The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

Fv1  -  Friend virus susceptibility 1

Mus musculus

Synonyms: Friend virus susceptibility protein 1, Fv-1, Rv-1, Rv1
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Fv1

 

High impact information on Fv1

  • Operating under a Gag order: a block against incoming virus by the Fv1 gene [4].
  • Mapping experiments using BXD recombinant inbred mice as well as other inbred strains indicate that a single strain-specific modifier (Ssm-1) linked to, but distinct from, Fv-1 is responsible for the strain effect [5].
  • Induction of the erythroid colonies is under genetic control at the Fv1 susceptibility locus, but not at the Fv2 susceptibility locus [6].
  • Fv-1 regulation of lymphoma development and of thymic ecotropic and xenotropic MuLV expression in mice of the AKR/J x RF/J cross [7].
  • The RF gene governing the coordinate suppression of these three phenotypes has been mapped to the Fv-1 locus [7].
 

Chemical compound and disease context of Fv1

 

Biological context of Fv1

  • Efficiency of transfection for all DNAs was better in the NIH-3T3 cells than in C57BL/6 or SV-A31 cells; and an [N-tropic MuLV]SC-1 cell DNA preparation was slightly more infectious than a [B-tropic MuLV]SC-1 cell DNA preparation in all three cell cultures, regardless of their Fv-1 genotypes [2].
  • Transfection of Fv-1 permissive and restrictive mouse cells with integrated DNA of murine leukemia viruses [2].
  • A variety of amino acid changes affecting Fv1 tropism were identified, at CA positions 82, 92 to 95, 105, 114, and 117, and they all were mapped to the apparent exterior of virion-associated CA [10].
  • Retroviral restriction factors Fv1 and TRIM5alpha act independently and can compete for incoming virus before reverse transcription [11].
  • We introduced various amino acid substitutions at these two sites in the N-tropic AKV MLV capsid gene, and typed resulting viruses for host range on cells carrying all five Fv1 alleles as well as on cells from additional wild mouse species with Fv1-like differences in virus susceptibility [12].
 

Anatomical context of Fv1

 

Associations of Fv1 with chemical compounds

  • Recently, we demonstrated that the Friend virus susceptibility locus, Fv2, which is required for the expansion of infected cells, encodes a naturally occurring, N-terminally truncated form of the Stk receptor tyrosine kinase (Sf-Stk) [17].
  • RNA prepared by phenol-chloroform extraction of mouse tissues, including embryos and livers of weanling mice, transferred Fv-1 locus-specific resistance into DEAE-dextran-treated SC-1 cells [18].
  • However levels of closed circular (form I) viral DNA separated on ethidium bromide-cesium chloride gradients were found to be decreased in Fv-1 resistant cells [19].
  • It was found that the major viral DNA species made in Fv-1 permissive or resistant cells was sedimenting at 20S on neutral sucrose gradient [19].
  • Analysis of the Fv1 alleles involved in the susceptibility of mice to lactate dehydrogenase-elevating virus-induced polioencephalomyelitis [20].
 

Regulatory relationships of Fv1

  • The results suggest that XenCSA expression is affected by more than one gene but that the predominant influence is exerted by a single semidominant gene apparently located on chromosome 4 at or in close proximity to the Fv-1 locus [21].
  • The Fv-1 gene of the mouse and its control of murine leukemia virus replication [22].
 

Other interactions of Fv1

  • No recombination event between Anf and the Fv-1 locus was evident in any of the 34 strains tested [23].
  • Recombinant animals were screened in a hierarchical fashion with a variety of other markers, including Fv1 and the isozyme marker Gpd1 [1].
  • By combining backcross and recombinant inbred strain data, we estimated that Xmv9 and Nppa must lie within 0.6 cM of one another and Fv1 [1].
  • Mapping of the mouse atrial natriuretic factor gene. Evidence for tight linkage to the Fv-1 locus [23].
  • In these congenic strain analyses, the Nppa and Fv1 loci, in addition to genes within about 1 cM of these loci, have been excluded as candidates for the Pctr2 locus [24].
 

