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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CFD1  -  Cfd1p

Saccharomyces cerevisiae S288c

Synonyms: Cytosolic Fe-S cluster assembly factor CFD1, Cytosolic Fe-S cluster-deficient protein 1, DRE3, RIX19, Ribosomal export protein 19, ...
 
 
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High impact information on CFD1

  • In genetic screens for ribosomal export mutants, we identified CFD1, NBP35 and NAR1 as factors involved in ribosome biogenesis [1].
  • We demonstrate here that the three CIA components, Cfd1, Nbp35, and Cia1, are required for the 2-thio modification of cy-tRNAs but not of mt-tRNAs [2].
 

Anatomical context of CFD1

  • The assembly of cytosolic and nuclear iron-sulfur (Fe/S) proteins in yeast is dependent on the iron-sulfur cluster assembly and export machineries in mitochondria and three recently identified extramitochondrial proteins, the P-loop NTPases Cfd1 and Nbp35 and the hydrogenase-like Nar1 [3].
 

Other interactions of CFD1

  • In contrast, repression of NAR1, CFD1, or NBP35 fails to induce the iron regulon despite strong inhibition of cytosolic/nuclear Fe-S protein assembly [4].

References

  1. Functional link between ribosome formation and biogenesis of iron-sulfur proteins. Yarunin, A., Panse, V.G., Petfalski, E., Dez, C., Tollervey, D., Hurt, E.C. EMBO J. (2005) [Pubmed]
  2. Thio Modification of Yeast Cytosolic tRNA Is an Iron-Sulfur Protein-Dependent Pathway. Nakai, Y., Nakai, M., Lill, R., Suzuki, T., Hayashi, H. Mol. Cell. Biol. (2007) [Pubmed]
  3. The essential WD40 protein Cia1 is involved in a late step of cytosolic and nuclear iron-sulfur protein assembly. Balk, J., Aguilar Netz, D.J., Tepper, K., Pierik, A.J., Lill, R. Mol. Cell. Biol. (2005) [Pubmed]
  4. Activation of the iron regulon by the yeast Aft1/Aft2 transcription factors depends on mitochondrial but not cytosolic iron-sulfur protein biogenesis. Rutherford, J.C., Ojeda, L., Balk, J., Mühlenhoff, U., Lill, R., Winge, D.R. J. Biol. Chem. (2005) [Pubmed]
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