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Gene Review

GPC6  -  glypican 6

Homo sapiens

Synonyms: Glypican-6, UNQ369/PRO705
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High impact information on GPC6


Other interactions of GPC6


Analytical, diagnostic and therapeutic context of GPC6

  • In situ hybridization studies localize glypican-6 to mesenchymal tissues in the developing mouse embryo [2].
  • Northern blottings indicate that glypican-6 mRNA is widespread, with prominent expressions in human fetal kidney and adult ovary [2].


  1. Processing by convertases is not required for glypican-3-induced stimulation of hepatocellular carcinoma growth. Capurro, M.I., Shi, W., Sandal, S., Filmus, J. J. Biol. Chem. (2005) [Pubmed]
  2. Glypican-6, a new member of the glypican family of cell surface heparan sulfate proteoglycans. Veugelers, M., De Cat, B., Ceulemans, H., Bruystens, A.M., Coomans, C., Dürr, J., Vermeesch, J., Marynen, P., David, G. J. Biol. Chem. (1999) [Pubmed]
  3. Disruption of ERBB2IP is not associated with dystrophic epidermolysis bullosa in both father and son carrying a balanced 5;13 translocation. Stefanova, M., Zemke, K., Dimitrov, B., Has, C., Kern, J.S., Bruckner-Tuderman, L., Kutsche, K. J. Invest. Dermatol. (2005) [Pubmed]
  4. A 4-Mb BAC/PAC contig and complete genomic structure of the GPC5/GPC6 gene cluster on chromosome 13q32. Veugelers, M., De Cat, B., Delande, N., Esselens, C., Bonk, I., Vermeesch, J., Marynen, P., Fryns, J.P., David, G. Matrix Biol. (2001) [Pubmed]
  5. GPC6, a novel member of the glypican gene family, encodes a product structurally related to GPC4 and is colocalized with GPC5 on human chromosome 13. Paine-Saunders, S., Viviano, B.L., Saunders, S. Genomics (1999) [Pubmed]
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