Analytical, diagnostic and therapeutic context of Fv1

  • Sequence analysis of a candidate gene on distal chromosome 4, Fv1, provided support that this gene may be associated with the control of serum gp70 levels in both New Zealand Black and New Zealand White mice [25].
  • Analysis of genetic crosses of Mus spretus and Mus musculus praetextus demonstrated that the nonrestrictive phenotype is controlled by a novel allele at the Fv-1 locus, designated Fv-10 [26].
  • A standardized bioassay for transfer of Fv-1 gene-specific resistance to N-tropic and B-tropic murine retroviruses was developed using X plaque reduction in SC-1 (Fv-1-) cells inoculated with virus [18].
  • PCR primers, chosen to include most of the coding region of Fv1 for both the n and b alleles, were used to amplify sequences from animals of the genus Mus, which were then sequenced [27].
  • A new gene, SRV, the dominant allele of which occurs in mice of strain C57BL, independently modifies the slope ("hitness") and level of sensitivity of the titration curves obtained when one subclass of B-tropic murine leukemia viruses is propagated on mouse embryo cells of nonpermissive Fv-1 genotypes [28].

References

  1. Genetic map of the region surrounding the retrovirus restriction locus, Fv1, on mouse chromosome 4. Stoye, J.P., Kaushik, N., Jeremiah, S., Best, S. Mamm. Genome (1995) [Pubmed]
  2. Transfection of Fv-1 permissive and restrictive mouse cells with integrated DNA of murine leukemia viruses. Hsu, I.C., Yang, W.K., Tennant, R.W., Brown, A. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  3. Positional cloning of the mouse retrovirus restriction gene Fv1. Best, S., Le Tissier, P., Towers, G., Stoye, J.P. Nature (1996) [Pubmed]
  4. Operating under a Gag order: a block against incoming virus by the Fv1 gene. Goff, S.P. Cell (1996) [Pubmed]
  5. A strain-specific modifier on mouse chromosome 4 controls the methylation of independent transgene loci. Engler, P., Haasch, D., Pinkert, C.A., Doglio, L., Glymour, M., Brinster, R., Storb, U. Cell (1991) [Pubmed]
  6. Harvey and Kirsten sarcoma viruses promote the growth and differentiation of erythroid precursor cells in vitro. Hankins, W.D., Scolnick, E.M. Cell (1981) [Pubmed]
  7. Fv-1 regulation of lymphoma development and of thymic ecotropic and xenotropic MuLV expression in mice of the AKR/J x RF/J cross. Mayer, A., Duran-Reynals, M.L., Lilly, F. Cell (1978) [Pubmed]
  8. Intrinsic immunity: a front-line defense against viral attack. Bieniasz, P.D. Nat. Immunol. (2004) [Pubmed]
  9. Inherited resistance to N- and B-tropic murine leukemia viruses in vitro: effect of dexamethasone on the expression of the Fv-1 gene in the congenic strains SIM and SIM.R. Blackstein, M.E., Kochman, M.A. Virology (1976) [Pubmed]
  10. Retroviral capsid determinants of Fv1 NB and NR tropism. Stevens, A., Bock, M., Ellis, S., LeTissier, P., Bishop, K.N., Yap, M.W., Taylor, W., Stoye, J.P. J. Virol. (2004) [Pubmed]
  11. Retroviral restriction factors Fv1 and TRIM5alpha act independently and can compete for incoming virus before reverse transcription. Passerini, L.D., Keckesova, Z., Towers, G.J. J. Virol. (2006) [Pubmed]
  12. Single amino acid changes in the murine leukemia virus capsid protein gene define the target of Fv1 resistance. Kozak, C.A., Chakraborti, A. Virology (1996) [Pubmed]
