 67063

  • Here we report observations of the femtosecond dynamics of tautomerization in model base pairs (7-azaindole dimers) containing two hydrogen bonds [2].
  • Upon N-H deuteration of the 7-azaindole dimer, the theoretical excited-state activation energy for the double deuterium transfer is determined to be 1.4 kcal/mol, in agreement with experiment, which in low-temperature spectroscopy is shown to negate excited-state double-deuteron transfer [3].
  • Two new classes of tricyclic-based corticotropin-releasing factor (CRF(1)) receptor-1 antagonists were designed by constraining known 1H-pyrrolo[2,3-b]pyridine and 1H-pyrazolo[3,4-b]pyridine ligands [4].
  • 7-Azaindole as the aromatic moiety afforded weak 5-HT3 receptor antagonists activity [5].
  • The tautomerization and the relaxation of excited 7-azaindole can be exploited to probe the nanopools of methanol reverse micelles [6].
 

Biological context of NSC 67063

  • The molecular structure and properties of 7-azaindole in its first four singlet states were studied with a view to improving current understanding of the photophysical behavior of its C(2h) dimer [7].
  • The excited-state proton-transfer dynamics of 7-azaindole occurring in the water nanopools of reverse micelles has been investigated by measuring time-resolved fluorescence spectra and kinetics, as well as static absorption and emission spectra, with varying water content and isotope [8].
 

Associations of NSC 67063 with other chemical compounds

  • Cu(I) and Zn(II) complexes of 7-azaindole-containing scorpionates: structures, luminescence and fluxionality [9].
  • Studies in representative homogeneous solvents and solvent-mixtures indicate that unlike other fluorophores of related interest like indole (I) and 7-azaindole (7AI), the fluorescence emission maximum (lambda(em)max) of 5HI is relatively insensitive to solvent polarity [10].
  • Synthesis and fluorescence study of 7-azaindole in DNA oligonucleotides replacing a purine base [11].

References

  1. Discovery of 4-benzoyl-1-[(4-methoxy-1H- pyrrolo[2,3-b]pyridin-3-yl)oxoacetyl]-2- (R)-methylpiperazine (BMS-378806): a novel HIV-1 attachment inhibitor that interferes with CD4-gp120 interactions. Wang, T., Zhang, Z., Wallace, O.B., Deshpande, M., Fang, H., Yang, Z., Zadjura, L.M., Tweedie, D.L., Huang, S., Zhao, F., Ranadive, S., Robinson, B.S., Gong, Y.F., Ricarrdi, K., Spicer, T.P., Deminie, C., Rose, R., Wang, H.G., Blair, W.S., Shi, P.Y., Lin, P.F., Colonno, R.J., Meanwell, N.A. J. Med. Chem. (2003) [Pubmed]
  2. Femtosecond molecular dynamics of tautomerization in model base pairs. Douhal, A., Kim, S.K., Zewail, A.H. Nature (1995) [Pubmed]
  3. H-bonded N-heterocyclic base-pair phototautomerizational potential barrier and mechanism: The 7-azaindole dimer. Catalán, J., Pérez, P., del Valle, J.C., de Paz, J.L., Kasha, M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  4. Potent, orally active corticotropin-releasing factor receptor-1 antagonists containing a tricyclic pyrrolopyridine or pyrazolopyridine core. Dyck, B., Grigoriadis, D.E., Gross, R.S., Guo, Z., Haddach, M., Marinkovic, D., McCarthy, J.R., Moorjani, M., Regan, C.F., Saunders, J., Schwaebe, M.K., Szabo, T., Williams, J.P., Zhang, X., Bozigian, H., Chen, T.K. J. Med. Chem. (2005) [Pubmed]
  5. New 5-HT3 (serotonin-3) receptor antagonists. IV. Synthesis and structure-activity relationships of azabicycloalkaneacetamide derivatives. Kato, M., Ito, K., Nishino, S., Yamakuni, H., Takasugi, H. Chem. Pharm. Bull. (1995) [Pubmed]
  6. Proton transfer of excited 7-azaindole in reverse-micellar methanol nanopools: even faster than in bulk methanol. Kwon, O.H., Jang, D.J. The journal of physical chemistry. B, Condensed matter, materials, surfaces, interfaces & biophysical. (2005) [Pubmed]
  7. Study of 7-azaindole in its first four singlet states. Catalán, J., de Paz, J.L. The Journal of chemical physics. (2005) [Pubmed]
  8. Excited-state double proton transfer of 7-azaindole in water nanopools. Kwon, O.H., Jang, D.J. The journal of physical chemistry. B, Condensed matter, materials, surfaces, interfaces & biophysical. (2005) [Pubmed]
  9. Cu(I) and Zn(II) complexes of 7-azaindole-containing scorpionates: structures, luminescence and fluxionality. Song, D., Jia, W.L., Wu, G., Wang, S. Dalton transactions (Cambridge, England : 2003) (2005) [Pubmed]
  10. Luminescence behaviour of 5-hydroxyindole in different environments. Sengupta, B., Guharay, J., Sengupta, P.K. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. (2000) [Pubmed]
  11. Synthesis and fluorescence study of 7-azaindole in DNA oligonucleotides replacing a purine base. Wang, K., Stringfellow, S., Dong, S., Jiao, Y., Yu, H. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. (2002) [Pubmed]
 
WikiGenes - Universities