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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

NUBP2  -  nucleotide binding protein 2

Homo sapiens

Synonyms: CFD1, Cytosolic Fe-S cluster assembly factor NUBP2, NBP 2, NUBP1, Nucleotide-binding protein 2
 
 
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Disease relevance of NUBP2

  • 2. To investigate the role of proteasome during neuronal differentiation, we made use of a murine neuroblastoma cell line (NBP2) that terminally differentiates into mature neurons upon elevation of the intracellular level of adenosine 3',5'-cyclic monophosphate (cAMP) [1].
 

High impact information on NUBP2

  • In addition to conserved ATP/GTP-binding motifs A (P-loop) and A', members of this family share at least two highly conserved sequence motifs, NUBP/MRP motifs alpha and beta [2].
  • Two novel mouse genes--Nubp2, mapped to the t-complex on chromosome 17, and Nubp1, mapped to chromosome 16--establish a new gene family of nucleotide-binding proteins in eukaryotes [2].
  • The level of mRNA was not detectable in murine neuroblastoma cells (NBP2) using the same alpha-amylase cDNA, PRP cDNA and PSP cDNA for hybridization [3].

References

  1. Proteasome activity is critical for the cAMP-induced differentiation of neuroblastoma cells. Nahreini, P., Andreatta, C., Prasad, K.N. Cell. Mol. Neurobiol. (2001) [Pubmed]
  2. Two novel mouse genes--Nubp2, mapped to the t-complex on chromosome 17, and Nubp1, mapped to chromosome 16--establish a new gene family of nucleotide-binding proteins in eukaryotes. Nakashima, H., Grahovac, M.J., Mazzarella, R., Fujiwara, H., Kitchen, J.R., Threat, T.A., Ko, M.S. Genomics (1999) [Pubmed]
  3. Characterization of human and rat immortalized clones parotid acinar cells with respect to specific proteins and their mRNAs, and receptor-linked adenylate cyclase. Prasad, K.N., Kumar, S., Carvalho, E., Edwards-Prasad, J., Kumar, R., La Rosa, F.G., Larsen, B.B., Ann, D. In Vitro Cell. Dev. Biol. Anim. (1995) [Pubmed]
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