The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Neutrons


High impact information on Neutrons


Chemical compound and disease context of Neutrons


Biological context of Neutrons


Anatomical context of Neutrons

  • These studies revealed that neutrons repressed VL30 RNA accumulation evident within 10 min following exposure in brain, gut, thymus and spleen but not in liver, in which VL30 RNA was unaffected by radiation exposure [18].
  • RESULTS: The development of acquired cis-platinum resistance conferred collateral resistance to 62.5 MeV (p--Be+) neutrons in all five cell lines, but did not consistently decrease the photon sensitivity of these same cells [19].
  • PURPOSE: To investigate the protective effects of dimethyl sulfoxide (DMSO) on cell killing and mutagenicity at the HPRT locus in Chinese hamster ovary (CHO) cells against thermal and epithermal neutrons produced at the Kyoto University Research (KUR) reactor [20].
  • The relative biological effectiveness of neutrons at 50% reductions of testis weight, primary spermatocytes, and elongated spermatids were 2.5, 10.0 and 6.1, respectively [21].
  • The aim of this study was to investigate the responsiveness of the epithelium of the colon of the rat to electrical and pharmacological (serotonin, carbachol) stimulation concomitantly with in vivo assessment of the absorptive capacity of the colon at 1, 3, 5 and 7 days after 3.8 Gy whole-body exposure to neutrons [22].

Associations of Neutrons with chemical compounds

  • With a multiaxial retrospective analysis, the overall survival of this study group appears to be least equivalent to that reported with 6,000 photon rad alone or of neutrons, and compares favorably to that achieved with combined 6,000 photo rad plus 5-fluorouracil [23].
  • Boron neutron capture therapy (BNCT) is a form of radiation therapy mediated by the short-range (less than 10 microns) energetic alpha (4He) and lithium-7 (7Li) ionizing particles that result from the prompt disintegration by slow neutrons of the stable (nonradioactive) nucleus boron-10 (10B) [24].
  • Comment on "giant absorption cross section of ultracold neutrons in gadolinium" [25].
  • The triton fragments originating from this channel were detected in coincidence with the two neutrons [26].
  • A consequence of the native interaction between neutrons and biological samples is that the hydrogen isotopes (1)H and (2)H are most significant in dynamical and structural studies, respectively [27].

Gene context of Neutrons

  • To determine whether neutron-induced cellular transformation involves ras mutation, C3H10T1/2 cells were exposed to a single dose of 5.9 MeV neutrons [28].
  • Delayed expression of hpS2 and prolonged expression of CIP1/WAF1/SDI1 in human tumour cells irradiated with X-rays, fission neutrons or 1 GeV/nucleon Fe ions [29].
  • This indicates that radiation-induced apoptosis is mostly due to double strand breaks (DSBs) in DNA because we previously obtained almost the same RBE value of fission neutrons for the induction of crossover mutations in Drosophila melanogaster, which arise from the recombinational repair of DSBs [30].
  • Experiments were designed to examine in vivo changes in total transcription and in the expression of the c-fos gene following whole-body exposure of mice to JANUS fission-spectrum neutrons [31].
  • Radiation repair-deficient (wst/wst) and -proficient (wst/., C57BL/6 x C3H F1) mice were exposed to JANUS fission-spectrum neutrons calibrated to deliver a gut dose of 50 cGy [31].

