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Chemical Compound Review:

Phenazine methosulfate 5-methylphenazine; sulfonatooxymethane

Synonyms: PubChem22152, CCRIS 5618, CHEBI:8055, AG-J-50214, P9625_SIGMA, ...

This record was replaced with 9286.

Duncan, C.J. et al., Kugler, P. et al., Goodwin, C.J. et al., Miyawaki, O. et al.

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Disease relevance of NSC403524

Phenazine methosulphate (PMS) triggers the production of conspicuous and characteristic sarcolemma blebs in mouse diaphragm skeletal muscle incubated in vitro and also causes severe myofilament damage [1].

High impact information on NSC403524

We demonstrate that MTS/PMS provides microculture tetrazolium assays for hGH which are free from these serious artefacts and which are uniquely precise [2].
The use of NaN3 (as a blocker of the respiratory chain) and PMS (as artificial electron carrier) was indispensible for the transfer of all reduction equivalents in the dehydrogenase reactions to the tetrazolium salt NBT [3].
It is suggested that PMS activates transmembrane NAD(P)H dehydrogenases and, in turn, a modification of sulphydryl groups of the cytoskeleton, thereby permitting bleb formation in contracting cells [1].

Analytical, diagnostic and therapeutic context of NSC403524

Electrochemical bioreactor with regeneration of NAD+ by rotating graphite disk electrode with PMS adsorbed [4].

References

Sarcolemma blebs and cell damage in mammalian skeletal muscle. Duncan, C.J., Shamsadeen, N. Tissue & cell. (1989) [Pubmed]
Microculture tetrazolium assays: a comparison between two new tetrazolium salts, XTT and MTS. Goodwin, C.J., Holt, S.J., Downes, S., Marshall, N.J. J. Immunol. Methods (1995) [Pubmed]
Microphotometric determination of enzymes in brain sections. IV. Isocitrate dehydrogenases. Kugler, P., Vogel, S. Histochemistry (1991) [Pubmed]
Electrochemical bioreactor with regeneration of NAD+ by rotating graphite disk electrode with PMS adsorbed. Miyawaki, O., Yano, T. Enzyme Microb. Technol. (1992) [Pubmed]

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