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MeSH Review


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Disease relevance of Harpagophytum


High impact information on Harpagophytum

  • PURPOSE: Harpagophytum extract and its marker substance harpagoside were shown to exert anti- inflammatory effects by interacting with the eicosanoid biosynthesis [2].
  • Furthermore, in 3 independent studies with different numbers of human male volunteers, a Harpagophytum extract was administered orally and tested in whole blood samples for Cys-LT and thromboxane B2 (TXB2) biosynthesis and for the determination of pharmacokinetic parameters of harpagoside [2].
  • In addition, pharmacokinetic parameters of Harpagophytum extracts were investigated in vivo.Methods And Subjects: Different fractions of Harpagophytum extracts were tested in vitro in human whole blood samples for effects on basal and ionophore A23187-stimulated cysteinyl-leukotriene (Cys-LT) and thromboxane synthesis [2].
  • LC-DAD-MS/SPE-NMR hyphenation. A tool for the analysis of pharmaceutically used plant extracts: identification of isobaric iridoid glycoside regioisomers from Harpagophytum procumbens [3].
  • In this presentation, an existing method for the determination of the iridoid glycoside harpagoside in Harpagophytum procumbens (Devil's Claw) was successfully transferred from a conventional particle-based C18 silica column to a monolithic silica column [4].

Anatomical context of Harpagophytum


Associations of Harpagophytum with chemical compounds


Gene context of Harpagophytum


  1. Efficacy and tolerance of Harpagophytum procumbens versus diacerhein in treatment of osteoarthritis. Chantre, P., Cappelaere, A., Leblan, D., Guedon, D., Vandermander, J., Fournie, B. Phytomedicine (2000) [Pubmed]
  2. Investigations on the pharmacokinetic properties of Harpagophytum extracts and their effects on eicosanoid biosynthesis in vitro and ex vivo. Loew, D., Möllerfeld, J., Schrödter, A., Puttkammer, S., Kaszkin, M. Clin. Pharmacol. Ther. (2001) [Pubmed]
  3. LC-DAD-MS/SPE-NMR hyphenation. A tool for the analysis of pharmaceutically used plant extracts: identification of isobaric iridoid glycoside regioisomers from Harpagophytum procumbens. Seger, C., Godejohann, M., Tseng, L.H., Spraul, M., Girtler, A., Sturm, S., Stuppner, H. Anal. Chem. (2005) [Pubmed]
  4. Fast HPLC for quality control of Harpagophytum procumbens by using a monolithic silica column: method transfer from conventional particle-based silica column. Schmidt, A.H. Journal of chromatography. A. (2005) [Pubmed]
  5. Harpagoside suppresses lipopolysaccharide-induced iNOS and COX-2 expression through inhibition of NF-kappaB activation. Huang, T.H., Tran, V.H., Duke, R.K., Tan, S., Chrubasik, S., Roufogalis, B.D., Duke, C.C. Journal of ethnopharmacology. (2006) [Pubmed]
  6. A drug used in traditional medicine: Harpagophytum procumbens DC. IV. Effects on some isolated muscle preparations. Occhiuto, F., Circosta, C., Ragusa, S., Ficarra, P., Costa De Pasquale, R. Journal of ethnopharmacology. (1985) [Pubmed]
  7. Inhibition of TNF-alpha synthesis in LPS-stimulated primary human monocytes by Harpagophytum extract SteiHap 69. Fiebich, B.L., Heinrich, M., Hiller, K.O., Kammerer, N. Phytomedicine (2001) [Pubmed]
  8. In vitro antiplasmodial activity of abietane and totarane diterpenes isolated from Harpagophytum procumbens (devil's claw). Clarkson, C., Campbell, W.E., Smith, P. Planta Med. (2003) [Pubmed]
  9. Anticonvulsant activity of Harpagophytum procumbens DC [Pedaliaceae] secondary root aqueous extract in mice. Mahomed, I.M., Ojewole, J.A. Brain Res. Bull. (2006) [Pubmed]
  10. Hydrophilic solutes in modified carbon dioxide extraction-prediction of the extractability using molecular dynamic simulation. Günther, M., Maus, M., Wagner, K.G., Schmidt, P.C. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. (2005) [Pubmed]
  11. Comparison between HPLC and HPTLC-densitometry for the determination of harpagoside from Harpagophytum procumbens CO(2)-extracts. Günther, M., Schmidt, P.C. Journal of pharmaceutical and biomedical analysis. (2005) [Pubmed]
  12. Harpagophytum procumbens in the treatment of knee and hip osteoarthritis. Four-month results of a prospective, multicenter, double-blind trial versus diacerhein. Leblan, D., Chantre, P., Fournié, B. Joint, bone, spine : revue du rhumatisme. (2000) [Pubmed]
  13. Inhibitory effects of the extracts of Sutherlandia frutescens (L.) R. Br. and Harpagophytum procumbens DC. on phorbol ester-induced COX-2 expression in mouse skin: AP-1 and CREB as potential upstream targets. Kundu, J.K., Mossanda, K.S., Na, H.K., Surh, Y.J. Cancer Lett. (2005) [Pubmed]
  14. Harpagophytum procumbens suppresses lipopolysaccharide-stimulated expressions of cyclooxygenase-2 and inducible nitric oxide synthase in fibroblast cell line L929. Jang, M.H., Lim, S., Han, S.M., Park, H.J., Shin, I., Kim, J.W., Kim, N.J., Lee, J.S., Kim, K.A., Kim, C.J. J. Pharmacol. Sci. (2003) [Pubmed]
  15. New and known iridoid- and phenylethanoid glycosides from Harpagophytum procumbens and their in vitro inhibition of human leukocyte elastase. Boje, K., Lechtenberg, M., Nahrstedt, A. Planta Med. (2003) [Pubmed]
  16. Addendum to the ESCOP monograph on Harpagophytum procumbens. Chrubasik, S. Phytomedicine (2004) [Pubmed]
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