Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Paradol 1-(4-hydroxy-3-methoxy- phenyl)decan-3-one

Synonyms: SureCN971599, CCRIS 8519, CHEMBL2071440, CS-0873, MEGxp0_001218, ...

Keum, Y.S. et al., Oloke, J.K. et al., Bode, A.M. et al., Lee, E. et al.

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Disease relevance of C10482

In the present study, we found that [6]-paradol and other structurally related derivatives, [10]-paradol, [3]-dehydroparadol, [6]-dehydroparadol, and [10]-dehydroparadol, with the exception of [3]-paradol induce apoptosis in an oral squamous carcinoma cell line, KB, in a dose-dependent manner [1].
(3)- Paradol was more active than the other homologues with a minimum inhibitory concentration (MIC) of 1 mg/ml when tested against Proteus vulgaris, Pseudomonas aeruginosa, Staphylococcus aureus and Botryodiplodia theobromae [2].

High impact information on C10482

The purpose of this study was to investigate the effect of two structurally related compounds of the ginger family, [6]-gingerol and [6]-paradol, on EGF-induced cell transformation and AP-1 activation [3].
Induction of apoptosis and caspase-3 activation by chemopreventive [6]-paradol and structurally related compounds in KB cells [1].
In the present study, [6]-gingerol and [6]-paradol were found to exert inhibitory effects on the viability and DNA synthesis of human promyelocytic leukemia (HL-60) cells [4].

References

Induction of apoptosis and caspase-3 activation by chemopreventive [6]-paradol and structurally related compounds in KB cells. Keum, Y.S., Kim, J., Lee, K.H., Park, K.K., Surh, Y.J., Lee, J.M., Lee, S.S., Yoon, J.H., Joo, S.Y., Cha, I.H., Yook, J.I. Cancer Lett. (2002) [Pubmed]
Antimicrobial effectiveness of six paradols. 1: A structure-activity relationship study. Oloke, J.K., Kolawole, D.O., Erhun, W.O. Journal of ethnopharmacology. (1989) [Pubmed]
Inhibition of epidermal growth factor-induced cell transformation and activator protein 1 activation by [6]-gingerol. Bode, A.M., Ma, W.Y., Surh, Y.J., Dong, Z. Cancer Res. (2001) [Pubmed]
Induction of apoptosis in HL-60 cells by pungent vanilloids, [6]-gingerol and [6]-paradol. Lee, E., Surh, Y.J. Cancer Lett. (1998) [Pubmed]

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