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Gene Review:

GPC6 - glypican 6

Homo sapiens

Synonyms: Glypican-6, UNQ369/PRO705

Veugelers, M. et al., Veugelers, M. et al., Paine-Saunders, S. et al., Stefanova, M. et al., Capurro, M.I. et al.

Paine-Saunders, Viviano, Saunders,

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High impact information on GPC6

Six members of this family have been identified in mammals (GPC1-GPC6) [1].
Like GPC5, the gene encoding glypican-5, GPC6 maps to chromosome 13q32 [2].
GPC6, the gene encoding human glypican-6, contains nine exons [2].
GPC6 encodes glypican 6 belonging to a family of cell surface heparan sulfate proteoglycans [3].
A 4-Mb BAC/PAC contig and complete genomic structure of the GPC5/GPC6 gene cluster on chromosome 13q32 [4].

Other interactions of GPC6

We report here the identification of a human cDNA encoding a novel glypican family member, glypican-6 [5].

Analytical, diagnostic and therapeutic context of GPC6

In situ hybridization studies localize glypican-6 to mesenchymal tissues in the developing mouse embryo [2].
Northern blottings indicate that glypican-6 mRNA is widespread, with prominent expressions in human fetal kidney and adult ovary [2].

References

Processing by convertases is not required for glypican-3-induced stimulation of hepatocellular carcinoma growth. Capurro, M.I., Shi, W., Sandal, S., Filmus, J. J. Biol. Chem. (2005) [Pubmed]
Glypican-6, a new member of the glypican family of cell surface heparan sulfate proteoglycans. Veugelers, M., De Cat, B., Ceulemans, H., Bruystens, A.M., Coomans, C., Dürr, J., Vermeesch, J., Marynen, P., David, G. J. Biol. Chem. (1999) [Pubmed]
Disruption of ERBB2IP is not associated with dystrophic epidermolysis bullosa in both father and son carrying a balanced 5;13 translocation. Stefanova, M., Zemke, K., Dimitrov, B., Has, C., Kern, J.S., Bruckner-Tuderman, L., Kutsche, K. J. Invest. Dermatol. (2005) [Pubmed]
A 4-Mb BAC/PAC contig and complete genomic structure of the GPC5/GPC6 gene cluster on chromosome 13q32. Veugelers, M., De Cat, B., Delande, N., Esselens, C., Bonk, I., Vermeesch, J., Marynen, P., Fryns, J.P., David, G. Matrix Biol. (2001) [Pubmed]
GPC6, a novel member of the glypican gene family, encodes a product structurally related to GPC4 and is colocalized with GPC5 on human chromosome 13. Paine-Saunders, S., Viviano, B.L., Saunders, S. Genomics (1999) [Pubmed]

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GPC6	Canis lupus familiaris
gpc6a	Danio rerio
GPC6	Gallus gallus
Gpc6	Mus musculus
GPC6	Pan troglodytes
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gpc6	Xenopus (Silurana) tropicalis

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