Disease relevance of SODIUM

• PATIENTS: 7 patients with cirrhosis and refractory ascites had metabolic studies done while receiving a 22 mmol/d sodium, 1 L/d fluid diet [1].
• Sodium ion-dependent amino acid transport in membrane vesicles of Bacillus stearothermophilus [2].
• Sodium ion-dependent hydrogen production in Acidaminococcus fermentans [3].
• Sodium ion/hydrogen ion exchange inhibition: a new pharmacologic approach to myocardial ischemia and reperfusion injury [4].
• Sodium ion concentrations below 140 mM correlated with a precipitous decline in specific yields of pertussis toxin, an otherwise growth-associated product [5].

Psychiatry related information on SODIUM

• The influence of several parameters such as the reaction time, the amount of derivatization reagents, or the system design has been studied some amphetamines as model compounds and three derivatization reagents: sodium 1, 2-naphthoquinone-4-sulfonate, o-phthaldialdehyde, and 9-fluorenylmethyl chloroformate [6].

High impact information on SODIUM

• Sodium ion (Na+) channels, which initiate the action potential in electrically excitable cells, are the molecular targets of local anesthetic drugs [7].
• The stabilization of canonic or rare forms of the DNA bases by water molecules and metal cations has been predicted by calculating the optimal configuration of charges (using differential product/transition state stabilization approach) followed by calculations of the interactions between the base pair and a water/sodium cation [8].
• We examined the speed of onset of intranasal nedocromil sodium (1%) for relief of symptoms due to ragweed allergic rhinitis [9].
• Sodium ion uptake into isolated plasma membrane vesicles: indirect effects of other ions [10].
• Sodium ion mediated regulation of Na/K-ATPase gene expression in vascular smooth muscle cells [11].

Chemical compound and disease context of SODIUM

• During a preliminary survey on xerophthalmia in North Sumatra, Indonesia, a total of 1754 children of 0-6 years of age were examined clinically as well as with a vital staining technique, using Rose-Bengal 1%-Fluorescein sodium 1% eyedrops [12].
• Sodium ion pumps and hydrogen production in glutamate fermenting anaerobic bacteria [13].

Biological context of SODIUM

• Sodium ion-substrate symport in a marine bacterium [14].
• Sodium ion promotes the low-affinity receptor conformation and increases total low-affinity binding sites [15].
• Safety parameters evaluated included changes in serum hemoglobin, hematocrit, and sodium 1 and 24 hours after resection [16].
• Potassium and sodium cation permeabilities of skeletal sarcoplasmic reticulum vesicles were characterized by means of 3H-choline, 22Na+ and 86Rb+ isotope efflux and membrane potential measurements [17].
• Eptazocine caused a concentration-dependent inhibition against the [3H]-naloxone [( 3H]-NLX) specific binding to rat brain synaptic membrane in the absence of sodium cation and GTP (IC50; 7.83 +/- 1.57 microM) [18].

Anatomical context of SODIUM

• Sodium ion (Na) influx through cardiac Na channels triggers the action potential in cells of the working myocardium and the specialized conduction system [19].
• Sodium ion (Na+) transport, a principal function of the gallbladder epithelium, was studied by measuring the flux of 22Na across isolated human gallbladder mucosa maintained in a modified 'Ussing' flux chamber [20].
• Sodium ion influx in proliferating lymphocytes: an early component of the mitogenic signal [21].
• Overall, these findings provide compelling support for the primacy of the amiloride-sensitive taste transduction mechanism and its associated neural pathway in the recognition of the sodium cation [22].
• Sodium ion distribution in the vitreous body [23].

Associations of SODIUM with other chemical compounds

• A multicenter trial of nedocromil sodium, 1% nasal solution, compared with cromolyn sodium and placebo in ragweed seasonal allergic rhinitis [24].
• The aim of this work was to estimate the proton and sodium cation affinities of harpagide (Har), an iridoid glycoside responsible for the antiinflammatory properties of the medicinal plant Harpagophytum [25].
• Interneuronal correlation coefficients and factor analysis indicated that both the sodium cation and glutamic anion contributed to the activity elicited by MSG [26].
• CONCLUSIONS: The results confirmed that oral administration of dantrolene sodium, 1 h before exercise, had a statistically significant effect on reducing the difference between pre- and post exercise plasma CK levels compared with a placebo in the same animals, and preventing clinical ER in susceptible individuals [27].
• The 50% inhibitory concentration was 0.04 microM for traxanox sodium, 1 microM for DSCG and 660 microM for theophylline [28].
• The sodium cation coordinates either one of the naphthalene rings (1) or the diimine part of the dpp-BIAN ligand (2-5) [29].

Gene context of SODIUM

• Sodium ion binding to parvalbumin studied by 23Na NMR: a reply [30].
• The importance of the PNP-crown related effects for the regio- and stereocontrol of the substitution of chlorine atoms in the N(3)P(3) ring is discussed in terms of supramolecular sodium cation-assisted interactions between the ring oxy substituent(s) and incoming oxyanions [31].
• Sodium ion stimulates the release of atrial natriuretic polypeptides (ANP) from rat atria [32].
• Sodium ion concentrations in uterine flushings from "implanting" and "delayed implanting" mice [33].
• Sodium ion stimulated [3H]YM-09151-2 binding to D2 receptor in infected Sf9 cell membranes [34].

Analytical, diagnostic and therapeutic context of SODIUM

• Sodium ion levels, as measured by flame photometry, were also 2- to 4.5-fold higher in transformed than normal or density-inhibited cells [35].
• Sodium ion binding to serum protein thus contributes only minimally to differences in sodium measurements observed between the direct (undiluted) ion-selective electrode and flame-photometric methods [36].
• Coordination of sodium cation to an oxygen function and olefinic double bond to form molecular adduct ion in fast atom bombardment mass spectrometry [37].
• Sodium ion selective field effect transistors (ISFETs) were evaluated for their performance in measurement of sodium ions in whole blood for 'near patient' analysis in operating theatres and intensive care units [38].
• Variables evaluated included the duration of operation, catheterization and hospital stay, and changes in blood levels of haemoglobin, haematocrit and sodium 1 h after the operation [39].

References