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Chemical Compound Review

gingerol     (5S)-5-hydroxy-1-(4-hydroxy- 3-methoxy...

Synonyms: SureCN32102, CHEMBL402978, AG-E-68664, BSPBio_001347, KBioGR_000067, ...
 
 
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Disease relevance of C10462

 

High impact information on C10462

 

Biological context of C10462

 

Anatomical context of C10462

 

Associations of C10462 with other chemical compounds

 

Gene context of C10462

 

Analytical, diagnostic and therapeutic context of C10462

  • The total cumulative amount of 1 excreted in the bile and 2-7 in the urine during 60 h after the oral administration of [6]-gingerol were approximately 48% and 16% of the dose, respectively [21].
  • [6]-Shogaol and [6]-gingerol, known neutral components of ginger rhizomes, were detected using gas chromatography and were found to be the most prevalent components in the fraction, occurring in quantities that resulted in a dose-dependent killing efficacy [22].
  • These results suggest that [6]-gingerol can circumvent the resistance of mutant p53- expressing cells towards chemotherapy by inducing apoptotic cell death while it exerts cytostatic effect on wild type p53- expressing cells by inducing temporal growth arrest [2].

References

  1. Pharmacokinetics of [6]-gingerol after intravenous administration in rats with acute renal or hepatic failure. Naora, K., Ding, G., Hayashibara, M., Katagiri, Y., Kano, Y., Iwamoto, K. Chem. Pharm. Bull. (1992) [Pubmed]
  2. [6]-Gingerol Induces Cell Cycle Arrest and Cell Death of Mutant p53-expressing Pancreatic Cancer Cells. Park, Y.J., Wen, J., Bang, S., Park, S.W., Song, S.Y. Yonsei Med. J. (2006) [Pubmed]
  3. Analgesic and anti-inflammatory activities of [6]-gingerol. Young, H.Y., Luo, Y.L., Cheng, H.Y., Hsieh, W.C., Liao, J.C., Peng, W.H. Journal of ethnopharmacology. (2005) [Pubmed]
  4. Inhibition of epidermal growth factor-induced cell transformation and activator protein 1 activation by [6]-gingerol. Bode, A.M., Ma, W.Y., Surh, Y.J., Dong, Z. Cancer Res. (2001) [Pubmed]
  5. [6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol ester-stimulated mouse skin. Kim, S.O., Kundu, J.K., Shin, Y.K., Park, J.H., Cho, M.H., Kim, T.Y., Surh, Y.J. Oncogene (2005) [Pubmed]
  6. [6]-Gingerol, a pungent ingredient of ginger, inhibits angiogenesis in vitro and in vivo. Kim, E.C., Min, J.K., Kim, T.Y., Lee, S.J., Yang, H.O., Han, S., Kim, Y.M., Kwon, Y.G. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  7. The active part of the [6]-gingerol molecule in mutagenesis. Nakamura, H., Yamamoto, T. Mutat. Res. (1983) [Pubmed]
  8. The stability of gingerol and shogaol in aqueous solutions. Bhattarai, S., Tran, V.H., Duke, C.C. Journal of pharmaceutical sciences. (2001) [Pubmed]
  9. Pharmacokinetics of [6]-gingerol after intravenous administration in rats. Ding, G.H., Naora, K., Hayashibara, M., Katagiri, Y., Kano, Y., Iwamoto, K. Chem. Pharm. Bull. (1991) [Pubmed]
  10. Microsomal hydroxylation and glucuronidation of [6]-gingerol. Pfeiffer, E., Heuschmid, F.F., Kranz, S., Metzler, M. J. Agric. Food Chem. (2006) [Pubmed]
  11. Induction of apoptosis in HL-60 cells by pungent vanilloids, [6]-gingerol and [6]-paradol. Lee, E., Surh, Y.J. Cancer Lett. (1998) [Pubmed]
  12. [6]-Gingerol inhibits nitric oxide synthesis in activated J774.1 mouse macrophages and prevents peroxynitrite-induced oxidation and nitration reactions. Ippoushi, K., Azuma, K., Ito, H., Horie, H., Higashio, H. Life Sci. (2003) [Pubmed]
  13. Protective role of vanilloid receptor type 1 in HCl-induced gastric mucosal lesions in rats. Horie, S., Yamamoto, H., Michael, G.J., Uchida, M., Belai, A., Watanabe, K., Priestley, J.V., Murayama, T. Scand. J. Gastroenterol. (2004) [Pubmed]
  14. Modifications of capsaicin-sensitive neurons in isolated guinea pig ileum by [6]-gingerol and lafutidine. Someya, A., Horie, S., Yamamoto, H., Murayama, T. J. Pharmacol. Sci. (2003) [Pubmed]
  15. Gingerols: a novel class of vanilloid receptor (VR1) agonists. Dedov, V.N., Tran, V.H., Duke, C.C., Connor, M., Christie, M.J., Mandadi, S., Roufogalis, B.D. Br. J. Pharmacol. (2002) [Pubmed]
  16. Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances. Surh, Y. Mutat. Res. (1999) [Pubmed]
  17. Mechanism of inhibition of peroxynitrite-induced oxidation and nitration by [6]-gingerol. Ippoushi, K., Ito, H., Horie, H., Azuma, K. Planta Med. (2005) [Pubmed]
  18. Effect of different combinations of MGK-264 or piperonyl butoxide with plant-derived molluscicides on snail reproduction. Singh, K., Singh, D.K. Arch. Environ. Contam. Toxicol. (2000) [Pubmed]
  19. Inhibitory effects of [6]-gingerol on PMA-induced COX-2 expression and activation of NF-kappaB and p38 MAPK in mouse skin. Kim, S.O., Chun, K.S., Kundu, J.K., Surh, Y.J. Biofactors (2004) [Pubmed]
  20. Inhibitory effects of [6]-gingerol, a major pungent principle of ginger, on phorbol ester-induced inflammation, epidermal ornithine decarboxylase activity and skin tumor promotion in ICR mice. Park, K.K., Chun, K.S., Lee, J.M., Lee, S.S., Surh, Y.J. Cancer Lett. (1998) [Pubmed]
  21. Metabolism of [6]-gingerol in rats. Nakazawa, T., Ohsawa, K. Life Sci. (2002) [Pubmed]
  22. Lethal efficacy of extract from Zingiber officinale (traditional Chinese medicine) or [6]-shogaol and [6]-gingerol in Anisakis larvae in vitro. Goto, C., Kasuya, S., Koga, K., Ohtomo, H., Kagei, N. Parasitol. Res. (1990) [Pubmed]
 
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