  13. Intracellular localisation of Fv1. Yap, M.W., Stoye, J.P. Virology (2003) [Pubmed]
  14. A conserved mechanism of retrovirus restriction in mammals. Towers, G., Bock, M., Martin, S., Takeuchi, Y., Stoye, J.P., Danos, O. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  15. Use of a transient assay for studying the genetic determinants of Fv1 restriction. Bock, M., Bishop, K.N., Towers, G., Stoye, J.P. J. Virol. (2000) [Pubmed]
  16. Analysis of Fv-1 restriction in two murine embryonal carcinoma cell lines and a series of differentiated derivatives. Heitman, C.K., Innes, C.L., Jetten, A.M., Boone, L.R. J. Gen. Virol. (1991) [Pubmed]
  17. Sf-Stk kinase activity and the Grb2 binding site are required for Epo-independent growth of primary erythroblasts infected with Friend virus. Finkelstein, L.D., Ney, P.A., Liu, Q.P., Paulson, R.F., Correll, P.H. Oncogene (2002) [Pubmed]
  18. Transfer of Fv-1 locus-specific resistance to murine N-tropic and B-tropic retroviruses by cytoplasmic RNA. Yang, W.K., Tennant, R.W., Rascati, R.J., Otten, J.A., Schluter, B., Kiggans, J.O., Myer, F.E., Brown, A. J. Virol. (1978) [Pubmed]
  19. Effect of Fv-1 gene product on synthesis of linear and supercoiled viral DNA in cells infected with murine leukemia virus. Jolicoeur, P., Rassart, E. J. Virol. (1980) [Pubmed]
  20. Analysis of the Fv1 alleles involved in the susceptibility of mice to lactate dehydrogenase-elevating virus-induced polioencephalomyelitis. Monteyne, P., Coulie, P.G., Coutelier, J.P. J. Neurovirol. (2000) [Pubmed]
  21. Expression of xenotropic murine leukemia viruses as cell-surface gp70 in genetic crosses between strains DBA/2 and C57BL/6. Morse, H.C., Chused, T.M., Hartley, J.W., Mathieson, B.J., Sharrow, S.O., Taylor, B.A. J. Exp. Med. (1979) [Pubmed]
  22. The Fv-1 gene of the mouse and its control of murine leukemia virus replication. Jolicoeur, P. Curr. Top. Microbiol. Immunol. (1979) [Pubmed]
  23. Mapping of the mouse atrial natriuretic factor gene. Evidence for tight linkage to the Fv-1 locus. Mullins, J.J., Zeng, Q., Gross, K.W. Hypertension (1987) [Pubmed]
  24. The plasmacytoma resistance gene, Pctr2, delays the onset of tumorigenesis and resides in the telomeric region of chromosome 4. Mock, B.A., Hartley, J., Le Tissier, P., Wax, J.S., Potter, M. Blood (1997) [Pubmed]
  25. A novel locus regulates both retroviral glycoprotein 70 and anti-glycoprotein 70 antibody production in New Zealand mice when crossed with BALB/c. Rigby, R.J., Rozzo, S.J., Gill, H., Fernandez-Hart, T., Morley, B.J., Izui, S., Kotzin, B.L., Vyse, T.J. J. Immunol. (2004) [Pubmed]
  26. Analysis of wild-derived mice for Fv-1 and Fv-2 murine leukemia virus restriction loci: a novel wild mouse Fv-1 allele responsible for lack of host range restriction. Kozak, C.A. J. Virol. (1985) [Pubmed]
  27. Molecular phylogeny of Fv1. Qi, C.F., Bonhomme, F., Buckler-White, A., Buckler, C., Orth, A., Lander, M.R., Chattopadhyay, S.K., Morse, H.C. Mamm. Genome (1998) [Pubmed]
  28. New gene locus modifying susceptibility to certain B-tropic murine leukemia viruses. Declève, A., Niwa, O., Kojola, J., Kaplan, H.S. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
 
WikiGenes - Universities