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Gene Review

Nubp2  -  nucleotide binding protein 2

Mus musculus

Synonyms: Cytosolic Fe-S cluster assembly factor NUBP2, D17Wsu11e, NBP 2, Nucleotide-binding protein 2
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Disease relevance of Nubp2

  • Interestingly, both regions are syntenic with human chromosome 16p13.1-p13.3, suggesting that a chromosomal breakage between Nubp2 and Nubp1 probably occurred during the evolution of mouse chromosomes [1].
  • The effect of dl-alpha-tocopheryl (vitamin E) succinate in combination with Prostaglandin A2 (PGA2) and sodium butyrate on mouse neuroblastoma cells (NBP2) in culture, according to the criteria of growth inhibition and morphological differentiation (neurite formation), was studied [2].
  • d- and dl-alpha-tocopheryl succinate inhibited growth and caused morphological changes in mouse melanoma (B-16), mouse neuroblastoma (NBP2), and rat glioma (C-6) cells in culture [3].
  • The presence of 1% ethanol in culture medium during heat treatment (40 degrees C for 8 hours and 43 degrees C for 15 minutes) was sufficient to enhance the effect of hyperthermia on murine neuroblastoma cells (NBP2) in culture, on the criteria of growth (number of viable cells per dish) and survival (colony formation) [4].

High impact information on Nubp2


Chemical compound and disease context of Nubp2


Biological context of Nubp2


Associations of Nubp2 with chemical compounds

  • The 1RB3AN27 cells were more effective in reducing the rate of methamphetamine-induced turning in rats with unilateral 6-OHDA lesion of the nigrostriatal system than differentiated NBP2 cells [11].
  • We then enriched for two populations of NBP2 cells; one expressing high levels of d2EGFP (HG) and the other expressing low levels of d2EGFP (LG) in the absence of doxycycline [13].
  • Their potency for growth inhibition in NBP2 clone reflected the order of: BrACh (ED50: 2 microM) greater than BETA (7.8 microM) congruent to BPTA congruent to (greater than 10 microM) congruent to TA-BETA congruent to OPTA [14].
  • Although elevation of intracellular levels of cyclic AMP in NBP2 clone invariably stimulates neurite formation and TH activity, these functions were increased in certain sera without a significant increase in the cellular cyclic AMP levels [15].


  1. Two novel mouse genes--Nubp2, mapped to the t-complex on chromosome 17, and Nubp1, mapped to chromosome 16--establish a new gene family of nucleotide-binding proteins in eukaryotes. Nakashima, H., Grahovac, M.J., Mazzarella, R., Fujiwara, H., Kitchen, J.R., Threat, T.A., Ko, M.S. Genomics (1999) [Pubmed]
  2. Effects of dl-alpha-tocopheryl succinate in combination with sodium butyrate and cAMP stimulating agent on neuroblastoma cells in culture. Rama, B.N., Prasad, K.N. Int. J. Cancer (1984) [Pubmed]
  3. Study on the specificity of alpha-tocopheryl (vitamin E) acid succinate effects on melanoma, glioma and neuroblastoma cells in culture. Rama, B.N., Prasad, K.N. Proc. Soc. Exp. Biol. Med. (1983) [Pubmed]
  4. Ethanol. A heat sensitizer on neuroblastoma cells in culture. Rama, B.N., Prasad, K.N. Cancer (1986) [Pubmed]
  5. Motor protein KIFC5A interacts with Nubp1 and Nubp2, and is implicated in the regulation of centrosome duplication. Christodoulou, A., Lederer, C.W., Surrey, T., Vernos, I., Santama, N. J. Cell. Sci. (2006) [Pubmed]
  6. Glucocorticoids increase tyrosine hydroxylase activity in cultured murine neuroblastoma. Williams, L.R., Sandquist, D., Black, A.C., Williams, T.H. J. Neurochem. (1981) [Pubmed]
  7. Regulated expression of VP16CREB in neuroblastoma cells: analysis of differentiation and apoptosis. Andreatta, C.P., Nahreini, P., Hanson, A.J., Prasad, K.N. J. Neurosci. Res. (2004) [Pubmed]
  8. Effect of methylmercuric chloride on gangliosides of mouse neuroblastoma cells in culture. Rebel, G., Guerin, P., Prasad, K.N. Lipids (1983) [Pubmed]
  9. Modification of the hyperthermic response on neuroblastoma cells by cAMP and sodium butyrate. Rama, B.N., Prasad, K.N. Cancer (1986) [Pubmed]
  10. New opportunities with neuronal cultures to study the mechanisms of neurotoxic injuries. Prasad, K.N. Neurotoxicology (1991) [Pubmed]
  11. Characterization and transplantation of two neuronal cell lines with dopaminergic properties. Adams, F.S., La Rosa, F.G., Kumar, S., Edwards-Prasad, J., Kentroti, S., Vernadakis, A., Freed, C.R., Prasad, K.N. Neurochem. Res. (1996) [Pubmed]
  12. dl-alpha-Tocopheryl succinate enhances the effect of gamma-irradiation on neuroblastoma cells in culture. Sarria, A., Prasad, K.N. Proc. Soc. Exp. Biol. Med. (1984) [Pubmed]
  13. Enrichment of cells exhibiting tetracycline regulated gene expression. Nahreini, P., Hanson, A.J., Prasad, K.N. BioTechniques (2003) [Pubmed]
  14. Effects of choline acetyltransferase inhibitors on the growth and differentiation of mouse neuroblastoma cells in culture. Chaturvedi, A.K., Prasad, K.N. Res. Commun. Chem. Pathol. Pharmacol. (1982) [Pubmed]
  15. Modification of response of mouse neuroblastoma cells in culture by serum type. Prasad, K.N., Spuhler, K., Arnold, E.B., Vernadakis, A. In vitro. (1979) [Pubmed]
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