Disease relevance of Pgd

• Relationships between UMPK and PGD activities and deletions of chromosome 1p in colorectal cancers [1].

High impact information on Pgd

• GPI (EC 5.3.1.9) and PGD (EC 1.1.1.44) phenotypes were determined by agarose gel electrophoresis of isozymes [2].
• The maximum five-point lod score was the same to four decimal places irrespective of the order of ENO1 and PGD [2].
• Transcriptional regulation of mouse 6-phosphogluconate dehydrogenase by ADD1/SREBP1c [3].
• It was found that a clear relationship exists between activity and the number of chromosome 1p for PGD but not for UMPK, both on primary tumors (PTs) and on tumors grafted into nude mice (GTs) [1].
• Functional dizygosity of ENO1, PGD, and PGM1 in CHO cells, as determined by the isolation of diploid heterozygous electrophoretic shift mutants following UV and EMS exposure, confirmed their location outside the Z2 deletion and indicated that the deletion did not result in the inactivation of adjacent loci [4].

Biological context of Pgd

• In backcrosses and the F2 generation, PGD segregated as a singly autosomal gene, designated Pgd, closely linked to Gpd-1 on chromosome 4(1.7 +/- 1.1%) [5].
• 6-Phosphogluconate dehydrogenase (PGD) genetics in the mouse: linkage with metabolically related enzyme loci [5].
• However, several autosomal synteny groups 10 to 20 cM apart, including the Pgd, Eno-1, Pgm-1 group on human chromosome arm 1p, are conserved in mice and man [6].

References