Analytical, diagnostic and therapeutic context of Neutrons


  1. Effect of combined misonidazole and d(50)-Be neutrons on a human melanoma transplanted into nude mice. Guichard, M., Gueulette, J., Octave-Prignot, M., Wambersie, A., Malaise, E.P. Radiology. (1980) [Pubmed]
  2. ras activation in human tumors and in animal model systems. Corominas, M., Sloan, S.R., Leon, J., Kamino, H., Newcomb, E.W., Pellicer, A. Environ. Health Perspect. (1991) [Pubmed]
  3. Contributions of nuclear medicine to the therapy of malignant tumors. Feinendegen, L.E. J. Cancer Res. Clin. Oncol. (1993) [Pubmed]
  4. WR-151327 increases resistance to Klebsiella pneumoniae infection in mixed-field- and gamma-photon-irradiated mice. Ledney, G.D., Elliott, T.B., Harding, R.A., Jackson, W.E., Inal, C.E., Landauer, M.R. Int. J. Radiat. Biol. (2000) [Pubmed]
  5. Hyperthermia increases chromosome breakage and loss induced by fission neutrons in Drosophila melanogaster. Mittler, S. Mutat. Res. (1984) [Pubmed]
  6. Efficacy of brachytherapy with californium-252 neutrons versus cesium-137 photons for eradication of bulky localized cervical cancer: single-institution study. Maruyama, Y., van Nagell, J.R., Yoneda, J., Donaldson, E., Gallion, H., Higgins, R., Powell, D., Turner, C., Kryscio, R. J. Natl. Cancer Inst. (1988) [Pubmed]
  7. Rat differences in mammary tumor induction with estrogen and neutron radiation. Shellabarger, C.J., Stone, J.P., Holtzman, S. J. Natl. Cancer Inst. (1978) [Pubmed]
  8. Post-separation detection of nucleic acids and proteins by neutron activation. Snapka, R.M., Kwok, K., Bernard, J.A., Harling, O.K., Varshavsky, A. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  9. Brain tryptophan hydroxylase: purification of, production of antibodies to, and cellular and ultrastructural localization in serotonergic neurons of rat midbrain. Joh, T.H., Shikimi, T., Pickel, V.M., Reis, D.J. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  10. Intratumoral delivery of boronated epidermal growth factor for neutron capture therapy of brain tumors. Yang, W., Barth, R.F., Adams, D.M., Soloway, A.H. Cancer Res. (1997) [Pubmed]
  11. Neutron capture therapy with gadopentetate dimeglumine: experiments on tumor-bearing rats. Khokhlov, V.F., Yashkin, P.N., Silin, D.I., Djorova, E.S., Lawaczeck, R. Academic radiology. (1995) [Pubmed]
  12. The carcinogenic effect of localized fission fragment irradiation of rat lung. Batchelor, A.L., Buckley, P., Gore, D.J., Jenner, T.J., Major, I.R., Bailey, M.R. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. (1980) [Pubmed]
  13. Boron neutron capture therapy of cancer: current status and future prospects. Barth, R.F., Coderre, J.A., Vicente, M.G., Blue, T.E. Clin. Cancer Res. (2005) [Pubmed]
  14. Transformation of human epidermal keratinocytes with fission neutrons. Thraves, P.J., Varghese, S., Jung, M., Grdina, D.J., Rhim, J.S., Dritschilo, A. Carcinogenesis (1994) [Pubmed]
  15. Relative biological effectiveness (RBE) of p(26) + Be neutrons from the King Faisal Specialist Hospital and Research Centre CS-30 cyclotron measured by testis weight loss. Feola, J.M., Aissi, A., Greer, W., el-Sayed, R., Clubb, B., el-Akkad, S. Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]. (1989) [Pubmed]
  16. Effects of 252Cf neutrons, transmitted through an iron block on human lymphocyte chromosome. Tanaka, K., Hoshi, M., Sawada, S., Kamada, N. Int. J. Radiat. Biol. (1994) [Pubmed]
  17. Quantitative assessment of the contribution of clustered damage to DNA double-strand breaks induced by 60Co gamma rays and fission neutrons. Pogozelski, W.K., Xapsos, M.A., Blakely, W.F. Radiat. Res. (1999) [Pubmed]
  18. Modulation of expression of virus-like elements following exposure of mice to high- and low-LET radiations. Panozzo, J., Bertoncini, D., Miller, D., Libertin, C.R., Woloschak, G.E. Carcinogenesis (1991) [Pubmed]
