Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

NSC-76555 2,2-dichloro-N'-(2,2- dichloroethanoyl)etha...

Synonyms: AC1L3WKX, NSC76555, LS-76443, AR-1D1328, NSC 76555, ...

Higo, H. et al., Taleporos, P. et al., Binder, M.

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Disease relevance of NSC 76555

The teratogenic effects of a bis(dichloroacetyl)diamine on hamster embryos. Aortic arch anomalies and the pathogenesis of the DiGeorge syndrome [1].

High impact information on NSC 76555

Win 18,446, a bis(dichloroacetyl)diamine, is a drug that was previously shown to suppress spermatogenesis and to be an effective oral abortifacient in rats [2].
Rat embryos were either irradiated in utero with either 252Cf fission neutrons or 60Co gamma rays on day 8 of gestation or treated in utero with a bis(dichloroacetyl)diamine (a chemical teratogen) on days 9 and 10 [3].

References

The teratogenic effects of a bis(dichloroacetyl)diamine on hamster embryos. Aortic arch anomalies and the pathogenesis of the DiGeorge syndrome. Binder, M. Am. J. Pathol. (1985) [Pubmed]
Teratogenic action of bis(dichloroacetyl)diamine on rats: patterns of malformations produced in high incidence at time-limited periods of development. Taleporos, P., Salgo, M.P., Oster, G. Teratology (1978) [Pubmed]
Effects of exposing rat embryos in utero to physical or chemical teratogens are expressed later as enhanced induction of heat-shock proteins when embryonic hearts are cultured in vitro. Higo, H., Higo, K., Lee, J.Y., Hori, H., Satow, Y. Teratog., Carcinog. Mutagen. (1988) [Pubmed]

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