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Chemical Compound Review

C09783     [(1S,5S,6R,7S,9R)-1,9- dihydroxy-7-methyl-5...

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Disease relevance of C09783


High impact information on C09783


Biological context of C09783


Anatomical context of C09783

  • The present study has investigated the mechanism of action of harpagoside, one of the major components of Harpagophytum procumbens, using human HepG2 hepatocarcinoma and RAW 264.7 macrophage cell lines [9].

Associations of C09783 with other chemical compounds


Gene context of C09783

  • These results suggest that the inhibition of the expression of cyclooxygenase-2 and inducible nitric oxide by harpagoside involves suppression of NF-kappaB activation, thereby inhibiting downstream inflammation and subsequent pain events [9].
  • Harpagoside, a major compound in devil's claw, did not contribute significantly to its antioxidant activity [15].
  • Moreover, a harpagoside-free extract 1 also markedly inhibited iNOS expression, indicating that other extract constituents are involved in this effect [10].

Analytical, diagnostic and therapeutic context of C09783


  1. Harpgophytum procumbens for osteoarthritis and low back pain: a systematic review. Gagnier, J.J., Chrubasik, S., Manheimer, E. BMC complementary and alternative medicine [electronic resource]. (2004) [Pubmed]
  2. Investigations on the pharmacokinetic properties of Harpagophytum extracts and their effects on eicosanoid biosynthesis in vitro and ex vivo. Loew, D., Möllerfeld, J., Schrödter, A., Puttkammer, S., Kaszkin, M. Clin. Pharmacol. Ther. (2001) [Pubmed]
  3. New and known iridoid- and phenylethanoid glycosides from Harpagophytum procumbens and their in vitro inhibition of human leukocyte elastase. Boje, K., Lechtenberg, M., Nahrstedt, A. Planta Med. (2003) [Pubmed]
  4. Effects of some iridoids from plant origin on arachidonic acid metabolism in cellular systems. Bermejo Benito, P., Díaz Lanza, A.M., Silván Sen, A.M., De Santos Galindez, J., Fernandez Matellano, L., Sanz Gómez, A., Abad Martínez, M.J. Planta Med. (2000) [Pubmed]
  5. Reverse-Phase High Pressure Liquid Chromatographic Analysis of Harpagoside, Scorodioside and Verbascoside from Scrophularia scorodonia: Quantitative Determination of Harpagoside. Díaz, A., Fernández, L., Ollivier, E., Martín, T., Villaescusa, L., Balansard, G. Planta Med. (1998) [Pubmed]
  6. Anti-inflammatory and analgesic effects of an aqueous extract of Harpagophytum procumbens. Lanhers, M.C., Fleurentin, J., Mortier, F., Vinche, A., Younos, C. Planta Med. (1992) [Pubmed]
  7. Seasonal variations in the harpagoside content of Scrophularia scorodonia L. De Santos Galíndez, J., Matellano, L.F., Lanza, A.M., Castillo, L.V. Z. Naturforsch., C, J. Biosci. (2000) [Pubmed]
  8. High anti-inflammatory activity of harpagoside-enriched extracts obtained from solvent-modified super- and subcritical carbon dioxide extractions of the roots of Harpagophytum procumbens. Günther, M., Laufer, S., Schmidt, P.C. Phytochemical analysis : PCA. (2006) [Pubmed]
  9. Harpagoside suppresses lipopolysaccharide-induced iNOS and COX-2 expression through inhibition of NF-kappaB activation. Huang, T.H., Tran, V.H., Duke, R.K., Tan, S., Chrubasik, S., Roufogalis, B.D., Duke, C.C. Journal of ethnopharmacology. (2006) [Pubmed]
  10. Downregulation of iNOS expression in rat mesangial cells by special extracts of Harpagophytum procumbens derives from harpagoside-dependent and independent effects. Kaszkin, M., Beck, K.F., Koch, E., Erdelmeier, C., Kusch, S., Pfeilschifter, J., Loew, D. Phytomedicine (2004) [Pubmed]
  11. Rapid measurement and evaluation of the effect of drying conditions on harpagoside content in Harpagophytum procumbens (devil's claw) root. Joubert, E., Manley, M., Gray, B.R., Schulz, H. J. Agric. Food Chem. (2005) [Pubmed]
  12. Herbal medicine for low back pain: a Cochrane review. Gagnier, J.J., van Tulder, M.W., Berman, B., Bombardier, C. Spine (2007) [Pubmed]
  13. Physicochemical properties of harpagoside and its in vitro release from Harpagophytum procumbens extract tablets. Chrubasik, S., Sporer, F., Dillmann-Marschner, R., Friedmann, A., Wink, M. Phytomedicine (2000) [Pubmed]
  14. De novo regeneration of Scrophularia yoshimurae Yamazaki (Scrophulariaceae) and quantitative analysis of harpagoside, an iridoid glucoside, formed in aerial and underground parts of in vitro propagated and wild plants by HPLC. Sagare, A.P., Kuo, C.L., Chueh, F.S., Tsay, H.S. Biol. Pharm. Bull. (2001) [Pubmed]
  15. Screening pharmaceutical preparations containing extracts of turmeric rhizome, artichoke leaf, devil's claw root and garlic or salmon oil for antioxidant capacity. Betancor-Fernández, A., Pérez-Gálvez, A., Sies, H., Stahl, W. J. Pharm. Pharmacol. (2003) [Pubmed]
  16. Quality control of Harpagophytum procumbens and its related phytopharmaceutical products by means of NIR-FT-Raman spectroscopy. Baranska, M., Schulz, H., Siuda, R., Strehle, M.A., Rösch, P., Popp, J., Joubert, E., Manley, M. Biopolymers (2005) [Pubmed]
  17. A drug used in traditional medicine: Harpagophytum procumbens DC. III. Effects on hyperkinetic ventricular arrhythmias by reperfusion. Costa De Pasquale, R., Busa, G., Circosta, C., Iauk, L., Ragusa, S., Ficarra, P., Occhiuto, F. Journal of ethnopharmacology. (1985) [Pubmed]
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