Disease relevance of NSC59354

• A study of the teratogenic effects of Fertilysin, a bis(dichloroacetyl)diamine, on hamster embryos was undertaken for a comparison of Fertilysin-induced malformations with the DiGeorge syndrome of human patients, a rare birth defect characterized by thymic and parathyroid gland agenesis, abnormal facies, and aortic arch malformations [1].
• Tetralogy of Fallot, truncus arteriosus, abnormal myocardial architecture and anomalies of the aortic arch system induced by bis-diamine in rat fetuses [2].
• Those from bis-diamine treated embryos exhibited common arterial trunk (32%), overriding aortic valve with valvar pulmonary stenosis (40%) or infundibular atresia (4%), or ventricular septal defect (24%) [3].
• Particularly, administration of bis-diamine to chick embryos at stage 13 resulted in a high incidence of persistent truncus arteriosus (64.3%) [4].
• We studied 11 fetal rats with normal heart and diaphragmatic hernia induced by administration of bis-diamine (200 mg) on the 9th and 10th day of pregnancy [5].

Psychiatry related information on NSC59354

• Our animal data suggest that the human syndrome results from exposure in utero to agents like WIN 18,446, which damage the fetus during a critical period of organogenesis [6].

High impact information on NSC59354

• Thirty-five fetuses with a normal heart treated with fertilysin served as controls [7].
• We studied 55 fetal rats with truncus arteriosus among 300 fetuses from 40 virgin females treated with 200 mg fertilysin on the 10th day of pregnancy [7].
• The aim of this study was to analyze the relation between anomalies of the heart and aortic arch arteries in near-term rat fetuses exposed to the chemical bis-diamine [2].
• 5. CONCLUSIONS: These results suggest that bis-diamine induces cardiac anomalies by delaying the migration of neural crest cells into the heart and by disturbing the proliferation of pericardial precursor during early cardiac development [8].
• 5. However, more N-CAM immunoreactive cells were detected in the bis-diamine-treated embryos than in controls on ED 12 [8].

Biological context of NSC59354

• Thus, 60 to 100% of offspring of rats given WIN 18,446 on the tenth and 11th days of gestation died at birth or within 4 days (Taleporos et al., 78) [9].
• Thus, we suggest that bisdiamine inhibits the normal formation of the extracellular matrix, leading to reduced cell proliferation, but it does not affect matrix-cell interaction [10].
• 5. CONCLUSIONS: The ventricular disproportion in the bis-diamine-treated heart may be caused by the early myocardial differentiation delay and poor proliferation and reduced apoptosis associated with anomalous circulatory condition in the later stage [11].

Anatomical context of NSC59354

• There were 42 fetal rats with this complex among 300 fetuses treated with N,N'-bis-(dichloroacetyl)-1,8-octamethylenediamine (bis-diamine) (200 mg) on the 10th day of pregnancy [12].
• We studied the effects of bisdiamine on mesenchymal cells grown in aggregate culture isolated from the developing atrioventricular valves of the stage-36 chick embryo [10].
• Inhibition of epibranchial placode-derived ganglia in the developing rat by bisdiamine [13].
• These results indicate that administration of bisdiamine induces malformation in the great blood vessels by disturbing persistency and degeneration of aortic arch arteries and DAs [14].
• Administration of bisdiamine inhibited development of the petrosal and nodose ganglia, altered associations of the glossopharyngeal, vagus, and hypoglossal nerves, and inhibited contributions of vagal nerve fibers to the developing enteric system [13].

Associations of NSC59354 with other chemical compounds

• Cardiovascular anomalies in chick embryos produced by bis-diamine in dimethylsulfoxide [4].

Gene context of NSC59354

• Hepatocyte growth factor and cardiotrophin-1 mRNA expression was upregulated on embryonic day 12.5 and 15.5 in bis-diamine-treated hearts [11].
• Bisdiamine inhibits extracellular matrix formation and cell proliferation of atrioventricular mesenchyme from developing chick heart valves [10].

Analytical, diagnostic and therapeutic context of NSC59354

• 5. Embryos from these pregnant rats were removed 6 hr after the oral administration of bis-diamine, and were also cultured in medium only for 6, 12, 18, and 42 hr [8].
• In order to clarify cross-sectional morphology of tetralogy of Fallot in the fetus, 202 rat fetuses with tetralogy of Fallot induced by maternal administration of bis-diamine were studied using cesarean section, the whole body freezing method and by photographing cross sections of the fetal heart on a freezing microtome [15].

References