Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

DNAJB6 - DnaJ (Hsp40) homolog, subfamily B, member 6

Homo sapiens

Synonyms: DJ4, DnaJ, DnaJ homolog subfamily B member 6, HHDJ1, HSJ-2, ...

Chuang, J.Z. et al., Hanai, R. et al., Pei, L., Meccariello, R. et al.

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Disease relevance of DNAJB6

Characterization of a brain-enriched chaperone, MRJ, that inhibits Huntingtin aggregation and toxicity independently [1].

High impact information on DNAJB6

In an in vitro cell model of HD, overexpressed MRJ effectively suppressed polyglutamine-dependent protein aggregation, caspase activity, and cellular toxicity [1].
Tissue distribution studies showed that MRJ is highly enriched in the central nervous system [1].
Northern blot analysis showed that testis contains higher levels of HSJ2 mRNA than other tissues examined, and the expression pattern of HSJ2 mRNA in postnatal rat testis is similar to PTTG [2].
MSJ-1 levels did not change in brain and spinal cord [3].
Nucleotide sequencing showed that the gene product HSJ2 was longer than previously reported, extending its homology to other human DnaJ paralogues, and that the two cDNAs encoded two proteins as a result of alternative splicing [4].

References

Characterization of a brain-enriched chaperone, MRJ, that inhibits Huntingtin aggregation and toxicity independently. Chuang, J.Z., Zhou, H., Zhu, M., Li, S.H., Li, X.J., Sung, C.H. J. Biol. Chem. (2002) [Pubmed]
Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells. Pei, L. J. Biol. Chem. (1999) [Pubmed]
Detection of msj-1 gene expression in the frog, Rana esculenta testis, brain, and spinal cord. Meccariello, R., Cobellis, G., Scarpa, D., Fienga, G., Pierantoni, R., Fasano, S. Mol. Reprod. Dev. (2004) [Pubmed]
Characterization of two isoforms of a human DnaJ homologue, HSJ2. Hanai, R., Mashima, K. Mol. Biol. Rep. (2003) [Pubmed]

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dnj-24	Caenorhabditis elegans
DNAJB6	Canis lupus familiaris
dnajb6a	Danio rerio
dnajb6b	Danio rerio
DNAJB6	Gallus gallus
DNAJB6	Macaca mulatta
Dnajb6	Mus musculus
Dnajb6	Rattus norvegicus
dnajb6	Xenopus (Silurana) tropicalis

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