The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Bisdiamine     2,2-dichloro-N-[8-(2,2...

Synonyms: Fertilysin, Fertilysine, Bis-Diamine, Fertilysine N, ANW-44572, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of NSC59354


Psychiatry related information on NSC59354


High impact information on NSC59354

  • Thirty-five fetuses with a normal heart treated with fertilysin served as controls [7].
  • We studied 55 fetal rats with truncus arteriosus among 300 fetuses from 40 virgin females treated with 200 mg fertilysin on the 10th day of pregnancy [7].
  • The aim of this study was to analyze the relation between anomalies of the heart and aortic arch arteries in near-term rat fetuses exposed to the chemical bis-diamine [2].
  • 5. CONCLUSIONS: These results suggest that bis-diamine induces cardiac anomalies by delaying the migration of neural crest cells into the heart and by disturbing the proliferation of pericardial precursor during early cardiac development [8].
  • 5. However, more N-CAM immunoreactive cells were detected in the bis-diamine-treated embryos than in controls on ED 12 [8].

Biological context of NSC59354

  • Thus, 60 to 100% of offspring of rats given WIN 18,446 on the tenth and 11th days of gestation died at birth or within 4 days (Taleporos et al., 78) [9].
  • Thus, we suggest that bisdiamine inhibits the normal formation of the extracellular matrix, leading to reduced cell proliferation, but it does not affect matrix-cell interaction [10].
  • 5. CONCLUSIONS: The ventricular disproportion in the bis-diamine-treated heart may be caused by the early myocardial differentiation delay and poor proliferation and reduced apoptosis associated with anomalous circulatory condition in the later stage [11].

Anatomical context of NSC59354

  • There were 42 fetal rats with this complex among 300 fetuses treated with N,N'-bis-(dichloroacetyl)-1,8-octamethylenediamine (bis-diamine) (200 mg) on the 10th day of pregnancy [12].
  • We studied the effects of bisdiamine on mesenchymal cells grown in aggregate culture isolated from the developing atrioventricular valves of the stage-36 chick embryo [10].
  • Inhibition of epibranchial placode-derived ganglia in the developing rat by bisdiamine [13].
  • These results indicate that administration of bisdiamine induces malformation in the great blood vessels by disturbing persistency and degeneration of aortic arch arteries and DAs [14].
  • Administration of bisdiamine inhibited development of the petrosal and nodose ganglia, altered associations of the glossopharyngeal, vagus, and hypoglossal nerves, and inhibited contributions of vagal nerve fibers to the developing enteric system [13].

Associations of NSC59354 with other chemical compounds


Gene context of NSC59354


Analytical, diagnostic and therapeutic context of NSC59354


  1. The teratogenic effects of a bis(dichloroacetyl)diamine on hamster embryos. Aortic arch anomalies and the pathogenesis of the DiGeorge syndrome. Binder, M. Am. J. Pathol. (1985) [Pubmed]
  2. Tetralogy of Fallot, truncus arteriosus, abnormal myocardial architecture and anomalies of the aortic arch system induced by bis-diamine in rat fetuses. Kuribayashi, T., Roberts, W.C. J. Am. Coll. Cardiol. (1993) [Pubmed]
  3. Common arterial trunk and pulmonary atresia: close developmental cousins? results from a teratogen induced animal model. Jackson, M., Connell, M.G., Smith, A., Drury, J., Anderson, R.H. Cardiovasc. Res. (1995) [Pubmed]
  4. Cardiovascular anomalies in chick embryos produced by bis-diamine in dimethylsulfoxide. Okishima, T., Takamura, K., Matsuoka, Y., Ohdo, S., Hayakawa, K. Teratology (1992) [Pubmed]
  5. Hypoplasia of the lung and heart in fetal rats with diaphragmatic hernia. Momma, K., Ando, M., Mori, Y., Ito, T. Fetal. Diagn. Ther. (1992) [Pubmed]
  6. Chemically induced congenital thymic dysgenesis in the rat: a model of the DiGeorge syndrome. Oster, G., Kilburn, K.H., Siegal, F.P. Clin. Immunol. Immunopathol. (1983) [Pubmed]
  7. Fetal cardiovascular morphology of truncus arteriosus with or without truncal valve insufficiency in the rat. Momma, K., Ando, M., Takao, A., Miyagawa-Tomita, S. Circulation (1991) [Pubmed]
  8. Teratogenic effects of bis-diamine on early embryonic rat heart: an in vitro study. Nishijima, S., Nakagawa, M., Fujino, H., Hanato, T., Okamoto, N., Shimada, M. Teratology (2000) [Pubmed]
  9. Perinatal death and respiratory apparatus dysgenesis due to a bis (dichloroacetyl) diamine. Kilburn, K.H., Hess, R.A., Lesser, M., Oster, G. Teratology (1982) [Pubmed]
  10. Bisdiamine inhibits extracellular matrix formation and cell proliferation of atrioventricular mesenchyme from developing chick heart valves. Choy, M., Oltjen, S.L., Moon, A.J., Armstrong, M.T., Armstrong, P.B. Teratology (1999) [Pubmed]
  11. Teratogenic effects of bis-diamine on the developing myocardium. Okamoto, N., Nakagawa, M., Fujino, H., Nishijima, S., Hanato, T., Narita, T., Takeuchi, Y., Imanaka-Yoshida, K. Birth defects research. Part A, Clinical and molecular teratology. (2004) [Pubmed]
  12. Fetal cardiac morphology of tetralogy of Fallot with absent pulmonary valve in the rat. Momma, K., Ando, M., Takao, A. Circulation (1990) [Pubmed]
  13. Inhibition of epibranchial placode-derived ganglia in the developing rat by bisdiamine. Kuratani, S.C., Bockman, D.E. Anat. Rec. (1992) [Pubmed]
  14. Abnormal development of cardiovascular systems in rat embryos treated with bisdiamine. Tasaka, H., Takenaka, H., Okamoto, N., Onitsuka, T., Koga, Y., Hamada, M. Teratology (1991) [Pubmed]
  15. Fetal cardiovascular cross-sectional morphology of tetralogy of Fallot in rats. Momma, K., Ando, M., Takao, A., Wu, F.F. Fetal. Diagn. Ther. (1990) [Pubmed]
WikiGenes - Universities