Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

Harpagide (1R,2S,6R,7R,9S)-9-methyl-2- [(2S,3R,4S,5S...

Synonyms: SureCN1425414, CHEBI:565328, KST-1A0302, STOCK1N-54126, AC1L3PDV, ...

Breschi, M.C. et al., Colas, C. et al., Occhiuto, F. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Harpagide

The aim of this work was to estimate the proton and sodium cation affinities of harpagide (Har), an iridoid glycoside responsible for the antiinflammatory properties of the medicinal plant Harpagophytum [1].
The H2O-soluble part of a crude and partially purified MeOH extract and two isolated iridoids (8-O-acetylharpagide and harpagide), were tested for a biological activity on isolated smooth muscle preparations from guinea pig [2].

Associations of Harpagide with other chemical compounds

Effects of the crude methanolic extract of Harpagophytum procumbens secondary roots and two of its active principles, harpagoside and harpagide, on some smooth muscle in vitro have been studied [3].

References

Proton and sodium cation affinities of harpagide: a computational study. Colas, C., Bouchonnet, S., Rogalewicz-Gilard, F., Popot, M.A., Ohanessian, G. The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment & general theory. (2006) [Pubmed]
Vasoconstrictor activity of 8-O-acetylharpagide from Ajuga reptans. Breschi, M.C., Martinotti, E., Catalano, S., Flamini, G., Morelli, I., Pagni, A.M. J. Nat. Prod. (1992) [Pubmed]
A drug used in traditional medicine: Harpagophytum procumbens DC. IV. Effects on some isolated muscle preparations. Occhiuto, F., Circosta, C., Ragusa, S., Ficarra, P., Costa De Pasquale, R. Journal of ethnopharmacology. (1985) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share