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Gene Review

H6pd  -  hexose-6-phosphate dehydrogenase (glucose...

Mus musculus

Synonyms: AI785303, G6pd1, GDH/6PGL endoplasmic bifunctional protein, Gpd-1, Gpd1
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Disease relevance of H6pd

  • Thus polyunsaturated fat-cholesterol induced postprandial hypercholesterolemia appeared to be genetically determined by a gene located between the Gpd-1 and Ahd-1 loci, in mice [1].

High impact information on H6pd

  • Recombinant animals were screened in a hierarchical fashion with a variety of other markers, including Fv1 and the isozyme marker Gpd1 [2].
  • The mouse HL locus (Hmgcl) was localized on Chromosome (Chr) 4: Pmv-19-12.6 +/- 3.6 cM-Hmgcl-7.3 +/- 2.3 cM-Xmv-8-1.5 +/- 1.0 cM-Gpd-1 [3].
  • In this study, non-responsiveness cosegregated with the b allele at the Gpd-1 and Ahd-1 loci [1].
  • Glucose 6-phosphate dehydrogenase-1 (Gpd-1), located on the distal part of chromosome 4, showed 26% recombination frequency with azh, indicating significant linkage (P less than .001) [4].
  • In backcrosses and the F2 generation, PGD segregated as a singly autosomal gene, designated Pgd, closely linked to Gpd-1 on chromosome 4(1.7 +/- 1.1%) [5].

Associations of H6pd with chemical compounds

  • The genetic locus encoding AHD-A2 (suggested name Ahd-1) is localized on chromosome 4 and was mapped close to je (jerker) and Gpd-1 (encoding the liver and kidney isoenzyme of glucose-6-phosphate dehydrogenase) [6].


  1. Regulation of polyunsaturated fat induced postprandial hypercholesterolemia by a novel gene Phc-2. Vaithilingam, D.S., Antao, V., Kakis, G. Mol. Cell. Biochem. (1994) [Pubmed]
  2. Genetic map of the region surrounding the retrovirus restriction locus, Fv1, on mouse chromosome 4. Stoye, J.P., Kaushik, N., Jeremiah, S., Best, S. Mamm. Genome (1995) [Pubmed]
  3. 3-Hydroxy-3-methylglutaryl coenzyme A lyase (HL): cloning and characterization of a mouse liver HL cDNA and subchromosomal mapping of the human and mouse HL genes. Wang, S., Nadeau, J.H., Duncan, A., Robert, M.F., Fontaine, G., Schappert, K., Johnson, K.R., Zietkiewicz, E., Hruz, P., Miziorko, H. Mamm. Genome (1993) [Pubmed]
  4. Mapping of the azh locus to mouse chromosome 4. Meistrich, M.L., Trostle-Weige, P.K., Womack, J.E. J. Hered. (1992) [Pubmed]
  5. 6-Phosphogluconate dehydrogenase (PGD) genetics in the mouse: linkage with metabolically related enzyme loci. Chapman, V.M. Biochem. Genet. (1975) [Pubmed]
  6. Genetics and ontogeny of aldehyde dehydrogenase isozymes in the mouse: localization of Ahd-1 encoding the mitochondrial isozyme on chromosome 4. Holmes, R.S. Biochem. Genet. (1978) [Pubmed]
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