  19. The differential induction of collateral resistance to 62.5 MeV (p-->Be+) neutrons and 4 MeV photons by exposure to cis-platinum. Britten, R.A., Warenius, H.M., Masters, J.R., Peacock, J.H. Int. J. Radiat. Oncol. Biol. Phys. (1993) [Pubmed]
  20. Dimethyl sulfoxide protects against thermal and epithermal neutron-induced cell death and mutagenesis of Chinese hamster ovary (CHO) cells. Kinashi, Y., Sakurai, Y., Masunaga, S., Suzuki, M., Akaboshi, M., Ono, K. Int. J. Radiat. Oncol. Biol. Phys. (2000) [Pubmed]
  21. The relative biological effectiveness of low doses of 14 MeV neutrons in steady-state murine spermatogenesis as determined by flow cytometry. Hacker-Klom, U.B., Köhnlein, W., Kronholz, H.L., Göhde, W. Radiat. Res. (2000) [Pubmed]
  22. Modified absorptive and secretory processes in the rat distal colon after neutron irradiation: in vivo and in vitro studies. François, A., Dublineau, I., Lebrun, F., Ksas, B., Griffiths, N.M. Radiat. Res. (1999) [Pubmed]
  23. Combination chemotherapy for locally advanced pancreatic cancer: equivalence to external beam irradiation and implication for future management. Smith, F.P., Stablein, D., Korsmeyer, S., Neefe, J., Chun, B.K., Woolley, P.V., Schein, P.S. J. Clin. Oncol. (1983) [Pubmed]
  24. A history of boron neutron capture therapy of brain tumours. Postulation of a brain radiation dose tolerance limit. Slatkin, D.N. Brain (1991) [Pubmed]
  25. Comment on "giant absorption cross section of ultracold neutrons in gadolinium". Felber, J., Gähler, R., Golub, R. Phys. Rev. Lett. (2000) [Pubmed]
  26. The t+n+n system and 5H. Meister, M., Chulkov, L.V., Simon, H., Aumann, T., Borge, M.J., Elze, T.W., Emling, H., Geissel, H., Hellström, M., Jonson, B., Kratz, J.V., Kulessa, R., Leifels, Y., Markenroth, K., Münzenberg, G., Nickel, F., Nilsson, T., Nyman, G., Pribora, V., Richter, A., Riisager, K., Scheidenberger, C., Schrieder, G., Tengblad, O., Zhukov, M.V. Phys. Rev. Lett. (2003) [Pubmed]
  27. Neutron scattering: good news for biotechnology. Byron, O., Gilbert, R.J. Curr. Opin. Biotechnol. (2000) [Pubmed]
  28. Neoplastic transformation of mouse C3H10T1/2 cells following exposure to neutrons does not involve mutation of ras gene as analyzed by SSCP and cycle sequencing. Freyer, G.A., Palmer, D.A., Yu, Y., Miller, R.C., Pandita, T.K. Mutat. Res. (1996) [Pubmed]
  29. Delayed expression of hpS2 and prolonged expression of CIP1/WAF1/SDI1 in human tumour cells irradiated with X-rays, fission neutrons or 1 GeV/nucleon Fe ions. Balcer-Kubiczek, E.K., Zhang, X.F., Harrison, G.H., Zhou, X.J., Vigneulle, R.M., Ove, R., McCready, W.A., Xu, J.F. Int. J. Radiat. Biol. (1999) [Pubmed]
  30. Dose and dose-rate effects of X rays and fission neutrons on lymphocyte apoptosis in p53(+/+) and p53(-/-) mice. Fujikawa, K., Hasegawa, Y., Matsuzawa, S., Fukunaga, A., Itoh, T., Kondo, S. J. Radiat. Res. (2000) [Pubmed]
  31. Differential effect of ionizing radiation on transcription in repair-deficient and repair-proficient mice. Munson, G.P., Woloschak, G.E. Cancer Res. (1990) [Pubmed]
  32. Cytosar-U (Ara-C) induced changes in mouse jejunal crypt epithelial kinetics and radiosensitivity to gamma rays and fast neutrons. Hanson, W.R., Boston, D.L. Int. J. Radiat. Oncol. Biol. Phys. (1983) [Pubmed]
  33. Treatment options for localized prostate cancer based on pretreatment serum prostate specific antigen levels. Vicini, F.A., Horwitz, E.M., Gonzalez, J., Martinez, A.A. J. Urol. (1997) [Pubmed]
  34. Comet assay to sense neutron 'fingerprint'. Gajendiran, N., Tanaka, K., Kamada, N. Mutat. Res. (2000) [Pubmed]
  35. A preliminary time-of-flight neutron diffraction study of Streptomyces rubiginosus D-xylose isomerase. Hanson, B.L., Langan, P., Katz, A.K., Li, X., Harp, J.M., Glusker, J.P., Schoenborn, B.P., Bunick, G.J. Acta Crystallogr. D Biol. Crystallogr. (2004) [Pubmed]
  36. Radioprotection of normal tissues against gamma rays and cyclotron neutrons with WR-2721: LD50 studies and 35S-WR-2721 biodistribution. Rasey, J.S., Nelson, N.J., Mahler, P., Anderson, K., Krohn, K.A., Menard, T. Radiat. Res. (1984) [Pubmed]
WikiGenes - Universities